Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003810 | molecular_function | protein-glutamine gamma-glutamyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005737 | cellular_component | cytoplasm |
A | 0007596 | biological_process | blood coagulation |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0018149 | biological_process | peptide cross-linking |
A | 0031093 | cellular_component | platelet alpha granule lumen |
A | 0046872 | molecular_function | metal ion binding |
A | 0062023 | cellular_component | collagen-containing extracellular matrix |
A | 0072378 | biological_process | blood coagulation, fibrin clot formation |
A | 0072562 | cellular_component | blood microparticle |
A | 1990234 | cellular_component | transferase complex |
B | 0003810 | molecular_function | protein-glutamine gamma-glutamyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005737 | cellular_component | cytoplasm |
B | 0007596 | biological_process | blood coagulation |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0018149 | biological_process | peptide cross-linking |
B | 0031093 | cellular_component | platelet alpha granule lumen |
B | 0046872 | molecular_function | metal ion binding |
B | 0062023 | cellular_component | collagen-containing extracellular matrix |
B | 0072378 | biological_process | blood coagulation, fibrin clot formation |
B | 0072562 | cellular_component | blood microparticle |
B | 1990234 | cellular_component | transferase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DAS C 2 |
Chain | Residue |
A | TYR214 |
A | ARG223 |
A | GLN313 |
A | ASN371 |
A | TYR372 |
C | ACY1 |
C | 1TX3 |
C | ABA4 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE DAS D 2 |
Chain | Residue |
B | ARG223 |
B | GLN313 |
B | ASN371 |
B | TYR372 |
D | ACY1 |
D | 1TX3 |
D | ABA4 |
D | HOH107 |
B | TYR214 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 801 |
Chain | Residue |
A | ALA264 |
A | ASN267 |
A | LYS269 |
A | ASP271 |
A | HOH906 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 802 |
Chain | Residue |
A | ASP343 |
A | ASP345 |
A | ASN347 |
A | GLN349 |
A | ASP351 |
A | ASP367 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 803 |
Chain | Residue |
A | ASN436 |
A | ALA457 |
A | GLU485 |
A | GLU490 |
A | HOH908 |
A | HOH909 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 804 |
Chain | Residue |
A | TYR194 |
A | LEU195 |
A | ASP196 |
A | TRP379 |
A | PHE559 |
A | THR561 |
A | HOH929 |
A | HOH1269 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 805 |
Chain | Residue |
A | PHE53 |
A | ASP58 |
A | THR59 |
A | TYR83 |
A | HOH974 |
A | HOH1151 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 806 |
Chain | Residue |
A | VAL287 |
A | GLU301 |
A | VAL309 |
A | ARG310 |
A | HOH1174 |
site_id | AC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 807 |
Chain | Residue |
A | ASN20 |
A | GLU23 |
A | LYS156 |
A | ARG158 |
A | ARG174 |
A | ASP179 |
A | HOH979 |
A | HOH1100 |
A | HOH1326 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 808 |
Chain | Residue |
A | ARG715 |
A | HIS716 |
A | HOH1048 |
A | HOH1303 |
B | TRP164 |
B | THR165 |
B | GLY168 |
B | VAL169 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 809 |
Chain | Residue |
A | ASN541 |
A | ASN542 |
A | LEU580 |
A | SER581 |
B | VAL39 |
B | HOH1343 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 801 |
Chain | Residue |
B | ALA264 |
B | ASN267 |
B | LYS269 |
B | ASP271 |
B | HOH901 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 802 |
Chain | Residue |
B | ASP343 |
B | ASP345 |
B | ASN347 |
B | GLN349 |
B | ASP351 |
B | ASP367 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 803 |
Chain | Residue |
B | ASN436 |
B | ALA457 |
B | GLU485 |
B | GLU490 |
B | HOH973 |
B | HOH1307 |
site_id | BC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 804 |
Chain | Residue |
B | HOH914 |
B | HOH1104 |
B | HOH1212 |
B | TYR194 |
B | LEU195 |
B | ASP196 |
B | TRP379 |
B | PHE559 |
B | THR561 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 805 |
Chain | Residue |
B | PHE53 |
B | ASP58 |
B | THR59 |
B | TYR83 |
B | ARG143 |
B | HOH985 |
B | HOH1178 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 806 |
Chain | Residue |
A | HOH1285 |
B | ARG100 |
B | TRP164 |
B | HOH933 |
B | HOH1306 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 807 |
Chain | Residue |
B | LYS269 |
B | ASP270 |
B | ARG681 |
B | HOH1131 |
B | HOH1293 |
B | HOH1304 |
Functional Information from PROSITE/UniProt
site_id | PS00547 |
Number of Residues | 18 |
Details | TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAGVfnTfLRCLG |
Chain | Residue | Details |
A | GLY312-GLY329 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | CYS314 | |
A | HIS373 | |
A | ASP396 | |
B | CYS314 | |
B | HIS373 | |
B | ASP396 | |
Chain | Residue | Details |
A | ASN436 | |
A | ASP438 | |
A | GLU485 | |
A | GLU490 | |
B | ASN436 | |
B | ASP438 | |
B | GLU485 | |
B | GLU490 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Cleavage; by thrombin; to produce active factor XIII-A |
Chain | Residue | Details |
A | ARG37 | |
B | ARG37 | |
Chain | Residue | Details |
A | SER1 | |
B | SER1 | |
Chain | Residue | Details |
A | ASN613 | |
B | ASN613 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 149 |
Chain | Residue | Details |
A | TRP279 | electrostatic stabiliser, hydrogen bond donor |
A | CYS314 | electrostatic stabiliser |
A | HIS373 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | ASP396 | electrostatic stabiliser, hydrogen bond acceptor |
A | TYR560 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 149 |
Chain | Residue | Details |
B | TRP279 | electrostatic stabiliser, hydrogen bond donor |
B | CYS314 | electrostatic stabiliser |
B | HIS373 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | ASP396 | electrostatic stabiliser, hydrogen bond acceptor |
B | TYR560 | electrostatic stabiliser, hydrogen bond donor |