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4LLY

Crystal structure of Pertuzumab Clambda Fab with variable and constant domain redesigns (VRD2 and CRD2) at 1.6A

Functional Information from GO Data
ChainGOidnamespacecontents
B0002250biological_processadaptive immune response
B0003823molecular_functionantigen binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0016064biological_processimmunoglobulin mediated immune response
B0019814cellular_componentimmunoglobulin complex
B0070062cellular_componentextracellular exosome
B0071735cellular_componentIgG immunoglobulin complex
B0072562cellular_componentblood microparticle
D0002250biological_processadaptive immune response
D0003823molecular_functionantigen binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0016064biological_processimmunoglobulin mediated immune response
D0019814cellular_componentimmunoglobulin complex
D0070062cellular_componentextracellular exosome
D0071735cellular_componentIgG immunoglobulin complex
D0072562cellular_componentblood microparticle
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 501
ChainResidue
AALA88
ASER118
ASER119
AGLY139
AHOH603
AHOH615
AHOH716
AHOH734

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 301
ChainResidue
BLYS39
BLYS42
BHOH446
BHOH473
BASP38

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 302
ChainResidue
ALYS135
ATHR137
BLYS205
BHOH420
BHOH441
CTHR122
CSER209
CHOH613

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL C 501
ChainResidue
CALA88
CSER118
CSER119
CGLY139
CHOH601
CHOH603
CHOH704
CHOH709

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL C 502
ChainResidue
ATHR122
ASER209
AHOH604
CLYS135
CTHR137
CSER138
CHOH625
DLYS205
DHOH331

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
ChainResidueDetails
BTYR192-HIS198
ATYR200-HIS206

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PDB entries from 2024-07-31

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