4KSL
Gumby/Fam105B in complex with linear di-ubiquitin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 1990108 | biological_process | protein linear deubiquitination |
| B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| B | 1990108 | biological_process | protein linear deubiquitination |
| E | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| E | 1990108 | biological_process | protein linear deubiquitination |
| G | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| G | 1990108 | biological_process | protein linear deubiquitination |
| I | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| I | 1990108 | biological_process | protein linear deubiquitination |
| K | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| K | 1990108 | biological_process | protein linear deubiquitination |
| M | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| M | 1990108 | biological_process | protein linear deubiquitination |
| O | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| O | 1990108 | biological_process | protein linear deubiquitination |
| Q | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| Q | 1990108 | biological_process | protein linear deubiquitination |
| S | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| S | 1990108 | biological_process | protein linear deubiquitination |
| U | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| U | 1990108 | biological_process | protein linear deubiquitination |
| W | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| W | 1990108 | biological_process | protein linear deubiquitination |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| D | LYS27-ASP52 | |
| D | LYS1027-ASP1052 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 120 |
| Details | Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24726327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Site: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 456 |
| Details | Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 900 |
| Details | Domain: {"description":"Ubiquitin-like 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
