4LFI
Crystal structure of scCK2 alpha in complex with GMPPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000028 | biological_process | ribosomal small subunit assembly |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| A | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007535 | biological_process | donor selection |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030490 | biological_process | maturation of SSU-rRNA |
| A | 0032040 | cellular_component | small-subunit processome |
| A | 0032545 | cellular_component | CURI complex |
| A | 0034456 | cellular_component | UTP-C complex |
| A | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000028 | biological_process | ribosomal small subunit assembly |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005956 | cellular_component | protein kinase CK2 complex |
| B | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| B | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006974 | biological_process | DNA damage response |
| B | 0007535 | biological_process | donor selection |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030490 | biological_process | maturation of SSU-rRNA |
| B | 0032040 | cellular_component | small-subunit processome |
| B | 0032545 | cellular_component | CURI complex |
| B | 0034456 | cellular_component | UTP-C complex |
| B | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE GNP A 401 |
| Chain | Residue |
| A | GLY47 |
| A | VAL155 |
| A | ASN157 |
| A | ASP195 |
| A | LYS197 |
| A | HIS199 |
| A | ASN200 |
| A | MET202 |
| A | ILE213 |
| A | ASP214 |
| A | MN402 |
| A | ARG48 |
| A | MN403 |
| A | GOL404 |
| A | HOH503 |
| A | HOH506 |
| A | HOH551 |
| A | HOH576 |
| A | HOH615 |
| A | HOH619 |
| A | HOH624 |
| A | HOH640 |
| A | GLY49 |
| A | HOH659 |
| A | LYS50 |
| A | TYR51 |
| A | SER52 |
| A | VAL54 |
| A | VAL67 |
| A | LYS69 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 402 |
| Chain | Residue |
| A | ASN200 |
| A | ASP214 |
| A | GNP401 |
| A | HOH506 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 403 |
| Chain | Residue |
| A | ASP214 |
| A | GNP401 |
| A | HOH539 |
| A | HOH551 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | VAL46 |
| A | ASN157 |
| A | ASP159 |
| A | GNP401 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 405 |
| Chain | Residue |
| A | ARG81 |
| A | ARG194 |
| A | ASN228 |
| A | HOH530 |
| A | HOH651 |
| A | HOH695 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 406 |
| Chain | Residue |
| A | ARG230 |
| A | ARG234 |
| A | ASN277 |
| A | HOH589 |
| A | HOH668 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 407 |
| Chain | Residue |
| A | LYS166 |
| A | HOH609 |
| A | HOH710 |
| B | ARG161 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 408 |
| Chain | Residue |
| A | ARG316 |
| A | PRO318 |
| A | TRP319 |
| A | HIS320 |
| A | ILE337 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 409 |
| Chain | Residue |
| A | ARG268 |
| A | LYS317 |
| A | ARG321 |
| B | ASN324 |
| B | ASP325 |
| site_id | BC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE GNP B 401 |
| Chain | Residue |
| B | GLY47 |
| B | ARG48 |
| B | GLY49 |
| B | LYS50 |
| B | TYR51 |
| B | SER52 |
| B | VAL54 |
| B | VAL67 |
| B | LYS69 |
| B | VAL155 |
| B | ASN157 |
| B | ASP195 |
| B | LYS197 |
| B | HIS199 |
| B | ASN200 |
| B | MET202 |
| B | ILE213 |
| B | ASP214 |
| B | MN402 |
| B | MN403 |
| B | GOL404 |
| B | HOH501 |
| B | HOH503 |
| B | HOH538 |
| B | HOH552 |
| B | HOH566 |
| B | HOH609 |
| B | HOH622 |
| B | HOH633 |
| B | HOH635 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 402 |
| Chain | Residue |
| B | HOH538 |
| B | HOH550 |
| B | ASP214 |
| B | GNP401 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 403 |
| Chain | Residue |
| B | ASN200 |
| B | ASP214 |
| B | GNP401 |
| B | HOH503 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| B | VAL46 |
| B | ASN157 |
| B | ASP159 |
| B | GNP401 |
| B | HOH635 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 405 |
| Chain | Residue |
| B | ARG81 |
| B | ARG194 |
| B | ASN228 |
| B | HOH527 |
| B | HOH673 |
| B | HOH699 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 406 |
| Chain | Residue |
| A | ASN324 |
| A | ASP325 |
| B | ARG268 |
| B | LYS317 |
| B | ARG321 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 407 |
| Chain | Residue |
| A | ARG161 |
| B | LYS166 |
| B | HOH640 |
| B | HOH680 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 408 |
| Chain | Residue |
| B | ARG316 |
| B | PRO318 |
| B | TRP319 |
| B | HIS320 |
| B | HOH718 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 409 |
| Chain | Residue |
| B | ARG230 |
| B | ARG234 |
| B | ASN277 |
| B | HOH617 |
| B | HOH669 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFqGvkldskvk..........IVIK |
| Chain | Residue | Details |
| A | VAL46-LYS69 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE191-ILE203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 646 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
