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4LI0

Crystal structure of GDP-bound Rab8:GRAB

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
B0003924molecular_functionGTPase activity
B0005525molecular_functionGTP binding
C0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005085molecular_functionguanyl-nucleotide exchange factor activity
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GDP A 200
ChainResidue
AASP16
AVAL125
ASER151
AALA152
ALYS153
AGLY18
AVAL19
AGLY20
ALYS21
ATHR22
ACYS23
ALYS122
AASP124

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GDP B 200
ChainResidue
BASP16
BGLY18
BVAL19
BGLY20
BLYS21
BTHR22
BCYS23
BASN121
BLYS122
BASP124
BVAL125
BSER151
BALA152
BLYS153

Functional Information from PROSITE/UniProt
site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKtcV
ChainResidueDetails
ALEU11-VAL24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:27552051, ECO:0007744|PDB:5SZI
ChainResidueDetails
ASER17
AASN34
AASN121
BSER17
BASN34
BASN121

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9H0U4, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:5SZI
ChainResidueDetails
AASP63
AALA152
BASP63
BALA152

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by LRRK2 => ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:30209220, ECO:0000269|PubMed:30398148
ChainResidueDetails
ATHR72
BTHR72

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER181
BSER181

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PDB entries from 2024-11-13

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