4LOP

Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000077	biological_process	DNA damage checkpoint signaling
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0000902	biological_process	cell morphogenesis
A	0000922	cellular_component	spindle pole
A	0001502	biological_process	cartilage condensation
A	0001525	biological_process	angiogenesis
A	0001649	biological_process	osteoblast differentiation
A	0001890	biological_process	placenta development
A	0002021	biological_process	response to dietary excess
A	0002062	biological_process	chondrocyte differentiation
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
A	0007519	biological_process	skeletal muscle tissue development
A	0010628	biological_process	positive regulation of gene expression
A	0010831	biological_process	positive regulation of myotube differentiation
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0019395	biological_process	fatty acid oxidation
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0030278	biological_process	regulation of ossification
A	0030316	biological_process	osteoclast differentiation
A	0031098	biological_process	stress-activated protein kinase signaling cascade
A	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
A	0032495	biological_process	response to muramyl dipeptide
A	0032496	biological_process	response to lipopolysaccharide
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032868	biological_process	response to insulin
A	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
A	0035331	biological_process	negative regulation of hippo signaling
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0035994	biological_process	response to muscle stretch
A	0038066	biological_process	p38MAPK cascade
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042770	biological_process	signal transduction in response to DNA damage
A	0045648	biological_process	positive regulation of erythrocyte differentiation
A	0045663	biological_process	positive regulation of myoblast differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046326	biological_process	positive regulation of D-glucose import
A	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
A	0048273	molecular_function	mitogen-activated protein kinase p38 binding
A	0051146	biological_process	striated muscle cell differentiation
A	0051403	biological_process	stress-activated MAPK cascade
A	0051525	molecular_function	NFAT protein binding
A	0051604	biological_process	protein maturation
A	0060043	biological_process	regulation of cardiac muscle cell proliferation
A	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
A	0060348	biological_process	bone development
A	0070269	biological_process	pyroptotic inflammatory response
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071223	biological_process	cellular response to lipoteichoic acid
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071479	biological_process	cellular response to ionizing radiation
A	0071493	biological_process	cellular response to UV-B
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0090336	biological_process	positive regulation of brown fat cell differentiation
A	0090400	biological_process	stress-induced premature senescence
A	0098586	biological_process	cellular response to virus
A	0098978	cellular_component	glutamatergic synapse
A	0099179	biological_process	regulation of synaptic membrane adhesion
A	0106310	molecular_function	protein serine kinase activity
A	1900015	biological_process	regulation of cytokine production involved in inflammatory response
A	1901741	biological_process	positive regulation of myoblast fusion
A	1904784	biological_process	NLRP1 inflammasome complex assembly
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
B	0000077	biological_process	DNA damage checkpoint signaling
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0000902	biological_process	cell morphogenesis
B	0000922	cellular_component	spindle pole
B	0001502	biological_process	cartilage condensation
B	0001525	biological_process	angiogenesis
B	0001649	biological_process	osteoblast differentiation
B	0001890	biological_process	placenta development
B	0002021	biological_process	response to dietary excess
B	0002062	biological_process	chondrocyte differentiation
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
B	0007519	biological_process	skeletal muscle tissue development
B	0010628	biological_process	positive regulation of gene expression
B	0010831	biological_process	positive regulation of myotube differentiation
B	0016301	molecular_function	kinase activity
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0019395	biological_process	fatty acid oxidation
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0030278	biological_process	regulation of ossification
B	0030316	biological_process	osteoclast differentiation
B	0031098	biological_process	stress-activated protein kinase signaling cascade
B	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
B	0032495	biological_process	response to muramyl dipeptide
B	0032496	biological_process	response to lipopolysaccharide
B	0032735	biological_process	positive regulation of interleukin-12 production
B	0032868	biological_process	response to insulin
B	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
B	0035331	biological_process	negative regulation of hippo signaling
B	0035556	biological_process	intracellular signal transduction
B	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
B	0035994	biological_process	response to muscle stretch
B	0038066	biological_process	p38MAPK cascade
B	0042307	biological_process	positive regulation of protein import into nucleus
B	0042770	biological_process	signal transduction in response to DNA damage
B	0045648	biological_process	positive regulation of erythrocyte differentiation
B	0045663	biological_process	positive regulation of myoblast differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046326	biological_process	positive regulation of D-glucose import
B	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
B	0048273	molecular_function	mitogen-activated protein kinase p38 binding
B	0051146	biological_process	striated muscle cell differentiation
B	0051403	biological_process	stress-activated MAPK cascade
B	0051525	molecular_function	NFAT protein binding
B	0051604	biological_process	protein maturation
B	0060043	biological_process	regulation of cardiac muscle cell proliferation
B	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
B	0060348	biological_process	bone development
B	0070269	biological_process	pyroptotic inflammatory response
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071223	biological_process	cellular response to lipoteichoic acid
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0071479	biological_process	cellular response to ionizing radiation
B	0071493	biological_process	cellular response to UV-B
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0090336	biological_process	positive regulation of brown fat cell differentiation
B	0090400	biological_process	stress-induced premature senescence
B	0098586	biological_process	cellular response to virus
B	0098978	cellular_component	glutamatergic synapse
B	0099179	biological_process	regulation of synaptic membrane adhesion
B	0106310	molecular_function	protein serine kinase activity
B	1900015	biological_process	regulation of cytokine production involved in inflammatory response
B	1901741	biological_process	positive regulation of myoblast fusion
B	1904784	biological_process	NLRP1 inflammasome complex assembly
B	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0000902	biological_process	cell morphogenesis
C	0000922	cellular_component	spindle pole
C	0001502	biological_process	cartilage condensation
C	0001525	biological_process	angiogenesis
C	0001649	biological_process	osteoblast differentiation
C	0001890	biological_process	placenta development
C	0002021	biological_process	response to dietary excess
C	0002062	biological_process	chondrocyte differentiation
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004707	molecular_function	MAP kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006468	biological_process	protein phosphorylation
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
C	0007519	biological_process	skeletal muscle tissue development
C	0010628	biological_process	positive regulation of gene expression
C	0010831	biological_process	positive regulation of myotube differentiation
C	0016301	molecular_function	kinase activity
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0019395	biological_process	fatty acid oxidation
C	0019899	molecular_function	enzyme binding
C	0019903	molecular_function	protein phosphatase binding
C	0030278	biological_process	regulation of ossification
C	0030316	biological_process	osteoclast differentiation
C	0031098	biological_process	stress-activated protein kinase signaling cascade
C	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
C	0032495	biological_process	response to muramyl dipeptide
C	0032496	biological_process	response to lipopolysaccharide
C	0032735	biological_process	positive regulation of interleukin-12 production
C	0032868	biological_process	response to insulin
C	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
C	0035331	biological_process	negative regulation of hippo signaling
C	0035556	biological_process	intracellular signal transduction
C	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
C	0035994	biological_process	response to muscle stretch
C	0038066	biological_process	p38MAPK cascade
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0042770	biological_process	signal transduction in response to DNA damage
C	0045648	biological_process	positive regulation of erythrocyte differentiation
C	0045663	biological_process	positive regulation of myoblast differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046326	biological_process	positive regulation of D-glucose import
C	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
C	0048273	molecular_function	mitogen-activated protein kinase p38 binding
C	0051146	biological_process	striated muscle cell differentiation
C	0051403	biological_process	stress-activated MAPK cascade
C	0051525	molecular_function	NFAT protein binding
C	0051604	biological_process	protein maturation
C	0060043	biological_process	regulation of cardiac muscle cell proliferation
C	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
C	0060348	biological_process	bone development
C	0070269	biological_process	pyroptotic inflammatory response
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0071223	biological_process	cellular response to lipoteichoic acid
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0071479	biological_process	cellular response to ionizing radiation
C	0071493	biological_process	cellular response to UV-B
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0090336	biological_process	positive regulation of brown fat cell differentiation
C	0090400	biological_process	stress-induced premature senescence
C	0098586	biological_process	cellular response to virus
C	0098978	cellular_component	glutamatergic synapse
C	0099179	biological_process	regulation of synaptic membrane adhesion
C	0106310	molecular_function	protein serine kinase activity
C	1900015	biological_process	regulation of cytokine production involved in inflammatory response
C	1901741	biological_process	positive regulation of myoblast fusion
C	1904784	biological_process	NLRP1 inflammasome complex assembly
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
D	0000077	biological_process	DNA damage checkpoint signaling
D	0000165	biological_process	MAPK cascade
D	0000166	molecular_function	nucleotide binding
D	0000902	biological_process	cell morphogenesis
D	0000922	cellular_component	spindle pole
D	0001502	biological_process	cartilage condensation
D	0001525	biological_process	angiogenesis
D	0001649	biological_process	osteoblast differentiation
D	0001890	biological_process	placenta development
D	0002021	biological_process	response to dietary excess
D	0002062	biological_process	chondrocyte differentiation
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004707	molecular_function	MAP kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
D	0007519	biological_process	skeletal muscle tissue development
D	0010628	biological_process	positive regulation of gene expression
D	0010831	biological_process	positive regulation of myotube differentiation
D	0016301	molecular_function	kinase activity
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0019395	biological_process	fatty acid oxidation
D	0019899	molecular_function	enzyme binding
D	0019903	molecular_function	protein phosphatase binding
D	0030278	biological_process	regulation of ossification
D	0030316	biological_process	osteoclast differentiation
D	0031098	biological_process	stress-activated protein kinase signaling cascade
D	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
D	0032495	biological_process	response to muramyl dipeptide
D	0032496	biological_process	response to lipopolysaccharide
D	0032735	biological_process	positive regulation of interleukin-12 production
D	0032868	biological_process	response to insulin
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
D	0035331	biological_process	negative regulation of hippo signaling
D	0035556	biological_process	intracellular signal transduction
D	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
D	0035994	biological_process	response to muscle stretch
D	0038066	biological_process	p38MAPK cascade
D	0042307	biological_process	positive regulation of protein import into nucleus
D	0042770	biological_process	signal transduction in response to DNA damage
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0045663	biological_process	positive regulation of myoblast differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046326	biological_process	positive regulation of D-glucose import
D	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
D	0048273	molecular_function	mitogen-activated protein kinase p38 binding
D	0051146	biological_process	striated muscle cell differentiation
D	0051403	biological_process	stress-activated MAPK cascade
D	0051525	molecular_function	NFAT protein binding
D	0051604	biological_process	protein maturation
D	0060043	biological_process	regulation of cardiac muscle cell proliferation
D	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
D	0060348	biological_process	bone development
D	0070269	biological_process	pyroptotic inflammatory response
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0071223	biological_process	cellular response to lipoteichoic acid
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0071479	biological_process	cellular response to ionizing radiation
D	0071493	biological_process	cellular response to UV-B
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090336	biological_process	positive regulation of brown fat cell differentiation
D	0090400	biological_process	stress-induced premature senescence
D	0098586	biological_process	cellular response to virus
D	0098978	cellular_component	glutamatergic synapse
D	0099179	biological_process	regulation of synaptic membrane adhesion
D	0106310	molecular_function	protein serine kinase activity
D	1900015	biological_process	regulation of cytokine production involved in inflammatory response
D	1901741	biological_process	positive regulation of myoblast fusion
D	1904784	biological_process	NLRP1 inflammasome complex assembly
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SB4 A 401

Chain	Residue
A	SER32
A	ASP112
A	LEU167
A	HOH670
A	HOH721
A	VAL38
A	ALA51
A	LEU104
A	VAL105
A	THR106
A	HIS107
A	LEU108
A	MET109

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TLA A 402

Chain	Residue
A	ARG149
A	ARG173
A	HIS174
A	TRP197
A	TYR200
A	EDO405
A	HOH597
A	HOH703
D	ARG330
D	ASP331

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	LYS118
A	TRP187
A	THR221
A	HOH547
C	ARG10

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 404

Chain	Residue
A	THR46
A	GLY47
A	HIS48
A	GLU253
A	SER254

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 405

Chain	Residue
A	ILE146
A	ILE147
A	ARG149
A	TYR200
A	TLA402

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SB4 B 401

Chain	Residue
B	SER32
B	VAL38
B	ALA51
B	LEU104
B	VAL105
B	THR106
B	HIS107
B	LEU108
B	MET109
B	ASP112
B	SER154
B	LEU167
B	HOH557
B	HOH606
B	HOH661
L	GLN412

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 402

Chain	Residue
B	LYS118
B	TRP187
B	THR221
B	HOH604
D	ARG10

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 403

Chain	Residue
B	ASP124
B	ASP125
B	GLN128
B	HOH538
L	TYR392
L	SER393

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 404

Chain	Residue
B	ASN278
B	LEU280
B	ALA306
B	TYR307
B	HOH684

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 405

Chain	Residue
B	VAL239
B	GLY240
B	THR241
B	PRO242
B	LEU291
B	HOH525
B	HOH664

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SB4 C 401

Chain	Residue
C	SER32
C	GLY33
C	VAL38
C	ALA51
C	LEU104
C	VAL105
C	THR106
C	HIS107
C	LEU108
C	MET109
C	ASP112
C	LEU167
C	HOH612
C	HOH615

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO C 402

Chain	Residue
C	GLN25

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 403

Chain	Residue
A	ARG10
C	LYS118
C	TRP187
C	THR221
C	HOH507

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 404

Chain	Residue
C	PRO279
C	VAL282
C	ASP283
C	GLU286
B	HOH653
B	HOH674

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 405

Chain	Residue
A	HOH535
C	SER32
C	GLY33
C	GLY36
C	HOH680

---

site_id	BC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SB4 D 401

Chain	Residue
B	HOH595
D	SER32
D	GLY33
D	ALA51
D	LEU104
D	VAL105
D	THR106
D	HIS107
D	LEU108
D	MET109
D	ASP112
D	SER154
D	LEU167
D	HOH514

---

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TLA D 402

Chain	Residue
A	ARG330
A	ASP331
D	ARG149
D	ARG173
D	HIS174
D	TRP197
D	TYR200
D	EDO406
D	HOH657

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 403

Chain	Residue
B	ARG10
D	LYS118
D	TRP187
D	THR221
D	HOH552

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 404

Chain	Residue
D	VAL239
D	GLY240
D	THR241
D	PRO242
D	LEU291

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 405

Chain	Residue
D	ARG237
D	HOH578
D	HOH726
L	SER406
L	HOH512

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 406

Chain	Residue
D	ILE147
D	ARG149
D	TYR200
D	TLA402

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK

Chain	Residue	Details
A	VAL30-LYS54

---

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC

Chain	Residue	Details
A	PHE59-CYS162

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	852
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"Q15750","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---