4KIK

Human IkB kinase beta

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE KSA A 800

Chain	Residue
A	LEU21
A	GLY102
A	GLU149
A	ILE165
A	GLY22
A	THR23
A	VAL29
A	ALA42
A	MET96
A	GLU97
A	TYR98
A	CYS99

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE KSA B 700

Chain	Residue
B	LEU21
B	GLY22
B	VAL29
B	ALA42
B	LYS44
B	MET96
B	GLU97
B	TYR98
B	CYS99
B	GLY102
B	GLU149
B	ASN150
B	ILE165
B	ASP166

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNIVL

Chain	Residue	Details
B	ILE141-LEU153
A	ILE141-LEU153

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-acetylthreonine; by Yersinia YopJ","evidences":[{"source":"PubMed","id":"17116858","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by TBK1, PKC/PRKCZ and PDPK1","evidences":[{"source":"PubMed","id":"10022904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10195894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10783893","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16207722","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Hydroxyproline","evidences":[{"source":"PubMed","id":"17114296","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"16267042","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by TBK1 and PKC/PRKCZ","evidences":[{"source":"PubMed","id":"10022904","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10195894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10783893","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"15184672","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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