4LV7
Crystal structure of inositol 1,3,4,5,6-pentakisphosphate 2-kinase E82C/S142C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0010264 | biological_process | myo-inositol hexakisphosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| A | 0032942 | molecular_function | inositol-1,4,5,6-tetrakisphosphate 2-kinase activity |
| A | 0032958 | biological_process | inositol phosphate biosynthetic process |
| A | 0035299 | molecular_function | inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048527 | biological_process | lateral root development |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0051607 | biological_process | defense response to virus |
| A | 0055062 | biological_process | phosphate ion homeostasis |
| A | 0102731 | molecular_function | inositol-1,3,4,6-tetrakisphosphate 2-kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0010264 | biological_process | myo-inositol hexakisphosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| B | 0032942 | molecular_function | inositol-1,4,5,6-tetrakisphosphate 2-kinase activity |
| B | 0032958 | biological_process | inositol phosphate biosynthetic process |
| B | 0035299 | molecular_function | inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048527 | biological_process | lateral root development |
| B | 0050832 | biological_process | defense response to fungus |
| B | 0051607 | biological_process | defense response to virus |
| B | 0055062 | biological_process | phosphate ion homeostasis |
| B | 0102731 | molecular_function | inositol-1,3,4,6-tetrakisphosphate 2-kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE IHP A 501 |
| Chain | Residue |
| A | GLY19 |
| A | ASN238 |
| A | ASP368 |
| A | ASP407 |
| A | LYS411 |
| A | ARG415 |
| A | TYR419 |
| A | ADP502 |
| A | MG503 |
| A | GLY20 |
| A | ALA21 |
| A | ARG45 |
| A | ARG130 |
| A | LYS168 |
| A | LYS170 |
| A | HIS196 |
| A | LYS200 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP A 502 |
| Chain | Residue |
| A | GLY17 |
| A | GLY19 |
| A | GLY20 |
| A | ALA21 |
| A | ASN22 |
| A | VAL24 |
| A | VAL38 |
| A | ARG40 |
| A | ASN147 |
| A | ASP148 |
| A | HIS149 |
| A | GLU166 |
| A | ARG241 |
| A | PHE243 |
| A | MET372 |
| A | ILE406 |
| A | ASP407 |
| A | IHP501 |
| A | MG503 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 503 |
| Chain | Residue |
| A | ARG40 |
| A | ASP407 |
| A | SER409 |
| A | IHP501 |
| A | ADP502 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 504 |
| Chain | Residue |
| A | HIS320 |
| A | CYS330 |
| A | CYS333 |
| A | HIS346 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE IHP B 501 |
| Chain | Residue |
| B | GLY19 |
| B | GLY20 |
| B | ALA21 |
| B | ARG130 |
| B | LYS168 |
| B | LYS170 |
| B | HIS196 |
| B | LYS200 |
| B | ASN238 |
| B | ASP368 |
| B | ASP407 |
| B | LYS411 |
| B | ARG415 |
| B | TYR419 |
| B | ADP502 |
| B | MG503 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP B 502 |
| Chain | Residue |
| B | ARG16 |
| B | GLY17 |
| B | GLU18 |
| B | GLY19 |
| B | GLY20 |
| B | ALA21 |
| B | ASN22 |
| B | VAL24 |
| B | ARG40 |
| B | ASN147 |
| B | ASP148 |
| B | HIS149 |
| B | GLU166 |
| B | ARG241 |
| B | ASP407 |
| B | IHP501 |
| B | MG503 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 503 |
| Chain | Residue |
| B | GLY19 |
| B | ASP407 |
| B | IHP501 |
| B | ADP502 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 504 |
| Chain | Residue |
| B | HIS320 |
| B | CYS330 |
| B | CYS333 |
| B | HIS346 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"EXKPK motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20453199","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20453199","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362712","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22684075","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22745128","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2XAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2XAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AQK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AXF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
