4LXJ

Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006696	biological_process	ergosterol biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008398	molecular_function	sterol 14-demethylase activity
A	0016020	cellular_component	membrane
A	0016126	biological_process	sterol biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM A 601

Chain	Residue
A	PHE113
A	THR322
A	LEU374
A	PRO379
A	LEU383
A	ARG385
A	PRO462
A	PHE463
A	GLY464
A	HIS468
A	CYS470
A	TYR126
A	GLY472
A	ALA476
A	LAN602
A	OXY603
A	HOH708
A	TYR140
A	LEU147
A	LYS151
A	VAL311
A	GLY314
A	GLY315
A	THR318

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE LAN A 602

Chain	Residue
A	TYR126
A	LEU129
A	THR130
A	TYR140
A	PHE236
A	PHE241
A	GLY310
A	GLY314
A	LEU380
A	HIS381
A	SER382
A	LEU383
A	PHE384
A	PHE506
A	THR507
A	SER508
A	MET509
A	HEM601

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OXY A 603

Chain	Residue
A	GLY314
A	HEM601

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Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG

Chain	Residue	Details
A	PHE463-GLY472

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"16847258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24613931","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	488
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"16847258","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24613931","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24613931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LXJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24613931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"24613931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LXJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5EQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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