4LZJ

Crystal Structure of MurQ from H.influenzae with bound inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006040	biological_process	amino sugar metabolic process
A	0009254	biological_process	peptidoglycan turnover
A	0016803	molecular_function	ether hydrolase activity
A	0016829	molecular_function	lyase activity
A	0016835	molecular_function	carbon-oxygen lyase activity
A	0046348	biological_process	amino sugar catabolic process
A	0097173	biological_process	N-acetylmuramic acid catabolic process
A	0097175	biological_process	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
A	0097367	molecular_function	carbohydrate derivative binding
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0006040	biological_process	amino sugar metabolic process
B	0009254	biological_process	peptidoglycan turnover
B	0016803	molecular_function	ether hydrolase activity
B	0016829	molecular_function	lyase activity
B	0016835	molecular_function	carbon-oxygen lyase activity
B	0046348	biological_process	amino sugar catabolic process
B	0097173	biological_process	N-acetylmuramic acid catabolic process
B	0097175	biological_process	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
B	0097367	molecular_function	carbohydrate derivative binding
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0006040	biological_process	amino sugar metabolic process
C	0009254	biological_process	peptidoglycan turnover
C	0016803	molecular_function	ether hydrolase activity
C	0016829	molecular_function	lyase activity
C	0016835	molecular_function	carbon-oxygen lyase activity
C	0046348	biological_process	amino sugar catabolic process
C	0097173	biological_process	N-acetylmuramic acid catabolic process
C	0097175	biological_process	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
C	0097367	molecular_function	carbohydrate derivative binding
C	1901135	biological_process	carbohydrate derivative metabolic process
D	0006040	biological_process	amino sugar metabolic process
D	0009254	biological_process	peptidoglycan turnover
D	0016803	molecular_function	ether hydrolase activity
D	0016829	molecular_function	lyase activity
D	0016835	molecular_function	carbon-oxygen lyase activity
D	0046348	biological_process	amino sugar catabolic process
D	0097173	biological_process	N-acetylmuramic acid catabolic process
D	0097175	biological_process	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
D	0097367	molecular_function	carbohydrate derivative binding
D	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE 22H B 401

Chain	Residue
B	GLY77
B	THR150
B	GLY197
B	SER199
B	ARG200
B	HOH524
B	HOH559
B	HOH584
B	HOH603
B	HOH615
C	GLU89
B	THR78
C	THR93
C	LYS239
C	LEU240
C	ARG243
C	HOH571
B	SER79
B	ARG81
B	PRO115
B	GLU120
B	ALA145
B	ALA146
B	SER147

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 401

Chain	Residue
B	LYS239
C	SER79
C	ALA145
C	ALA146
C	SER147
C	THR150
C	HOH515
C	HOH544

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 D 401

Chain	Residue
A	LYS239
D	ARG149
D	PRO151
D	HOH607

---

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE 22H D 402

Chain	Residue
A	GLU89
A	THR93
A	LYS239
A	LEU240
A	ARG243
A	HOH460
D	GLY77
D	THR78
D	SER79
D	ARG81
D	PRO115
D	GLU120
D	ALA145
D	ALA146
D	SER147
D	THR150
D	GLY197
D	SER199
D	ARG200
D	HOH521
D	HOH596
D	HOH597
D	HOH611
D	HOH621
D	HOH637

---

Functional Information from PROSITE/UniProt

site_id	PS01272
Number of Residues	18
Details	GCKR Glucokinase regulatory protein family signature. GPEiLTGSSRLKSGTaqK

Chain	Residue	Details
A	GLY191-LYS208

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	652
Details	Domain: {"description":"SIS"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---