4LW2
Structural changes during cysteine desulfurase CsdA and sulfur-acceptor CsdE interactions provide insight into the trans-persulfuration
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| A | 0009000 | molecular_function | selenocysteine lyase activity |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0016261 | biological_process | L-selenocysteine catabolic process |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0019448 | biological_process | L-cysteine catabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031071 | molecular_function | cysteine desulfurase activity |
| A | 0072348 | biological_process | sulfur compound transport |
| A | 1990221 | cellular_component | L-cysteine desulfurase complex |
| B | 0000096 | biological_process | sulfur amino acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| B | 0009000 | molecular_function | selenocysteine lyase activity |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016261 | biological_process | L-selenocysteine catabolic process |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0019448 | biological_process | L-cysteine catabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031071 | molecular_function | cysteine desulfurase activity |
| B | 0072348 | biological_process | sulfur compound transport |
| B | 1990221 | cellular_component | L-cysteine desulfurase complex |
| C | 0000096 | biological_process | sulfur amino acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| C | 0009000 | molecular_function | selenocysteine lyase activity |
| C | 0016226 | biological_process | iron-sulfur cluster assembly |
| C | 0016261 | biological_process | L-selenocysteine catabolic process |
| C | 0016783 | molecular_function | sulfurtransferase activity |
| C | 0019448 | biological_process | L-cysteine catabolic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0031071 | molecular_function | cysteine desulfurase activity |
| C | 0072348 | biological_process | sulfur compound transport |
| C | 1990221 | cellular_component | L-cysteine desulfurase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PLP A 501 |
| Chain | Residue |
| A | THR90 |
| A | LYS222 |
| A | THR273 |
| A | HOH661 |
| A | HOH702 |
| A | THR91 |
| A | HIS119 |
| A | ASN171 |
| A | ASP196 |
| A | ALA198 |
| A | GLN199 |
| A | SER219 |
| A | HIS221 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | ALA26 |
| A | ALA27 |
| A | ASN171 |
| A | ARG353 |
| A | HIS357 |
| A | ARG373 |
| A | HOH688 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP B 501 |
| Chain | Residue |
| B | THR90 |
| B | THR91 |
| B | HIS119 |
| B | ASN171 |
| B | ASP196 |
| B | ALA198 |
| B | GLN199 |
| B | SER219 |
| B | HIS221 |
| B | LYS222 |
| B | HOH616 |
| B | HOH662 |
| C | THR273 |
| C | HOH626 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 502 |
| Chain | Residue |
| B | ALA26 |
| B | ALA27 |
| B | ASN171 |
| B | LYS222 |
| B | ARG353 |
| B | HIS357 |
| B | ARG373 |
| B | HOH640 |
| B | HOH692 |
| B | HOH913 |
| B | HOH956 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP C 501 |
| Chain | Residue |
| B | GLY272 |
| B | THR273 |
| C | THR90 |
| C | THR91 |
| C | HIS119 |
| C | ASN171 |
| C | ASP196 |
| C | ALA198 |
| C | GLN199 |
| C | SER219 |
| C | HIS221 |
| C | LYS222 |
| C | HOH618 |
| C | HOH764 |
| C | HOH890 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 502 |
| Chain | Residue |
| C | ALA26 |
| C | ALA27 |
| C | ASN171 |
| C | ARG353 |
| C | HIS357 |
| C | ARG373 |
| C | HOH669 |
| C | HOH700 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDFYafSGHKlygpt.GiGvL |
| Chain | Residue | Details |
| A | ILE213-LEU232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"10739946","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
