4LZB
Uracil binding pocket in Vaccinia virus uracil DNA glycosylase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
A | 0006281 | biological_process | DNA repair |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
B | 0003677 | molecular_function | DNA binding |
B | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
B | 0006281 | biological_process | DNA repair |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
C | 0003677 | molecular_function | DNA binding |
C | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
C | 0006281 | biological_process | DNA repair |
C | 0016787 | molecular_function | hydrolase activity |
C | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
D | 0003677 | molecular_function | DNA binding |
D | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
D | 0006281 | biological_process | DNA repair |
D | 0016787 | molecular_function | hydrolase activity |
D | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
E | 0003677 | molecular_function | DNA binding |
E | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
E | 0006281 | biological_process | DNA repair |
E | 0016787 | molecular_function | hydrolase activity |
E | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
F | 0003677 | molecular_function | DNA binding |
F | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
F | 0006281 | biological_process | DNA repair |
F | 0016787 | molecular_function | hydrolase activity |
F | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
G | 0003677 | molecular_function | DNA binding |
G | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
G | 0006281 | biological_process | DNA repair |
G | 0016787 | molecular_function | hydrolase activity |
G | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
H | 0003677 | molecular_function | DNA binding |
H | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
H | 0006281 | biological_process | DNA repair |
H | 0016787 | molecular_function | hydrolase activity |
H | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
I | 0003677 | molecular_function | DNA binding |
I | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
I | 0006281 | biological_process | DNA repair |
I | 0016787 | molecular_function | hydrolase activity |
I | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
J | 0003677 | molecular_function | DNA binding |
J | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
J | 0006281 | biological_process | DNA repair |
J | 0016787 | molecular_function | hydrolase activity |
J | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
K | 0003677 | molecular_function | DNA binding |
K | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
K | 0006281 | biological_process | DNA repair |
K | 0016787 | molecular_function | hydrolase activity |
K | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
L | 0003677 | molecular_function | DNA binding |
L | 0004844 | molecular_function | uracil DNA N-glycosylase activity |
L | 0006281 | biological_process | DNA repair |
L | 0016787 | molecular_function | hydrolase activity |
L | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 301 |
Chain | Residue |
A | LEU38 |
A | ARG39 |
A | ASP40 |
A | GLU41 |
A | HOH616 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 302 |
Chain | Residue |
A | HOH546 |
A | HOH631 |
A | ASP68 |
A | PRO69 |
A | URA308 |
A | HOH495 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 303 |
Chain | Residue |
A | LYS160 |
A | TYR180 |
A | HIS181 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 304 |
Chain | Residue |
A | TYR70 |
A | SER88 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 305 |
Chain | Residue |
A | ILE103 |
A | TYR105 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 306 |
Chain | Residue |
A | GLU190 |
A | HOH468 |
E | HOH456 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 307 |
Chain | Residue |
A | ASP192 |
A | ARG193 |
A | HOH563 |
F | GLU203 |
F | ASN206 |
F | HOH575 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE URA A 308 |
Chain | Residue |
A | GLY66 |
A | ILE67 |
A | ASP68 |
A | TYR70 |
A | PRO78 |
A | PHE79 |
A | ASN120 |
A | HIS181 |
A | K302 |
A | HOH412 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS B 301 |
Chain | Residue |
B | LYS160 |
B | ARG167 |
B | ILE177 |
B | VAL178 |
B | HOH430 |
E | THR175 |
E | LEU204 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 302 |
Chain | Residue |
B | THR175 |
B | LEU204 |
E | ARG167 |
E | VAL178 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS B 303 |
Chain | Residue |
B | ILE67 |
B | TYR121 |
B | ASP162 |
B | ILE166 |
B | LYS169 |
B | HOH468 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K B 304 |
Chain | Residue |
B | THR149 |
B | VAL152 |
B | PRO173 |
B | EDO309 |
B | HOH420 |
F | HOH444 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K B 305 |
Chain | Residue |
B | ASP68 |
B | PRO69 |
B | HOH596 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL B 306 |
Chain | Residue |
B | ARG167 |
B | THR176 |
E | ARG167 |
E | THR176 |
E | HOH406 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 307 |
Chain | Residue |
B | LYS160 |
B | TYR180 |
B | HIS181 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 308 |
Chain | Residue |
B | ARG61 |
B | LYS207 |
B | ALA208 |
F | HOH476 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 309 |
Chain | Residue |
B | SER153 |
B | PRO173 |
B | ASP205 |
B | K304 |
E | HOH574 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B 310 |
Chain | Residue |
B | ILE103 |
B | TYR105 |
B | HOH548 |
site_id | CC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 311 |
Chain | Residue |
B | ARG98 |
B | LEU99 |
site_id | CC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE URA B 312 |
Chain | Residue |
B | GLY66 |
B | ILE67 |
B | ASP68 |
B | TYR70 |
B | PRO78 |
B | PHE79 |
B | ASN120 |
B | HIS181 |
B | HOH402 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 301 |
Chain | Residue |
C | ASP68 |
C | PRO69 |
C | THR130 |
C | HOH492 |
C | HOH493 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 302 |
Chain | Residue |
C | LYS160 |
C | TYR180 |
C | HIS181 |
site_id | CC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE URA C 303 |
Chain | Residue |
C | GLY66 |
C | ILE67 |
C | ASP68 |
C | TYR70 |
C | PRO78 |
C | PHE79 |
C | ASN120 |
C | HIS181 |
C | HOH412 |
C | HOH493 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K D 301 |
Chain | Residue |
D | ASP68 |
D | PRO69 |
D | URA305 |
D | HOH495 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL D 302 |
Chain | Residue |
D | LYS160 |
D | TYR180 |
D | HIS181 |
site_id | CC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO D 303 |
Chain | Residue |
D | PHE84 |
D | TYR105 |
D | LYS106 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO D 304 |
Chain | Residue |
D | THR149 |
D | LYS150 |
D | HIS151 |
D | VAL152 |
D | VAL174 |
G | ASP186 |
site_id | DC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE URA D 305 |
Chain | Residue |
D | GLY66 |
D | ILE67 |
D | ASP68 |
D | TYR70 |
D | PRO78 |
D | PHE79 |
D | ASN120 |
D | HIS181 |
D | K301 |
D | HOH408 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS E 301 |
Chain | Residue |
E | GLY159 |
E | LYS160 |
E | THR161 |
E | ASP162 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K E 302 |
Chain | Residue |
E | THR149 |
E | VAL152 |
E | PRO173 |
E | HOH567 |
E | HOH568 |
site_id | DC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K E 303 |
Chain | Residue |
E | ASP68 |
E | PRO69 |
E | URA307 |
E | HOH571 |
E | HOH572 |
E | HOH573 |
site_id | DC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL E 304 |
Chain | Residue |
E | LYS160 |
E | TYR180 |
E | HIS181 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL E 305 |
Chain | Residue |
E | TYR70 |
E | SER88 |
E | HOH576 |
site_id | DC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO E 306 |
Chain | Residue |
E | TYR105 |
site_id | DC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE URA E 307 |
Chain | Residue |
E | GLY66 |
E | ILE67 |
E | ASP68 |
E | TYR70 |
E | PRO78 |
E | PHE79 |
E | ASN120 |
E | HIS181 |
E | K303 |
E | HOH432 |
E | HOH571 |
site_id | DC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS F 301 |
Chain | Residue |
F | ILE67 |
F | TYR121 |
F | ASP162 |
F | ASN165 |
F | LYS169 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K F 302 |
Chain | Residue |
F | ASP68 |
F | PRO69 |
F | THR130 |
F | URA305 |
F | HOH584 |
site_id | EC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL F 303 |
Chain | Residue |
F | GLY159 |
F | LYS160 |
F | HIS181 |
F | HOH450 |
site_id | EC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO F 304 |
Chain | Residue |
F | ILE103 |
F | TYR105 |
site_id | EC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE URA F 305 |
Chain | Residue |
F | GLY66 |
F | ILE67 |
F | ASP68 |
F | TYR70 |
F | PRO78 |
F | PHE79 |
F | ASN120 |
F | K302 |
F | HOH409 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL G 301 |
Chain | Residue |
G | TYR70 |
G | SER88 |
G | HOH446 |
site_id | EC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS G 302 |
Chain | Residue |
G | TYR121 |
G | TYR122 |
G | ASP162 |
G | HOH428 |
site_id | EC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K G 303 |
Chain | Residue |
G | ASP68 |
G | PRO69 |
G | URA306 |
G | HOH539 |
G | HOH540 |
site_id | EC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO G 304 |
Chain | Residue |
G | ILE103 |
G | TYR105 |
site_id | EC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL G 305 |
Chain | Residue |
G | LYS160 |
G | TYR180 |
G | HIS181 |
site_id | FC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE URA G 306 |
Chain | Residue |
G | GLY66 |
G | ILE67 |
G | ASP68 |
G | TYR70 |
G | PRO78 |
G | PHE79 |
G | ASN120 |
G | HIS181 |
G | K303 |
G | HOH405 |
G | HOH540 |
site_id | FC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO G 307 |
Chain | Residue |
G | GLU32 |
G | SER35 |
G | TRP36 |
site_id | FC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL H 301 |
Chain | Residue |
H | LYS160 |
H | TYR180 |
H | HIS181 |
site_id | FC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS H 302 |
Chain | Residue |
D | ILE197 |
H | THR175 |
H | LEU201 |
H | ASP205 |
site_id | FC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS H 303 |
Chain | Residue |
H | TYR121 |
H | TYR122 |
H | ASP162 |
H | ASN165 |
H | ILE166 |
H | LYS169 |
site_id | FC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE URA H 304 |
Chain | Residue |
H | GLY66 |
H | ILE67 |
H | ASP68 |
H | TYR70 |
H | PRO78 |
H | PHE79 |
H | ASN120 |
H | HIS181 |
site_id | FC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO I 301 |
Chain | Residue |
I | ILE103 |
I | TYR105 |
site_id | FC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO I 302 |
Chain | Residue |
I | TYR121 |
I | TYR122 |
I | ASP162 |
I | PHE163 |
I | ILE166 |
site_id | FC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE URA I 303 |
Chain | Residue |
I | GLY66 |
I | ILE67 |
I | ASP68 |
I | TYR70 |
I | PRO78 |
I | PHE79 |
I | ASN120 |
I | HIS181 |
I | HOH410 |
site_id | GC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE URA J 301 |
Chain | Residue |
J | GLY66 |
J | ILE67 |
J | ASP68 |
J | TYR70 |
J | PRO78 |
J | PHE79 |
J | ASN120 |
J | HIS181 |
J | K303 |
J | HOH415 |
site_id | GC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS J 302 |
Chain | Residue |
J | TYR121 |
J | ASP162 |
J | ASN165 |
J | LYS169 |
site_id | GC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K J 303 |
Chain | Residue |
J | ASP68 |
J | PRO69 |
J | THR130 |
J | URA301 |
J | HOH505 |
J | HOH506 |
J | HOH507 |
site_id | GC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL K 301 |
Chain | Residue |
K | LYS160 |
K | TYR180 |
K | HIS181 |
K | ALA184 |
site_id | GC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO K 302 |
Chain | Residue |
K | ASP162 |
K | ILE166 |
K | LYS169 |
site_id | GC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE URA K 303 |
Chain | Residue |
K | GLY66 |
K | ILE67 |
K | ASP68 |
K | TYR70 |
K | PRO78 |
K | PHE79 |
K | ASN120 |
K | HIS181 |
K | HOH424 |
K | HOH460 |
site_id | GC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO L 301 |
Chain | Residue |
L | TYR121 |
L | TYR122 |
L | ASP162 |
L | LYS169 |
site_id | GC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE URA L 302 |
Chain | Residue |
L | GLY66 |
L | ILE67 |
L | ASP68 |
L | TYR70 |
L | PRO78 |
L | PHE79 |
L | ASN120 |
L | HIS181 |
L | HOH416 |
L | HOH418 |
Functional Information from PROSITE/UniProt
site_id | PS00130 |
Number of Residues | 10 |
Details | U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVCVcGIDPY |
Chain | Residue | Details |
A | ARG61-TYR70 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10072 |
Chain | Residue | Details |
A | ASP68 | |
J | ASP68 | |
K | ASP68 | |
L | ASP68 | |
B | ASP68 | |
C | ASP68 | |
D | ASP68 | |
E | ASP68 | |
F | ASP68 | |
G | ASP68 | |
H | ASP68 | |
I | ASP68 |