4L41
Human Lactose synthase: A 2:1 complex between human alpha-lactalbumin and human beta1,4-galactosyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004461 | molecular_function | lactose synthase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005989 | biological_process | lactose biosynthetic process |
| B | 0004461 | molecular_function | lactose synthase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005989 | biological_process | lactose biosynthetic process |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 201 |
| Chain | Residue |
| A | LYS80 |
| A | ASP83 |
| A | ASP85 |
| A | ASP88 |
| A | ASP89 |
| A | HOH302 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 401 |
| Chain | Residue |
| C | ARG339 |
| C | ARG342 |
| C | GLU144 |
| C | PHE145 |
| C | ASN146 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 201 |
| Chain | Residue |
| B | LYS80 |
| B | PHE81 |
| B | ASP83 |
| B | ASP85 |
| B | ASP88 |
| B | ASP89 |
Functional Information from PROSITE/UniProt
| site_id | PS00128 |
| Number of Residues | 19 |
| Details | GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CdisCdkFlddDItddimC |
| Chain | Residue | Details |
| A | CYS74-CYS92 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9537992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8366079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HML","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8366079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9537992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HML","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical; partial","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"1995","firstPage":"119","lastPage":"119","volume":"1","journal":"Protein Sci. 4 Suppl.","title":"An unusual glycosylation site in alpha-lactalbumin from human milk.","authors":["Cavaletto M.","Giuffrida M.G.","Giunta C.","Conti A."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 13 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16497331","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16157350","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19106107","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
