4L44
Crystal structures of human p70S6K1-T389A (form II)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | GLN140 |
| A | LEU386 |
| A | GLY387 |
| A | PHE388 |
| A | ALA389 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | ARG340 |
| A | PRO130 |
| A | ASP134 |
| A | GLU150 |
| A | LYS210 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | ASN274 |
| A | ARG275 |
| A | ARG330 |
| A | HIS331 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 5FI A 404 |
| Chain | Residue |
| A | LEU74 |
| A | GLY75 |
| A | LYS76 |
| A | GLY77 |
| A | TYR79 |
| A | GLY80 |
| A | LYS81 |
| A | VAL82 |
| A | ALA98 |
| A | LYS100 |
| A | LEU102 |
| A | GLU150 |
| A | TYR151 |
| A | LEU152 |
| A | MET202 |
| A | ASP213 |
| A | CYS217 |
| A | LYS218 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 405 |
| Chain | Residue |
| A | CYS217 |
| A | HIS222 |
| A | HIS228 |
| A | CYS231 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 27 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGYGKVFqVrkvtgantgki.......FAMK |
| Chain | Residue | Details |
| A | LEU74-LYS100 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNIML |
| Chain | Residue | Details |
| A | ILE191-LEU203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"19864428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9445476","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by MTOR, NEK6 and NEK7","evidences":[{"source":"PubMed","id":"29236692","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29750193","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
