Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KVM

The NatA (Naa10p/Naa15p) amino-terminal acetyltransferase complex bound to a bisubstrate analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0010698	molecular_function	acetyltransferase activator activity
A	0031415	cellular_component	NatA complex
A	0051604	biological_process	protein maturation
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0010698	molecular_function	acetyltransferase activator activity
B	0031415	cellular_component	NatA complex
B	0051604	biological_process	protein maturation
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0010698	molecular_function	acetyltransferase activator activity
C	0031415	cellular_component	NatA complex
C	0051604	biological_process	protein maturation
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0010698	molecular_function	acetyltransferase activator activity
D	0031415	cellular_component	NatA complex
D	0051604	biological_process	protein maturation
E	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
E	0006474	biological_process	N-terminal protein amino acid acetylation
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0031415	cellular_component	NatA complex
F	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
F	0006474	biological_process	N-terminal protein amino acid acetylation
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0031415	cellular_component	NatA complex
G	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
G	0006474	biological_process	N-terminal protein amino acid acetylation
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0031415	cellular_component	NatA complex
H	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
H	0006474	biological_process	N-terminal protein amino acid acetylation
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0031415	cellular_component	NatA complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 801

Chain	Residue
E	LEU19

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 802

Chain	Residue
A	PHE535

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 803

Chain	Residue
A	ALA163
A	LYS201

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 805

Chain	Residue
A	LYS129

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 807

Chain	Residue
A	ARG159

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 808

Chain	Residue
A	LYS425

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 809

Chain	Residue
A	ARG539

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 810

Chain	Residue
A	LYS456
A	ARG422

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 811

Chain	Residue
A	LYS129

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 812

Chain	Residue
A	LYS237

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 813

Chain	Residue
A	TYR246
A	ARG291

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 814

Chain	Residue
A	ARG563

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 815

Chain	Residue
A	ARG221
A	ARG251

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 801

Chain	Residue
B	HIS439

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 802

Chain	Residue
B	SER150

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 804

Chain	Residue
F	LEU19

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 805

Chain	Residue
B	PHE535

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 807

Chain	Residue
B	ARG544

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 808

Chain	Residue
B	ASP590
B	LYS593

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 809

Chain	Residue
B	ASP524
B	LYS668

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 810

Chain	Residue
B	ARG460
B	CL814

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 811

Chain	Residue
B	ARG422
B	LYS456
B	CL812

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 812

Chain	Residue
B	CL811

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 813

Chain	Residue
B	LYS425
B	LEU430
B	ARG460

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 814

Chain	Residue
B	LYS425
B	CL810

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 815

Chain	Residue
B	LYS129
C	TYR721
C	LYS725
C	CL806

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 816

Chain	Residue
B	LYS129

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 801

Chain	Residue
C	ARG291

site_id	DC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 803

Chain	Residue
C	LYS24

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 804

Chain	Residue
C	LYS129

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 806

Chain	Residue
B	LYS129
B	CL815

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 807

Chain	Residue
C	ARG422
C	CL810

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 808

Chain	Residue
C	LYS425
C	HOH901

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 809

Chain	Residue
C	HIS426
C	HOH922

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 810

Chain	Residue
C	ARG422
C	LYS456
C	CL807

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 811

Chain	Residue
C	SER150

site_id	EC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 812

Chain	Residue
C	ARG448

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 813

Chain	Residue
C	GLN96

site_id	EC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 801

Chain	Residue
D	ARG539
D	HOH955

site_id	EC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 802

Chain	Residue
D	LYS606

site_id	EC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 803

Chain	Residue
D	CL811
D	CL813

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 804

Chain	Residue
D	ILE11
D	ARG15

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 805

Chain	Residue
D	ARG72
D	LEU323
D	LYS324
D	THR377
D	THR378

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 806

Chain	Residue
D	ARG126
D	TYR128
D	LYS129

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 807

Chain	Residue
D	ARG146
D	VAL182
D	GLU186

site_id	FC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 808

Chain	Residue
D	ARG159

site_id	FC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 809

Chain	Residue
D	LYS201

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 810

Chain	Residue
D	ARG72
D	LYS324

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 811

Chain	Residue
D	ARG422
D	LYS456
D	CL803

site_id	FC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 812

Chain	Residue
D	ARG539

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 813

Chain	Residue
D	LYS425
D	CL803

site_id	FC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 815

Chain	Residue
D	LEU511

site_id	FC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 816

Chain	Residue
D	ARG221
D	ARG251

site_id	FC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 201

Chain	Residue
G	ARG124
G	ASP125

site_id	GC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE 1XE I 5201

Chain	Residue
E	ARG83
E	HIS84
E	GLY86
E	LEU87
E	ALA88
E	LYS89
E	HIS111
E	VAL112
E	ASN116
E	ARG117
E	ALA118
E	ALA119
E	LEU122
E	TYR123
E	THR126
I	SER5122
I	HOH5301
A	GLU42
E	ASN21
E	LEU22
E	SER75
E	VAL76
E	SER77
E	VAL78

site_id	GC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1XE J 5201

Chain	Residue
F	ASN21
F	LEU22
F	SER75
F	VAL76
F	SER77
F	VAL78
F	ARG83
F	HIS84
F	GLY86
F	LEU87
F	ALA88
F	LYS89
F	HIS111
F	VAL112
F	ASN116
F	ARG117
F	ALA118
F	ALA119
F	LEU122
F	TYR123
J	SER5122

site_id	GC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1XE K 5201

Chain	Residue
G	LEU22
G	SER75
G	VAL76
G	SER77
G	VAL78
G	ARG83
G	HIS84
G	GLY86
G	LEU87
G	ALA88
G	LYS89
G	HIS111
G	VAL112
G	ASN116
G	LEU122
G	TYR123
G	THR126
K	SER5122

site_id	GC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 1XE L 5201

Chain	Residue
D	GLU42
H	ASN21
H	LEU22
H	SER75
H	VAL76
H	SER77
H	VAL78
H	ARG83
H	HIS84
H	GLY86
H	LEU87
H	ALA88
H	LYS89
H	HIS111
H	VAL112
H	ASN116
H	ALA118
H	ALA119
H	HIS121
H	LEU122
H	TYR123
L	SER5122

site_id	GC5
Number of Residues	8
Details	BINDING SITE FOR CHAIN I OF BISUBSTRATE ANALOG INHIBITOR

Chain	Residue
E	GLU24
E	TYR26
E	TYR30
E	THR74
E	HIS111
E	TYR138
E	TYR139
I	1XE5201

site_id	GC6
Number of Residues	9
Details	BINDING SITE FOR CHAIN J OF BISUBSTRATE ANALOG INHIBITOR

Chain	Residue
F	GLU24
F	TYR26
F	THR74
F	HIS111
F	TYR138
F	TYR139
F	HOH305
J	1XE5201
J	HOH5301

site_id	GC7
Number of Residues	7
Details	BINDING SITE FOR CHAIN K OF BISUBSTRATE ANALOG INHIBITOR

Chain	Residue
G	GLU24
G	TYR26
G	THR74
G	HIS111
G	TYR138
G	TYR139
K	1XE5201

site_id	GC8
Number of Residues	8
Details	BINDING SITE FOR CHAIN L OF BISUBSTRATE ANALOG INHIBITOR

Chain	Residue
H	GLU24
H	TYR26
H	THR74
H	HIS111
H	TYR138
H	TYR139
L	1XE5201
L	HOH5301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	128
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	132
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	144
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	132
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	132
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	128
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	132
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	132
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	608
Details	Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)