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4LOP

Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0000165biological_processMAPK cascade
A0000902biological_processcell morphogenesis
A0000922cellular_componentspindle pole
A0001502biological_processcartilage condensation
A0001525biological_processangiogenesis
A0001649biological_processosteoblast differentiation
A0001890biological_processplacenta development
A0002021biological_processresponse to dietary excess
A0002062biological_processchondrocyte differentiation
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004707molecular_functionMAP kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006366biological_processtranscription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
A0007519biological_processskeletal muscle tissue development
A0010628biological_processpositive regulation of gene expression
A0010831biological_processpositive regulation of myotube differentiation
A0016301molecular_functionkinase activity
A0016607cellular_componentnuclear speck
A0018105biological_processpeptidyl-serine phosphorylation
A0019395biological_processfatty acid oxidation
A0019899molecular_functionenzyme binding
A0019903molecular_functionprotein phosphatase binding
A0030278biological_processregulation of ossification
A0030316biological_processosteoclast differentiation
A0031098biological_processstress-activated protein kinase signaling cascade
A0031663biological_processlipopolysaccharide-mediated signaling pathway
A0032495biological_processresponse to muramyl dipeptide
A0032496biological_processresponse to lipopolysaccharide
A0032735biological_processpositive regulation of interleukin-12 production
A0032868biological_processresponse to insulin
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0035994biological_processresponse to muscle stretch
A0038066biological_processp38MAPK cascade
A0042307biological_processpositive regulation of protein import into nucleus
A0042770biological_processsignal transduction in response to DNA damage
A0043229cellular_componentintracellular organelle
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045663biological_processpositive regulation of myoblast differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046323biological_processglucose import
A0046326biological_processpositive regulation of glucose import
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048273molecular_functionmitogen-activated protein kinase p38 binding
A0048863biological_processstem cell differentiation
A0051146biological_processstriated muscle cell differentiation
A0051403biological_processstress-activated MAPK cascade
A0051525molecular_functionNFAT protein binding
A0060045biological_processpositive regulation of cardiac muscle cell proliferation
A0060348biological_processbone development
A0071222biological_processcellular response to lipopolysaccharide
A0071223biological_processcellular response to lipoteichoic acid
A0071356biological_processcellular response to tumor necrosis factor
A0071479biological_processcellular response to ionizing radiation
A0071493biological_processcellular response to UV-B
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090336biological_processpositive regulation of brown fat cell differentiation
A0090400biological_processstress-induced premature senescence
A0098586biological_processcellular response to virus
A0098978cellular_componentglutamatergic synapse
A0099179biological_processregulation of synaptic membrane adhesion
A0106310molecular_functionprotein serine kinase activity
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1901741biological_processpositive regulation of myoblast fusion
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0000077biological_processDNA damage checkpoint signaling
B0000165biological_processMAPK cascade
B0000902biological_processcell morphogenesis
B0000922cellular_componentspindle pole
B0001502biological_processcartilage condensation
B0001525biological_processangiogenesis
B0001649biological_processosteoblast differentiation
B0001890biological_processplacenta development
B0002021biological_processresponse to dietary excess
B0002062biological_processchondrocyte differentiation
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006366biological_processtranscription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
B0007519biological_processskeletal muscle tissue development
B0010628biological_processpositive regulation of gene expression
B0010831biological_processpositive regulation of myotube differentiation
B0016301molecular_functionkinase activity
B0016607cellular_componentnuclear speck
B0018105biological_processpeptidyl-serine phosphorylation
B0019395biological_processfatty acid oxidation
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0030278biological_processregulation of ossification
B0030316biological_processosteoclast differentiation
B0031098biological_processstress-activated protein kinase signaling cascade
B0031663biological_processlipopolysaccharide-mediated signaling pathway
B0032495biological_processresponse to muramyl dipeptide
B0032496biological_processresponse to lipopolysaccharide
B0032735biological_processpositive regulation of interleukin-12 production
B0032868biological_processresponse to insulin
B0035331biological_processnegative regulation of hippo signaling
B0035556biological_processintracellular signal transduction
B0035924biological_processcellular response to vascular endothelial growth factor stimulus
B0035994biological_processresponse to muscle stretch
B0038066biological_processp38MAPK cascade
B0042307biological_processpositive regulation of protein import into nucleus
B0042770biological_processsignal transduction in response to DNA damage
B0043229cellular_componentintracellular organelle
B0045648biological_processpositive regulation of erythrocyte differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046323biological_processglucose import
B0046326biological_processpositive regulation of glucose import
B0048010biological_processvascular endothelial growth factor receptor signaling pathway
B0048273molecular_functionmitogen-activated protein kinase p38 binding
B0048863biological_processstem cell differentiation
B0051146biological_processstriated muscle cell differentiation
B0051403biological_processstress-activated MAPK cascade
B0051525molecular_functionNFAT protein binding
B0060045biological_processpositive regulation of cardiac muscle cell proliferation
B0060348biological_processbone development
B0071222biological_processcellular response to lipopolysaccharide
B0071223biological_processcellular response to lipoteichoic acid
B0071356biological_processcellular response to tumor necrosis factor
B0071479biological_processcellular response to ionizing radiation
B0071493biological_processcellular response to UV-B
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090336biological_processpositive regulation of brown fat cell differentiation
B0090400biological_processstress-induced premature senescence
B0098586biological_processcellular response to virus
B0098978cellular_componentglutamatergic synapse
B0099179biological_processregulation of synaptic membrane adhesion
B0106310molecular_functionprotein serine kinase activity
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1901741biological_processpositive regulation of myoblast fusion
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0000077biological_processDNA damage checkpoint signaling
C0000165biological_processMAPK cascade
C0000902biological_processcell morphogenesis
C0000922cellular_componentspindle pole
C0001502biological_processcartilage condensation
C0001525biological_processangiogenesis
C0001649biological_processosteoblast differentiation
C0001890biological_processplacenta development
C0002021biological_processresponse to dietary excess
C0002062biological_processchondrocyte differentiation
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004707molecular_functionMAP kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006006biological_processglucose metabolic process
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006366biological_processtranscription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
C0007519biological_processskeletal muscle tissue development
C0010628biological_processpositive regulation of gene expression
C0010831biological_processpositive regulation of myotube differentiation
C0016301molecular_functionkinase activity
C0016607cellular_componentnuclear speck
C0018105biological_processpeptidyl-serine phosphorylation
C0019395biological_processfatty acid oxidation
C0019899molecular_functionenzyme binding
C0019903molecular_functionprotein phosphatase binding
C0030278biological_processregulation of ossification
C0030316biological_processosteoclast differentiation
C0031098biological_processstress-activated protein kinase signaling cascade
C0031663biological_processlipopolysaccharide-mediated signaling pathway
C0032495biological_processresponse to muramyl dipeptide
C0032496biological_processresponse to lipopolysaccharide
C0032735biological_processpositive regulation of interleukin-12 production
C0032868biological_processresponse to insulin
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035924biological_processcellular response to vascular endothelial growth factor stimulus
C0035994biological_processresponse to muscle stretch
C0038066biological_processp38MAPK cascade
C0042307biological_processpositive regulation of protein import into nucleus
C0042770biological_processsignal transduction in response to DNA damage
C0043229cellular_componentintracellular organelle
C0045648biological_processpositive regulation of erythrocyte differentiation
C0045663biological_processpositive regulation of myoblast differentiation
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046323biological_processglucose import
C0046326biological_processpositive regulation of glucose import
C0048010biological_processvascular endothelial growth factor receptor signaling pathway
C0048273molecular_functionmitogen-activated protein kinase p38 binding
C0048863biological_processstem cell differentiation
C0051146biological_processstriated muscle cell differentiation
C0051403biological_processstress-activated MAPK cascade
C0051525molecular_functionNFAT protein binding
C0060045biological_processpositive regulation of cardiac muscle cell proliferation
C0060348biological_processbone development
C0071222biological_processcellular response to lipopolysaccharide
C0071223biological_processcellular response to lipoteichoic acid
C0071356biological_processcellular response to tumor necrosis factor
C0071479biological_processcellular response to ionizing radiation
C0071493biological_processcellular response to UV-B
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090336biological_processpositive regulation of brown fat cell differentiation
C0090400biological_processstress-induced premature senescence
C0098586biological_processcellular response to virus
C0098978cellular_componentglutamatergic synapse
C0099179biological_processregulation of synaptic membrane adhesion
C0106310molecular_functionprotein serine kinase activity
C1900015biological_processregulation of cytokine production involved in inflammatory response
C1901741biological_processpositive regulation of myoblast fusion
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0000077biological_processDNA damage checkpoint signaling
D0000165biological_processMAPK cascade
D0000902biological_processcell morphogenesis
D0000922cellular_componentspindle pole
D0001502biological_processcartilage condensation
D0001525biological_processangiogenesis
D0001649biological_processosteoblast differentiation
D0001890biological_processplacenta development
D0002021biological_processresponse to dietary excess
D0002062biological_processchondrocyte differentiation
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004707molecular_functionMAP kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006006biological_processglucose metabolic process
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0006366biological_processtranscription by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0006915biological_processapoptotic process
D0006974biological_processDNA damage response
D0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
D0007519biological_processskeletal muscle tissue development
D0010628biological_processpositive regulation of gene expression
D0010831biological_processpositive regulation of myotube differentiation
D0016301molecular_functionkinase activity
D0016607cellular_componentnuclear speck
D0018105biological_processpeptidyl-serine phosphorylation
D0019395biological_processfatty acid oxidation
D0019899molecular_functionenzyme binding
D0019903molecular_functionprotein phosphatase binding
D0030278biological_processregulation of ossification
D0030316biological_processosteoclast differentiation
D0031098biological_processstress-activated protein kinase signaling cascade
D0031663biological_processlipopolysaccharide-mediated signaling pathway
D0032495biological_processresponse to muramyl dipeptide
D0032496biological_processresponse to lipopolysaccharide
D0032735biological_processpositive regulation of interleukin-12 production
D0032868biological_processresponse to insulin
D0035331biological_processnegative regulation of hippo signaling
D0035556biological_processintracellular signal transduction
D0035924biological_processcellular response to vascular endothelial growth factor stimulus
D0035994biological_processresponse to muscle stretch
D0038066biological_processp38MAPK cascade
D0042307biological_processpositive regulation of protein import into nucleus
D0042770biological_processsignal transduction in response to DNA damage
D0043229cellular_componentintracellular organelle
D0045648biological_processpositive regulation of erythrocyte differentiation
D0045663biological_processpositive regulation of myoblast differentiation
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046323biological_processglucose import
D0046326biological_processpositive regulation of glucose import
D0048010biological_processvascular endothelial growth factor receptor signaling pathway
D0048273molecular_functionmitogen-activated protein kinase p38 binding
D0048863biological_processstem cell differentiation
D0051146biological_processstriated muscle cell differentiation
D0051403biological_processstress-activated MAPK cascade
D0051525molecular_functionNFAT protein binding
D0060045biological_processpositive regulation of cardiac muscle cell proliferation
D0060348biological_processbone development
D0071222biological_processcellular response to lipopolysaccharide
D0071223biological_processcellular response to lipoteichoic acid
D0071356biological_processcellular response to tumor necrosis factor
D0071479biological_processcellular response to ionizing radiation
D0071493biological_processcellular response to UV-B
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090336biological_processpositive regulation of brown fat cell differentiation
D0090400biological_processstress-induced premature senescence
D0098586biological_processcellular response to virus
D0098978cellular_componentglutamatergic synapse
D0099179biological_processregulation of synaptic membrane adhesion
D0106310molecular_functionprotein serine kinase activity
D1900015biological_processregulation of cytokine production involved in inflammatory response
D1901741biological_processpositive regulation of myoblast fusion
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE SB4 A 401
ChainResidue
ASER32
AASP112
ALEU167
AHOH670
AHOH721
AVAL38
AALA51
ALEU104
AVAL105
ATHR106
AHIS107
ALEU108
AMET109

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE TLA A 402
ChainResidue
AARG149
AARG173
AHIS174
ATRP197
ATYR200
AEDO405
AHOH597
AHOH703
DARG330
DASP331

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 403
ChainResidue
ALYS118
ATRP187
ATHR221
AHOH547
CARG10

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 404
ChainResidue
ATHR46
AGLY47
AHIS48
AGLU253
ASER254

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 405
ChainResidue
AILE146
AILE147
AARG149
ATYR200
ATLA402

site_idAC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE SB4 B 401
ChainResidue
BSER32
BVAL38
BALA51
BLEU104
BVAL105
BTHR106
BHIS107
BLEU108
BMET109
BASP112
BSER154
BLEU167
BHOH557
BHOH606
BHOH661
LGLN412

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 402
ChainResidue
BLYS118
BTRP187
BTHR221
BHOH604
DARG10

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO B 403
ChainResidue
BASP124
BASP125
BGLN128
BHOH538
LTYR392
LSER393

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 404
ChainResidue
BASN278
BLEU280
BALA306
BTYR307
BHOH684

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 405
ChainResidue
BVAL239
BGLY240
BTHR241
BPRO242
BLEU291
BHOH525
BHOH664

site_idBC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE SB4 C 401
ChainResidue
CSER32
CGLY33
CVAL38
CALA51
CLEU104
CVAL105
CTHR106
CHIS107
CLEU108
CMET109
CASP112
CLEU167
CHOH612
CHOH615

site_idBC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE EDO C 402
ChainResidue
CGLN25

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO C 403
ChainResidue
AARG10
CLYS118
CTRP187
CTHR221
CHOH507

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO C 404
ChainResidue
CPRO279
CVAL282
CASP283
CGLU286
BHOH653
BHOH674

site_idBC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO C 405
ChainResidue
AHOH535
CSER32
CGLY33
CGLY36
CHOH680

site_idBC7
Number of Residues14
DetailsBINDING SITE FOR RESIDUE SB4 D 401
ChainResidue
BHOH595
DSER32
DGLY33
DALA51
DLEU104
DVAL105
DTHR106
DHIS107
DLEU108
DMET109
DASP112
DSER154
DLEU167
DHOH514

site_idBC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE TLA D 402
ChainResidue
AARG330
AASP331
DARG149
DARG173
DHIS174
DTRP197
DTYR200
DEDO406
DHOH657

site_idBC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO D 403
ChainResidue
BARG10
DLYS118
DTRP187
DTHR221
DHOH552

site_idCC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO D 404
ChainResidue
DVAL239
DGLY240
DTHR241
DPRO242
DLEU291

site_idCC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO D 405
ChainResidue
DARG237
DHOH578
DHOH726
LSER406
LHOH512

site_idCC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO D 406
ChainResidue
DILE147
DARG149
DTYR200
DTLA402

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK
ChainResidueDetails
AVAL30-LYS54

site_idPS01351
Number of Residues104
DetailsMAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
ChainResidueDetails
APHE59-CYS162

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:Q15750
ChainResidueDetails
KSER393
LSER393
MSER393
NSER393

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AVAL30
ALYS53
BVAL30
BLYS53
CVAL30
CLYS53
DVAL30
DLYS53

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16539
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q16539
ChainResidueDetails
ATHR16
BTHR16
CTHR16
DTHR16

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q16539
ChainResidueDetails
ALYS53
ALYS152
BLYS53
BLYS152
CLYS53
CLYS152
DLYS53
DLYS152

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000250
ChainResidueDetails
ATHR180
BTHR180
CTHR180
DTHR180

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis => ECO:0000250
ChainResidueDetails
ATYR182
BTYR182
CTYR182
DTYR182

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000250|UniProtKB:Q16539
ChainResidueDetails
ATYR323
BTYR323
CTYR323
DTYR323

221716

PDB entries from 2024-06-26

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