4LFI
Crystal structure of scCK2 alpha in complex with GMPPNP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000028 | biological_process | ribosomal small subunit assembly |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005730 | cellular_component | nucleolus |
A | 0005829 | cellular_component | cytosol |
A | 0005956 | cellular_component | protein kinase CK2 complex |
A | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
A | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006974 | biological_process | DNA damage response |
A | 0007535 | biological_process | donor selection |
A | 0030490 | biological_process | maturation of SSU-rRNA |
A | 0032040 | cellular_component | small-subunit processome |
A | 0032545 | cellular_component | CURI complex |
A | 0034456 | cellular_component | UTP-C complex |
A | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
A | 0106310 | molecular_function | protein serine kinase activity |
B | 0000028 | biological_process | ribosomal small subunit assembly |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005730 | cellular_component | nucleolus |
B | 0005829 | cellular_component | cytosol |
B | 0005956 | cellular_component | protein kinase CK2 complex |
B | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
B | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
B | 0006468 | biological_process | protein phosphorylation |
B | 0006974 | biological_process | DNA damage response |
B | 0007535 | biological_process | donor selection |
B | 0030490 | biological_process | maturation of SSU-rRNA |
B | 0032040 | cellular_component | small-subunit processome |
B | 0032545 | cellular_component | CURI complex |
B | 0034456 | cellular_component | UTP-C complex |
B | 0042790 | biological_process | nucleolar large rRNA transcription by RNA polymerase I |
B | 0051726 | biological_process | regulation of cell cycle |
B | 0060962 | biological_process | regulation of ribosomal protein gene transcription by RNA polymerase II |
B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE GNP A 401 |
Chain | Residue |
A | GLY47 |
A | VAL155 |
A | ASN157 |
A | ASP195 |
A | LYS197 |
A | HIS199 |
A | ASN200 |
A | MET202 |
A | ILE213 |
A | ASP214 |
A | MN402 |
A | ARG48 |
A | MN403 |
A | GOL404 |
A | HOH503 |
A | HOH506 |
A | HOH551 |
A | HOH576 |
A | HOH615 |
A | HOH619 |
A | HOH624 |
A | HOH640 |
A | GLY49 |
A | HOH659 |
A | LYS50 |
A | TYR51 |
A | SER52 |
A | VAL54 |
A | VAL67 |
A | LYS69 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 402 |
Chain | Residue |
A | ASN200 |
A | ASP214 |
A | GNP401 |
A | HOH506 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 403 |
Chain | Residue |
A | ASP214 |
A | GNP401 |
A | HOH539 |
A | HOH551 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 404 |
Chain | Residue |
A | VAL46 |
A | ASN157 |
A | ASP159 |
A | GNP401 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 405 |
Chain | Residue |
A | ARG81 |
A | ARG194 |
A | ASN228 |
A | HOH530 |
A | HOH651 |
A | HOH695 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 406 |
Chain | Residue |
A | ARG230 |
A | ARG234 |
A | ASN277 |
A | HOH589 |
A | HOH668 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 407 |
Chain | Residue |
A | LYS166 |
A | HOH609 |
A | HOH710 |
B | ARG161 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 408 |
Chain | Residue |
A | ARG316 |
A | PRO318 |
A | TRP319 |
A | HIS320 |
A | ILE337 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 409 |
Chain | Residue |
A | ARG268 |
A | LYS317 |
A | ARG321 |
B | ASN324 |
B | ASP325 |
site_id | BC1 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE GNP B 401 |
Chain | Residue |
B | GLY47 |
B | ARG48 |
B | GLY49 |
B | LYS50 |
B | TYR51 |
B | SER52 |
B | VAL54 |
B | VAL67 |
B | LYS69 |
B | VAL155 |
B | ASN157 |
B | ASP195 |
B | LYS197 |
B | HIS199 |
B | ASN200 |
B | MET202 |
B | ILE213 |
B | ASP214 |
B | MN402 |
B | MN403 |
B | GOL404 |
B | HOH501 |
B | HOH503 |
B | HOH538 |
B | HOH552 |
B | HOH566 |
B | HOH609 |
B | HOH622 |
B | HOH633 |
B | HOH635 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B 402 |
Chain | Residue |
B | HOH538 |
B | HOH550 |
B | ASP214 |
B | GNP401 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B 403 |
Chain | Residue |
B | ASN200 |
B | ASP214 |
B | GNP401 |
B | HOH503 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 404 |
Chain | Residue |
B | VAL46 |
B | ASN157 |
B | ASP159 |
B | GNP401 |
B | HOH635 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 405 |
Chain | Residue |
B | ARG81 |
B | ARG194 |
B | ASN228 |
B | HOH527 |
B | HOH673 |
B | HOH699 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 406 |
Chain | Residue |
A | ASN324 |
A | ASP325 |
B | ARG268 |
B | LYS317 |
B | ARG321 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 407 |
Chain | Residue |
A | ARG161 |
B | LYS166 |
B | HOH640 |
B | HOH680 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 408 |
Chain | Residue |
B | ARG316 |
B | PRO318 |
B | TRP319 |
B | HIS320 |
B | HOH718 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 409 |
Chain | Residue |
B | ARG230 |
B | ARG234 |
B | ASN277 |
B | HOH617 |
B | HOH669 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFqGvkldskvk..........IVIK |
Chain | Residue | Details |
A | VAL46-LYS69 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
Chain | Residue | Details |
A | ILE191-ILE203 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP195 | |
B | ASP195 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | VAL46 | |
A | LYS69 | |
B | VAL46 | |
B | LYS69 |