4KIC

Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with S-adenosyl-L-methionine and phenylpyruvic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0017000	biological_process	antibiotic biosynthetic process
A	0032259	biological_process	methylation
B	0008168	molecular_function	methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0017000	biological_process	antibiotic biosynthetic process
B	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE SAM A 401

Chain	Residue
A	CYS136
A	ALA218
A	ARG219
A	PHE239
A	MET240
A	MET241
A	ASP244
A	PPY402
A	HOH521
A	HOH522
A	HOH525
A	GLY166
A	HOH538
A	HOH544
A	HOH562
A	HOH575
A	GLY168
A	ARG172
A	ASP189
A	ILE190
A	ALA191
A	GLY216
A	ASP217

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PPY A 402

Chain	Residue
A	TRP99
A	ARG127
A	MET240
A	HIS243
A	ASP272
A	ALA273
A	PHE287
A	PHE291
A	HIS295
A	SAM401
A	FE403
A	HOH501
A	HOH502

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 403

Chain	Residue
A	HIS243
A	HIS295
A	PPY402
A	HOH501
A	HOH502

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE HF2 A 404

Chain	Residue
A	ASP309
A	PHE312
A	CYS319
A	LYS322
A	PHE334
B	LYS322
B	ALA324

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 405

Chain	Residue
A	ARG12

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 406

Chain	Residue
A	ARG75

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 407

Chain	Residue
A	GLU106
A	ARG127
A	HOH651
B	ARG109

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 408

Chain	Residue
A	ARG109
B	ARG127

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA A 409

Chain	Residue
A	ASP217
A	HOH644

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 410

Chain	Residue
A	GLN113

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 411

Chain	Residue
A	LYS123

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 412

Chain	Residue
A	LYS44

---

site_id	BC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAM B 401

Chain	Residue
B	CYS136
B	GLY166
B	ARG172
B	ASP189
B	ILE190
B	ALA191
B	GLY216
B	ASP217
B	ALA218
B	ARG219
B	PHE239
B	MET240
B	MET241
B	ASP244
B	PPY402
B	HOH513
B	HOH522
B	HOH524
B	HOH538
B	HOH560
B	HOH589
B	HOH612

---

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PPY B 402

Chain	Residue
B	TRP99
B	ARG127
B	MET240
B	HIS243
B	ALA273
B	PHE287
B	PHE291
B	HIS295
B	SAM401
B	FE403
B	HOH501
B	HOH502

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE B 403

Chain	Residue
B	HOH502
B	HIS243
B	HIS295
B	PPY402
B	HOH501

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HF2 B 404

Chain	Residue
A	LYS322
A	ALA324
B	ASP309
B	CYS319
B	LYS322
B	PHE334

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 405

Chain	Residue
B	ARG75

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 406

Chain	Residue
B	ARG12

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 408

Chain	Residue
B	GLN113

---

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA B 409

Chain	Residue
B	ASP217

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 410

Chain	Residue
B	THR220
B	ASP222
B	GLN223

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