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4LLU

Structure of Pertuzumab Fab with light chain Clambda at 2.16A

Functional Information from GO Data
ChainGOidnamespacecontents
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0003823molecular_functionantigen binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0016064biological_processimmunoglobulin mediated immune response
B0019814cellular_componentimmunoglobulin complex
B0070062cellular_componentextracellular exosome
B0071735cellular_componentIgG immunoglobulin complex
B0072562cellular_componentblood microparticle
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0003823molecular_functionantigen binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0016064biological_processimmunoglobulin mediated immune response
D0019814cellular_componentimmunoglobulin complex
D0070062cellular_componentextracellular exosome
D0071735cellular_componentIgG immunoglobulin complex
D0072562cellular_componentblood microparticle
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 301
ChainResidue
ASER7
AGLY8
ALYS201

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ACT B 301
ChainResidue
ALYS209
BALA112
BALA113
BHIS198
BHOH411
BHOH442

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 C 301
ChainResidue
AGLU1
CARG94
CTYR102
DHOH444

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 301
ChainResidue
ASER25
AGLY26
AASN76
DGLY57

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
ATYR194-HIS200
BTYR192-HIS198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues188
DetailsDomain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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