4KVK

Crystal structure of Oryza sativa fatty acid alpha-dioxygenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001561	biological_process	fatty acid alpha-oxidation
A	0001676	biological_process	long-chain fatty acid metabolic process
A	0004601	molecular_function	peroxidase activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006952	biological_process	defense response
A	0006979	biological_process	response to oxidative stress
A	0009627	biological_process	systemic acquired resistance
A	0009737	biological_process	response to abscisic acid
A	0009751	biological_process	response to salicylic acid
A	0012511	cellular_component	monolayer-surrounded lipid storage body
A	0016491	molecular_function	oxidoreductase activity
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0020037	molecular_function	heme binding
A	0031408	biological_process	oxylipin biosynthetic process
A	0034614	biological_process	cellular response to reactive oxygen species
A	0042742	biological_process	defense response to bacterium
A	0046872	molecular_function	metal ion binding
A	0050832	biological_process	defense response to fungus
A	0051213	molecular_function	dioxygenase activity
A	0071446	biological_process	cellular response to salicylic acid stimulus
A	0071732	biological_process	cellular response to nitric oxide
A	0098869	biological_process	cellular oxidant detoxification
A	1902609	biological_process	(R)-2-hydroxy-alpha-linolenic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM A 701

Chain	Residue
A	ALA149
A	THR376
A	TYR379
A	MET381
A	HIS382
A	ILE416
A	PHE453
A	LEU472
A	LEU475
A	ARG479
A	ARG483
A	ILE152
A	HOH815
A	HOH843
A	HOH996
A	HOH1180
A	GLN153
A	VAL156
A	HIS157
A	ASP161
A	HIS162
A	ASN260
A	TRP262

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DMU A 702

Chain	Residue
A	SER19
A	LYS20
A	MET21
A	SER22
A	PHE23
A	LYS26
A	PHE31
A	ARG38
A	ILE348
A	PG4709
A	HOH829
A	HOH928
A	HOH1055

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PG4 A 703

Chain	Residue
A	ASN54
A	ARG57

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG A 704

Chain	Residue
A	PHE24

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 1PE A 705

Chain	Residue
A	ASN39
A	HIS42
A	LYS43
A	ARG492
A	ILE498
A	PRO499
A	ILE500
A	ASP505
A	GLU536
A	NA717
A	HOH832
A	HOH1029
A	HOH1117

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE A 706

Chain	Residue
A	GLU490
A	ARG493
A	ARG494
A	PHE496

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 A 707

Chain	Residue
A	ARG590
A	LYS606
A	SER608
A	TYR618
A	NA718

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 708

Chain	Residue
A	ILE239
A	GLY240
A	ASP241
A	GLY243
A	LYS274

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 A 709

Chain	Residue
A	ALA34
A	PHE35
A	ARG38
A	DMU702
A	HOH1119

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 710

Chain	Residue
A	LYS323
A	ARG326
A	HOH1023
A	HOH1028

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG A 711

Chain	Residue
A	ARG517
A	ALA518
A	ILE519

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 712

Chain	Residue
A	THR210
A	TRP212
A	ASP214
A	SER216
A	HOH874
A	HOH1085

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 713

Chain	Residue
A	LYS309
A	TRP333
A	HOH1132

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 714

Chain	Residue
A	ARG330
A	LYS339
A	HOH954

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 715

Chain	Residue
A	GLY350
A	ILE352
A	LEU353
A	HOH922

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 716

Chain	Residue
A	HIS311
A	TYR379

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 717

Chain	Residue
A	HOH981
A	HOH1117
A	ASP505
A	1PE705
A	HOH980

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 718

Chain	Residue
A	SER608
A	PG4707
A	HOH1228

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00298","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23934749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00298","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23934749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU00298","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---