Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4LZB

Uracil binding pocket in Vaccinia virus uracil DNA glycosylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0016787	molecular_function	hydrolase activity
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
B	0003677	molecular_function	DNA binding
B	0004844	molecular_function	uracil DNA N-glycosylase activity
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0016787	molecular_function	hydrolase activity
B	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
C	0003677	molecular_function	DNA binding
C	0004844	molecular_function	uracil DNA N-glycosylase activity
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0016787	molecular_function	hydrolase activity
C	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
D	0003677	molecular_function	DNA binding
D	0004844	molecular_function	uracil DNA N-glycosylase activity
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0016787	molecular_function	hydrolase activity
D	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
E	0003677	molecular_function	DNA binding
E	0004844	molecular_function	uracil DNA N-glycosylase activity
E	0006281	biological_process	DNA repair
E	0006974	biological_process	DNA damage response
E	0016787	molecular_function	hydrolase activity
E	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
F	0003677	molecular_function	DNA binding
F	0004844	molecular_function	uracil DNA N-glycosylase activity
F	0006281	biological_process	DNA repair
F	0006974	biological_process	DNA damage response
F	0016787	molecular_function	hydrolase activity
F	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
G	0003677	molecular_function	DNA binding
G	0004844	molecular_function	uracil DNA N-glycosylase activity
G	0006281	biological_process	DNA repair
G	0006974	biological_process	DNA damage response
G	0016787	molecular_function	hydrolase activity
G	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
H	0003677	molecular_function	DNA binding
H	0004844	molecular_function	uracil DNA N-glycosylase activity
H	0006281	biological_process	DNA repair
H	0006974	biological_process	DNA damage response
H	0016787	molecular_function	hydrolase activity
H	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
I	0003677	molecular_function	DNA binding
I	0004844	molecular_function	uracil DNA N-glycosylase activity
I	0006281	biological_process	DNA repair
I	0006974	biological_process	DNA damage response
I	0016787	molecular_function	hydrolase activity
I	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
J	0003677	molecular_function	DNA binding
J	0004844	molecular_function	uracil DNA N-glycosylase activity
J	0006281	biological_process	DNA repair
J	0006974	biological_process	DNA damage response
J	0016787	molecular_function	hydrolase activity
J	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
K	0003677	molecular_function	DNA binding
K	0004844	molecular_function	uracil DNA N-glycosylase activity
K	0006281	biological_process	DNA repair
K	0006974	biological_process	DNA damage response
K	0016787	molecular_function	hydrolase activity
K	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
L	0003677	molecular_function	DNA binding
L	0004844	molecular_function	uracil DNA N-glycosylase activity
L	0006281	biological_process	DNA repair
L	0006974	biological_process	DNA damage response
L	0016787	molecular_function	hydrolase activity
L	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 301

Chain	Residue
A	LEU38
A	ARG39
A	ASP40
A	GLU41
A	HOH616

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 302

Chain	Residue
A	HOH546
A	HOH631
A	ASP68
A	PRO69
A	URA308
A	HOH495

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 303

Chain	Residue
A	LYS160
A	TYR180
A	HIS181

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 304

Chain	Residue
A	TYR70
A	SER88

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	ILE103
A	TYR105

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	GLU190
A	HOH468
E	HOH456

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 307

Chain	Residue
A	ASP192
A	ARG193
A	HOH563
F	GLU203
F	ASN206
F	HOH575

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URA A 308

Chain	Residue
A	GLY66
A	ILE67
A	ASP68
A	TYR70
A	PRO78
A	PHE79
A	ASN120
A	HIS181
A	K302
A	HOH412

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS B 301

Chain	Residue
B	LYS160
B	ARG167
B	ILE177
B	VAL178
B	HOH430
E	THR175
E	LEU204

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 302

Chain	Residue
B	THR175
B	LEU204
E	ARG167
E	VAL178

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 303

Chain	Residue
B	ILE67
B	TYR121
B	ASP162
B	ILE166
B	LYS169
B	HOH468

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K B 304

Chain	Residue
B	THR149
B	VAL152
B	PRO173
B	EDO309
B	HOH420
F	HOH444

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K B 305

Chain	Residue
B	ASP68
B	PRO69
B	HOH596

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 306

Chain	Residue
B	ARG167
B	THR176
E	ARG167
E	THR176
E	HOH406

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 307

Chain	Residue
B	LYS160
B	TYR180
B	HIS181

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 308

Chain	Residue
B	ARG61
B	LYS207
B	ALA208
F	HOH476

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 309

Chain	Residue
B	SER153
B	PRO173
B	ASP205
B	K304
E	HOH574

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 310

Chain	Residue
B	ILE103
B	TYR105
B	HOH548

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 311

Chain	Residue
B	ARG98
B	LEU99

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE URA B 312

Chain	Residue
B	GLY66
B	ILE67
B	ASP68
B	TYR70
B	PRO78
B	PHE79
B	ASN120
B	HIS181
B	HOH402

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 301

Chain	Residue
C	ASP68
C	PRO69
C	THR130
C	HOH492
C	HOH493

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 302

Chain	Residue
C	LYS160
C	TYR180
C	HIS181

site_id	CC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URA C 303

Chain	Residue
C	GLY66
C	ILE67
C	ASP68
C	TYR70
C	PRO78
C	PHE79
C	ASN120
C	HIS181
C	HOH412
C	HOH493

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D 301

Chain	Residue
D	ASP68
D	PRO69
D	URA305
D	HOH495

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 302

Chain	Residue
D	LYS160
D	TYR180
D	HIS181

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 303

Chain	Residue
D	PHE84
D	TYR105
D	LYS106

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 304

Chain	Residue
D	THR149
D	LYS150
D	HIS151
D	VAL152
D	VAL174
G	ASP186

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URA D 305

Chain	Residue
D	GLY66
D	ILE67
D	ASP68
D	TYR70
D	PRO78
D	PHE79
D	ASN120
D	HIS181
D	K301
D	HOH408

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS E 301

Chain	Residue
E	GLY159
E	LYS160
E	THR161
E	ASP162

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K E 302

Chain	Residue
E	THR149
E	VAL152
E	PRO173
E	HOH567
E	HOH568

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 303

Chain	Residue
E	ASP68
E	PRO69
E	URA307
E	HOH571
E	HOH572
E	HOH573

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 304

Chain	Residue
E	LYS160
E	TYR180
E	HIS181

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 305

Chain	Residue
E	TYR70
E	SER88
E	HOH576

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO E 306

Chain	Residue
E	TYR105

site_id	DC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URA E 307

Chain	Residue
E	GLY66
E	ILE67
E	ASP68
E	TYR70
E	PRO78
E	PHE79
E	ASN120
E	HIS181
E	K303
E	HOH432
E	HOH571

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS F 301

Chain	Residue
F	ILE67
F	TYR121
F	ASP162
F	ASN165
F	LYS169

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K F 302

Chain	Residue
F	ASP68
F	PRO69
F	THR130
F	URA305
F	HOH584

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 303

Chain	Residue
F	GLY159
F	LYS160
F	HIS181
F	HOH450

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO F 304

Chain	Residue
F	ILE103
F	TYR105

site_id	EC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE URA F 305

Chain	Residue
F	GLY66
F	ILE67
F	ASP68
F	TYR70
F	PRO78
F	PHE79
F	ASN120
F	K302
F	HOH409

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 301

Chain	Residue
G	TYR70
G	SER88
G	HOH446

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS G 302

Chain	Residue
G	TYR121
G	TYR122
G	ASP162
G	HOH428

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K G 303

Chain	Residue
G	ASP68
G	PRO69
G	URA306
G	HOH539
G	HOH540

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO G 304

Chain	Residue
G	ILE103
G	TYR105

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 305

Chain	Residue
G	LYS160
G	TYR180
G	HIS181

site_id	FC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URA G 306

Chain	Residue
G	GLY66
G	ILE67
G	ASP68
G	TYR70
G	PRO78
G	PHE79
G	ASN120
G	HIS181
G	K303
G	HOH405
G	HOH540

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO G 307

Chain	Residue
G	GLU32
G	SER35
G	TRP36

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 301

Chain	Residue
H	LYS160
H	TYR180
H	HIS181

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS H 302

Chain	Residue
D	ILE197
H	THR175
H	LEU201
H	ASP205

site_id	FC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS H 303

Chain	Residue
H	TYR121
H	TYR122
H	ASP162
H	ASN165
H	ILE166
H	LYS169

site_id	FC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE URA H 304

Chain	Residue
H	GLY66
H	ILE67
H	ASP68
H	TYR70
H	PRO78
H	PHE79
H	ASN120
H	HIS181

site_id	FC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO I 301

Chain	Residue
I	ILE103
I	TYR105

site_id	FC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO I 302

Chain	Residue
I	TYR121
I	TYR122
I	ASP162
I	PHE163
I	ILE166

site_id	FC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE URA I 303

Chain	Residue
I	GLY66
I	ILE67
I	ASP68
I	TYR70
I	PRO78
I	PHE79
I	ASN120
I	HIS181
I	HOH410

site_id	GC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URA J 301

Chain	Residue
J	GLY66
J	ILE67
J	ASP68
J	TYR70
J	PRO78
J	PHE79
J	ASN120
J	HIS181
J	K303
J	HOH415

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS J 302

Chain	Residue
J	TYR121
J	ASP162
J	ASN165
J	LYS169

site_id	GC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K J 303

Chain	Residue
J	ASP68
J	PRO69
J	THR130
J	URA301
J	HOH505
J	HOH506
J	HOH507

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL K 301

Chain	Residue
K	LYS160
K	TYR180
K	HIS181
K	ALA184

site_id	GC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO K 302

Chain	Residue
K	ASP162
K	ILE166
K	LYS169

site_id	GC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URA K 303

Chain	Residue
K	GLY66
K	ILE67
K	ASP68
K	TYR70
K	PRO78
K	PHE79
K	ASN120
K	HIS181
K	HOH424
K	HOH460

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO L 301

Chain	Residue
L	TYR121
L	TYR122
L	ASP162
L	LYS169

site_id	GC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URA L 302

Chain	Residue
L	GLY66
L	ILE67
L	ASP68
L	TYR70
L	PRO78
L	PHE79
L	ASN120
L	HIS181
L	HOH416
L	HOH418

Functional Information from PROSITE/UniProt

site_id	PS00130
Number of Residues	10
Details	U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVCVcGIDPY

Chain	Residue	Details
A	ARG61-TYR70

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10072","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)