4L17

GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DNQ A 301

Chain	Residue
A	TYR16
A	TYR220
A	HOH424
A	HOH439
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	THR174
A	GLU193
A	MET196

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ARG31
A	LYS52
A	LEU53

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DNQ C 301

Chain	Residue
C	TYR16
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	THR174
C	MET196
C	TYR220

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	ARG64
C	LYS69

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DNQ E 301

Chain	Residue
E	TYR16
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	THR174
E	GLU193
E	THR195
E	MET196
E	TYR220

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 302

Chain	Residue
A	ARG172
E	ARG31
E	HOH413

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site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DNQ G 301

Chain	Residue
G	TYR16
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	GLU193
G	THR195
G	MET196
G	TYR220

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
C	SER142
C	THR143
C	GLU193
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR143
E	GLU193
G	PRO89
A	THR91
G	THR91
G	ARG96
G	SER142
G	THR143
G	GLU193
A	ARG96
A	SER142
A	THR143
A	GLU193
C	PRO89
C	THR91
C	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
G	ARG64
G	ARG148
G	LYS240
A	ARG148
A	LYS240
C	ARG64
C	ARG148
C	LYS240
E	ARG64
E	ARG148
E	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
C	ILE121
E	ILE121
G	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
C	SER150
E	SER150
G	SER150

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
C	SER184
E	SER184
G	SER184

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
C	ASN3
E	ASN3
G	ASN3

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