4L9Y
Crystal Structure of Rhodobacter sphaeroides malyl-CoA lyase in complex with magnesium, glyoxylate, and propionyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006107 | biological_process | oxaloacetate metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0043959 | molecular_function | L-erythro-3-methylmalyl-CoA lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| A | 0050083 | molecular_function | malyl-CoA lyase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0006107 | biological_process | oxaloacetate metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0043959 | molecular_function | L-erythro-3-methylmalyl-CoA lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| B | 0050083 | molecular_function | malyl-CoA lyase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0006107 | biological_process | oxaloacetate metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0043959 | molecular_function | L-erythro-3-methylmalyl-CoA lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| C | 0050083 | molecular_function | malyl-CoA lyase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0006107 | biological_process | oxaloacetate metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0043959 | molecular_function | L-erythro-3-methylmalyl-CoA lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| D | 0050083 | molecular_function | malyl-CoA lyase activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0006107 | biological_process | oxaloacetate metabolic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0043959 | molecular_function | L-erythro-3-methylmalyl-CoA lyase activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| E | 0050083 | molecular_function | malyl-CoA lyase activity |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0006107 | biological_process | oxaloacetate metabolic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0043959 | molecular_function | L-erythro-3-methylmalyl-CoA lyase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| F | 0050083 | molecular_function | malyl-CoA lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | GLU141 |
| A | ASP168 |
| A | HOH501 |
| A | HOH519 |
| A | HOH546 |
| A | HOH602 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 402 |
| Chain | Residue |
| A | ASP168 |
| A | HOH501 |
| A | GLY165 |
| A | ALA166 |
| A | ALA167 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 1VU B 401 |
| Chain | Residue |
| A | ASP299 |
| B | PHE19 |
| B | GLY20 |
| B | ARG24 |
| B | LYS30 |
| B | MET31 |
| B | ARG76 |
| B | ALA167 |
| B | ILE180 |
| B | ILE251 |
| B | HIS252 |
| B | PRO253 |
| B | GLV402 |
| B | HOH510 |
| B | HOH661 |
| B | HOH691 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLV B 402 |
| Chain | Residue |
| B | ARG76 |
| B | GLU141 |
| B | GLY165 |
| B | ALA166 |
| B | ALA167 |
| B | ASP168 |
| B | PRO223 |
| B | 1VU401 |
| B | MG403 |
| B | HOH510 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 403 |
| Chain | Residue |
| B | ASP45 |
| B | GLU141 |
| B | ASP168 |
| B | GLV402 |
| B | HOH510 |
| B | HOH724 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 401 |
| Chain | Residue |
| C | ASP45 |
| C | GLU141 |
| C | ASP168 |
| C | HOH502 |
| C | HOH503 |
| C | HOH507 |
| C | HOH763 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL C 402 |
| Chain | Residue |
| C | GLY165 |
| C | ALA166 |
| C | ALA167 |
| C | ASP168 |
| C | HOH502 |
| C | HOH627 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLV D 401 |
| Chain | Residue |
| D | ARG76 |
| D | GLU141 |
| D | GLY165 |
| D | ALA166 |
| D | ALA167 |
| D | ASP168 |
| D | PRO223 |
| D | TRP249 |
| D | MG402 |
| D | HOH501 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 402 |
| Chain | Residue |
| D | GLU141 |
| D | ASP168 |
| D | GLV401 |
| D | HOH501 |
| D | HOH733 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG E 401 |
| Chain | Residue |
| E | ASP45 |
| E | GLU141 |
| E | ASP168 |
| E | HOH501 |
| E | HOH513 |
| E | HOH724 |
| E | HOH757 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL E 402 |
| Chain | Residue |
| E | GLY165 |
| E | ALA166 |
| E | ALA167 |
| E | ASP168 |
| E | PRO223 |
| E | HOH724 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG F 401 |
| Chain | Residue |
| F | ASP45 |
| F | GLU141 |
| F | ASP168 |
| F | HOH503 |
| F | HOH506 |
| F | HOH526 |
| F | HOH747 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL F 402 |
| Chain | Residue |
| F | GLY165 |
| F | ALA166 |
| F | ALA167 |
| F | ASP168 |
| F | PRO223 |
| F | HOH747 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24206647, ECO:0007744|PDB:4L9Y |
| Chain | Residue | Details |
| A | PHE19 | |
| E | ARG24 | |
| F | PHE19 | |
| F | ARG24 | |
| A | ARG24 | |
| B | PHE19 | |
| B | ARG24 | |
| C | PHE19 | |
| C | ARG24 | |
| D | PHE19 | |
| D | ARG24 | |
| E | PHE19 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24206647, ECO:0007744|PDB:4L9Z |
| Chain | Residue | Details |
| A | LYS30 | |
| D | LYS30 | |
| D | ALA167 | |
| D | ILE251 | |
| E | LYS30 | |
| E | ALA167 | |
| E | ILE251 | |
| F | LYS30 | |
| F | ALA167 | |
| F | ILE251 | |
| A | ALA167 | |
| A | ILE251 | |
| B | LYS30 | |
| B | ALA167 | |
| B | ILE251 | |
| C | LYS30 | |
| C | ALA167 | |
| C | ILE251 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24206647, ECO:0007744|PDB:4L9Y, ECO:0007744|PDB:4L9Z |
| Chain | Residue | Details |
| A | ARG76 | |
| D | ARG76 | |
| D | GLU141 | |
| D | ASP168 | |
| E | ARG76 | |
| E | GLU141 | |
| E | ASP168 | |
| F | ARG76 | |
| F | GLU141 | |
| F | ASP168 | |
| A | GLU141 | |
| A | ASP168 | |
| B | ARG76 | |
| B | GLU141 | |
| B | ASP168 | |
| C | ARG76 | |
| C | GLU141 | |
| C | ASP168 |
