4KSL

Gumby/Fam105B in complex with linear di-ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	1990108	biological_process	protein linear deubiquitination
E	0004843	molecular_function	cysteine-type deubiquitinase activity
E	1990108	biological_process	protein linear deubiquitination
G	0004843	molecular_function	cysteine-type deubiquitinase activity
G	1990108	biological_process	protein linear deubiquitination
I	0004843	molecular_function	cysteine-type deubiquitinase activity
I	1990108	biological_process	protein linear deubiquitination
K	0004843	molecular_function	cysteine-type deubiquitinase activity
K	1990108	biological_process	protein linear deubiquitination
M	0004843	molecular_function	cysteine-type deubiquitinase activity
M	1990108	biological_process	protein linear deubiquitination
O	0004843	molecular_function	cysteine-type deubiquitinase activity
O	1990108	biological_process	protein linear deubiquitination
Q	0004843	molecular_function	cysteine-type deubiquitinase activity
Q	1990108	biological_process	protein linear deubiquitination
S	0004843	molecular_function	cysteine-type deubiquitinase activity
S	1990108	biological_process	protein linear deubiquitination
U	0004843	molecular_function	cysteine-type deubiquitinase activity
U	1990108	biological_process	protein linear deubiquitination
W	0004843	molecular_function	cysteine-type deubiquitinase activity
W	1990108	biological_process	protein linear deubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
D	LYS27-ASP52
D	LYS1027-ASP1052

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
D	GLY0
T	GLY0
V	GLY0
X	GLY0
M	ASP126
M	HIS339
O	ASP126
O	HIS339
Q	ASP126
Q	HIS339
S	ASP126
C	GLY0
S	HIS339
U	ASP126
U	HIS339
W	ASP126
W	HIS339
F	GLY0
H	GLY0
J	GLY0
L	GLY0
N	GLY0
P	GLY0
R	GLY0

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site_id	SWS_FT_FI2
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
D	GLY0
S	ALA129
L	GLY0
W	ALA129
N	GLY0
P	GLY0
R	GLY0
T	GLY0
B	ALA129
V	GLY0
X	GLY0
C	GLY0
G	ALA129
F	GLY0
K	ALA129
H	GLY0
O	ALA129
J	GLY0

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site_id	SWS_FT_FI3
Number of Residues	12
Details	SITE: Linear diubiquitin binding => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSK, ECO:0007744|PDB:4KSL

Chain	Residue	Details
A	GLU314
S	GLU314
U	GLU314
W	GLU314
B	GLU314
E	GLU314
G	GLU314
I	GLU314
K	GLU314
M	GLU314
O	GLU314
Q	GLU314

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