4KIK

Human IkB kinase beta

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE KSA A 800

Chain	Residue
A	LEU21
A	GLY102
A	GLU149
A	ILE165
A	GLY22
A	THR23
A	VAL29
A	ALA42
A	MET96
A	GLU97
A	TYR98
A	CYS99

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE KSA B 700

Chain	Residue
B	LEU21
B	GLY22
B	VAL29
B	ALA42
B	LYS44
B	MET96
B	GLU97
B	TYR98
B	CYS99
B	GLY102
B	GLU149
B	ASN150
B	ILE165
B	ASP166

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpeNIVL

Chain	Residue	Details
A	ILE141-LEU153
B	ILE141-LEU153

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
B	ASP145

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
B	LYS44
B	LEU21

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by TBK1 and PKC/PRKCZ => ECO:0000269|PubMed:10022904, ECO:0000269|PubMed:10195894, ECO:0000269|PubMed:10783893

Chain	Residue	Details
B	SEP177

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:15184672

Chain	Residue	Details
B	CYS179

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:17116858

Chain	Residue	Details
B	THR180

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by TBK1, PKC/PRKCZ and PDPK1 => ECO:0000269|PubMed:10022904, ECO:0000269|PubMed:10195894, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:16207722

Chain	Residue	Details
B	SEP181

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Hydroxyproline => ECO:0000269|PubMed:17114296

Chain	Residue	Details
B	PRO191

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16267042

Chain	Residue	Details
B	LYS163

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