Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4LBQ

Crystal structure of mouse galectin-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002317	biological_process	plasma cell differentiation
A	0005515	molecular_function	protein binding
A	0005534	molecular_function	galactose binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0007157	biological_process	heterophilic cell-cell adhesion
A	0007165	biological_process	signal transduction
A	0009986	cellular_component	cell surface
A	0010812	biological_process	negative regulation of cell-substrate adhesion
A	0010977	biological_process	negative regulation of neuron projection development
A	0030246	molecular_function	carbohydrate binding
A	0030395	molecular_function	lactose binding
A	0031012	cellular_component	extracellular matrix
A	0031295	biological_process	T cell costimulation
A	0034120	biological_process	positive regulation of erythrocyte aggregation
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043236	molecular_function	laminin binding
A	0045185	biological_process	maintenance of protein location
A	0045445	biological_process	myoblast differentiation
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0048018	molecular_function	receptor ligand activity
A	0050729	biological_process	positive regulation of inflammatory response
A	0098609	biological_process	cell-cell adhesion
A	1990724	cellular_component	galectin complex
A	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
B	0002317	biological_process	plasma cell differentiation
B	0005515	molecular_function	protein binding
B	0005534	molecular_function	galactose binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0007157	biological_process	heterophilic cell-cell adhesion
B	0007165	biological_process	signal transduction
B	0009986	cellular_component	cell surface
B	0010812	biological_process	negative regulation of cell-substrate adhesion
B	0010977	biological_process	negative regulation of neuron projection development
B	0030246	molecular_function	carbohydrate binding
B	0030395	molecular_function	lactose binding
B	0031012	cellular_component	extracellular matrix
B	0031295	biological_process	T cell costimulation
B	0034120	biological_process	positive regulation of erythrocyte aggregation
B	0042802	molecular_function	identical protein binding
B	0043065	biological_process	positive regulation of apoptotic process
B	0043236	molecular_function	laminin binding
B	0045185	biological_process	maintenance of protein location
B	0045445	biological_process	myoblast differentiation
B	0046598	biological_process	positive regulation of viral entry into host cell
B	0048018	molecular_function	receptor ligand activity
B	0050729	biological_process	positive regulation of inflammatory response
B	0098609	biological_process	cell-cell adhesion
B	1990724	cellular_component	galectin complex
B	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
C	0002317	biological_process	plasma cell differentiation
C	0005515	molecular_function	protein binding
C	0005534	molecular_function	galactose binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006915	biological_process	apoptotic process
C	0007157	biological_process	heterophilic cell-cell adhesion
C	0007165	biological_process	signal transduction
C	0009986	cellular_component	cell surface
C	0010812	biological_process	negative regulation of cell-substrate adhesion
C	0010977	biological_process	negative regulation of neuron projection development
C	0030246	molecular_function	carbohydrate binding
C	0030395	molecular_function	lactose binding
C	0031012	cellular_component	extracellular matrix
C	0031295	biological_process	T cell costimulation
C	0034120	biological_process	positive regulation of erythrocyte aggregation
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043236	molecular_function	laminin binding
C	0045185	biological_process	maintenance of protein location
C	0045445	biological_process	myoblast differentiation
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0048018	molecular_function	receptor ligand activity
C	0050729	biological_process	positive regulation of inflammatory response
C	0098609	biological_process	cell-cell adhesion
C	1990724	cellular_component	galectin complex
C	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment
D	0002317	biological_process	plasma cell differentiation
D	0005515	molecular_function	protein binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006915	biological_process	apoptotic process
D	0007157	biological_process	heterophilic cell-cell adhesion
D	0007165	biological_process	signal transduction
D	0009986	cellular_component	cell surface
D	0010812	biological_process	negative regulation of cell-substrate adhesion
D	0010977	biological_process	negative regulation of neuron projection development
D	0030246	molecular_function	carbohydrate binding
D	0030395	molecular_function	lactose binding
D	0031012	cellular_component	extracellular matrix
D	0031295	biological_process	T cell costimulation
D	0034120	biological_process	positive regulation of erythrocyte aggregation
D	0042802	molecular_function	identical protein binding
D	0043065	biological_process	positive regulation of apoptotic process
D	0043236	molecular_function	laminin binding
D	0045185	biological_process	maintenance of protein location
D	0045445	biological_process	myoblast differentiation
D	0046598	biological_process	positive regulation of viral entry into host cell
D	0048018	molecular_function	receptor ligand activity
D	0050729	biological_process	positive regulation of inflammatory response
D	0098609	biological_process	cell-cell adhesion
D	1990724	cellular_component	galectin complex
D	2000329	biological_process	negative regulation of T-helper 17 cell lineage commitment

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 201

Chain	Residue
A	ASN62
A	TRP69
A	GLU72

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 201

Chain	Residue
B	HIS73
B	PRO110
B	ARG112
C	ARG74

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 201

Chain	Residue
C	ASN62
C	GLU72
C	HIS45
C	ARG49

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 201

Chain	Residue
A	HIS53
D	ASN62
D	TRP69
D	GLU72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	31
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P09382","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	131
Details	Domain: {"description":"Galectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00639","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)