4KX6
Plasticity of the quinone-binding site of the complex II homolog quinol:fumarate reductase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000104 | molecular_function | succinate dehydrogenase activity |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006113 | biological_process | fermentation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0019645 | biological_process | anaerobic electron transport chain |
| A | 0022900 | biological_process | electron transport chain |
| A | 0044780 | biological_process | bacterial-type flagellum assembly |
| A | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0071949 | molecular_function | FAD binding |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| C | 0016020 | cellular_component | membrane |
| D | 0000104 | molecular_function | succinate dehydrogenase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006106 | biological_process | fumarate metabolic process |
| D | 0006113 | biological_process | fermentation |
| D | 0009061 | biological_process | anaerobic respiration |
| D | 0016020 | cellular_component | membrane |
| D | 0019645 | biological_process | anaerobic electron transport chain |
| D | 0044780 | biological_process | bacterial-type flagellum assembly |
| D | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
| M | 0000104 | molecular_function | succinate dehydrogenase activity |
| M | 0000166 | molecular_function | nucleotide binding |
| M | 0005515 | molecular_function | protein binding |
| M | 0005829 | cellular_component | cytosol |
| M | 0005886 | cellular_component | plasma membrane |
| M | 0006113 | biological_process | fermentation |
| M | 0006974 | biological_process | DNA damage response |
| M | 0008177 | molecular_function | succinate dehydrogenase (quinone) activity |
| M | 0009055 | molecular_function | electron transfer activity |
| M | 0009061 | biological_process | anaerobic respiration |
| M | 0016020 | cellular_component | membrane |
| M | 0016491 | molecular_function | oxidoreductase activity |
| M | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| M | 0019645 | biological_process | anaerobic electron transport chain |
| M | 0022900 | biological_process | electron transport chain |
| M | 0044780 | biological_process | bacterial-type flagellum assembly |
| M | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
| M | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| M | 0071949 | molecular_function | FAD binding |
| N | 0006099 | biological_process | tricarboxylic acid cycle |
| N | 0009055 | molecular_function | electron transfer activity |
| N | 0016491 | molecular_function | oxidoreductase activity |
| N | 0051536 | molecular_function | iron-sulfur cluster binding |
| N | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| O | 0016020 | cellular_component | membrane |
| P | 0000104 | molecular_function | succinate dehydrogenase activity |
| P | 0005886 | cellular_component | plasma membrane |
| P | 0006106 | biological_process | fumarate metabolic process |
| P | 0006113 | biological_process | fermentation |
| P | 0009061 | biological_process | anaerobic respiration |
| P | 0016020 | cellular_component | membrane |
| P | 0019645 | biological_process | anaerobic electron transport chain |
| P | 0044780 | biological_process | bacterial-type flagellum assembly |
| P | 0045284 | cellular_component | obsolete plasma membrane fumarate reductase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD A 601 |
| Chain | Residue |
| A | GLY11 |
| A | HIS44 |
| A | THR45 |
| A | ALA48 |
| A | GLY50 |
| A | GLY51 |
| A | HIS155 |
| A | VAL157 |
| A | ALA191 |
| A | THR192 |
| A | GLY193 |
| A | ALA12 |
| A | THR203 |
| A | ASP211 |
| A | LEU242 |
| A | HIS355 |
| A | TYR356 |
| A | GLY378 |
| A | GLU379 |
| A | ARG390 |
| A | SER393 |
| A | ASN394 |
| A | GLY13 |
| A | SER395 |
| A | LEU396 |
| A | LEU399 |
| A | GLY14 |
| A | ALA15 |
| A | SER36 |
| A | LYS37 |
| A | VAL38 |
| A | SER43 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FES B 301 |
| Chain | Residue |
| B | SER56 |
| B | CYS57 |
| B | ARG58 |
| B | CYS62 |
| B | GLY63 |
| B | CYS65 |
| B | CYS77 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F3S B 302 |
| Chain | Residue |
| B | CYS158 |
| B | GLN160 |
| B | CYS204 |
| B | THR205 |
| B | PHE206 |
| B | GLY208 |
| B | CYS210 |
| B | ALA221 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 B 303 |
| Chain | Residue |
| B | CYS148 |
| B | ILE149 |
| B | CYS151 |
| B | GLY152 |
| B | CYS154 |
| B | CYS214 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MQ7 D 701 |
| Chain | Residue |
| B | CYS204 |
| B | THR205 |
| B | PHE206 |
| B | GLN225 |
| B | LYS228 |
| C | ARG28 |
| D | GLU10 |
| D | TRP14 |
| D | PHE17 |
| D | GLY18 |
| D | HIS80 |
| D | HIS84 |
| site_id | AC6 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE FAD M 601 |
| Chain | Residue |
| M | GLY11 |
| M | ALA12 |
| M | GLY13 |
| M | GLY14 |
| M | ALA15 |
| M | SER36 |
| M | LYS37 |
| M | VAL38 |
| M | SER43 |
| M | HIS44 |
| M | THR45 |
| M | ALA48 |
| M | GLY50 |
| M | GLY51 |
| M | PHE156 |
| M | VAL157 |
| M | ALA191 |
| M | THR192 |
| M | GLY193 |
| M | THR203 |
| M | ASP211 |
| M | LEU242 |
| M | HIS355 |
| M | TYR356 |
| M | GLU379 |
| M | ARG390 |
| M | SER393 |
| M | ASN394 |
| M | SER395 |
| M | LEU396 |
| M | LEU399 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FES N 301 |
| Chain | Residue |
| N | CYS62 |
| N | GLY63 |
| N | SER64 |
| N | CYS65 |
| N | CYS77 |
| N | SER56 |
| N | CYS57 |
| N | ARG58 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F3S N 302 |
| Chain | Residue |
| N | CYS158 |
| N | GLN160 |
| N | CYS204 |
| N | THR205 |
| N | GLY208 |
| N | CYS210 |
| N | ALA221 |
| N | ILE224 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 N 303 |
| Chain | Residue |
| N | CYS148 |
| N | CYS151 |
| N | GLY152 |
| N | CYS154 |
| N | CYS214 |
| N | VAL218 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MQ7 N 304 |
| Chain | Residue |
| N | CYS204 |
| N | THR205 |
| N | GLN225 |
| N | LYS228 |
| O | ARG28 |
| P | TRP14 |
| P | HIS84 |
Functional Information from PROSITE/UniProt
| site_id | PS00197 |
| Number of Residues | 9 |
| Details | 2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CRMAICGSC |
| Chain | Residue | Details |
| B | CYS57-CYS65 |
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiNCGlCYaACP |
| Chain | Residue | Details |
| B | CYS148-PRO159 |
| site_id | PS00504 |
| Number of Residues | 10 |
| Details | FRD_SDH_FAD_BINDING Fumarate reductase / succinate dehydrogenase FAD-binding site. RSHTvaAeGG |
| Chain | Residue | Details |
| A | ARG42-GLY51 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10373108 |
| Chain | Residue | Details |
| D | MET0-ARG7 | |
| D | LEU89-ALA95 | |
| P | MET0-ARG7 | |
| P | LEU89-ALA95 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 144 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:10373108 |
| Chain | Residue | Details |
| D | SER8-LEU34 | |
| M | SER43 | |
| M | HIS155 | |
| M | ASP211 | |
| M | GLU379 | |
| M | ARG390 | |
| D | SER60-ASP88 | |
| D | GLY96-GLY114 | |
| P | SER8-LEU34 | |
| P | SER60-ASP88 | |
| P | GLY96-GLY114 | |
| A | ARG390 | |
| M | GLY11 | |
| M | ILE35 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:10373108 |
| Chain | Residue | Details |
| D | VAL35-GLN59 | |
| P | VAL35-GLN59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:10373108, ECO:0000269|PubMed:15919996 |
| Chain | Residue | Details |
| D | VAL115-ILE118 | |
| P | VAL115-ILE118 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1L0V |
| Chain | Residue | Details |
| D | TRP14 | |
| P | TRP14 |
