Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4KBR

Crystal structure of mouse Ceramide-1-phosphate transfer protein (apo-form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005543	molecular_function	phospholipid binding
A	0005634	cellular_component	nucleus
A	0005640	cellular_component	nuclear outer membrane
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0010008	cellular_component	endosome membrane
A	0010507	biological_process	negative regulation of autophagy
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0035627	biological_process	ceramide transport
A	0120009	biological_process	intermembrane lipid transfer
A	0120013	molecular_function	lipid transfer activity
A	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
A	1902387	molecular_function	ceramide 1-phosphate binding
A	1902388	molecular_function	ceramide 1-phosphate transfer activity
A	1902389	biological_process	ceramide 1-phosphate transport
B	0005543	molecular_function	phospholipid binding
B	0005634	cellular_component	nucleus
B	0005640	cellular_component	nuclear outer membrane
B	0005737	cellular_component	cytoplasm
B	0005768	cellular_component	endosome
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0010008	cellular_component	endosome membrane
B	0010507	biological_process	negative regulation of autophagy
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0035627	biological_process	ceramide transport
B	0120009	biological_process	intermembrane lipid transfer
B	0120013	molecular_function	lipid transfer activity
B	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
B	1902387	molecular_function	ceramide 1-phosphate binding
B	1902388	molecular_function	ceramide 1-phosphate transfer activity
B	1902389	biological_process	ceramide 1-phosphate transport
C	0005543	molecular_function	phospholipid binding
C	0005634	cellular_component	nucleus
C	0005640	cellular_component	nuclear outer membrane
C	0005737	cellular_component	cytoplasm
C	0005768	cellular_component	endosome
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0010008	cellular_component	endosome membrane
C	0010507	biological_process	negative regulation of autophagy
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0035627	biological_process	ceramide transport
C	0120009	biological_process	intermembrane lipid transfer
C	0120013	molecular_function	lipid transfer activity
C	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
C	1902387	molecular_function	ceramide 1-phosphate binding
C	1902388	molecular_function	ceramide 1-phosphate transfer activity
C	1902389	biological_process	ceramide 1-phosphate transport
D	0005543	molecular_function	phospholipid binding
D	0005634	cellular_component	nucleus
D	0005640	cellular_component	nuclear outer membrane
D	0005737	cellular_component	cytoplasm
D	0005768	cellular_component	endosome
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0010008	cellular_component	endosome membrane
D	0010507	biological_process	negative regulation of autophagy
D	0032691	biological_process	negative regulation of interleukin-1 beta production
D	0035627	biological_process	ceramide transport
D	0120009	biological_process	intermembrane lipid transfer
D	0120013	molecular_function	lipid transfer activity
D	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
D	1902387	molecular_function	ceramide 1-phosphate binding
D	1902388	molecular_function	ceramide 1-phosphate transfer activity
D	1902389	biological_process	ceramide 1-phosphate transport
E	0005543	molecular_function	phospholipid binding
E	0005634	cellular_component	nucleus
E	0005640	cellular_component	nuclear outer membrane
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006869	biological_process	lipid transport
E	0008289	molecular_function	lipid binding
E	0010008	cellular_component	endosome membrane
E	0010507	biological_process	negative regulation of autophagy
E	0032691	biological_process	negative regulation of interleukin-1 beta production
E	0035627	biological_process	ceramide transport
E	0120009	biological_process	intermembrane lipid transfer
E	0120013	molecular_function	lipid transfer activity
E	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
E	1902387	molecular_function	ceramide 1-phosphate binding
E	1902388	molecular_function	ceramide 1-phosphate transfer activity
E	1902389	biological_process	ceramide 1-phosphate transport
F	0005543	molecular_function	phospholipid binding
F	0005634	cellular_component	nucleus
F	0005640	cellular_component	nuclear outer membrane
F	0005737	cellular_component	cytoplasm
F	0005768	cellular_component	endosome
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0010008	cellular_component	endosome membrane
F	0010507	biological_process	negative regulation of autophagy
F	0032691	biological_process	negative regulation of interleukin-1 beta production
F	0035627	biological_process	ceramide transport
F	0120009	biological_process	intermembrane lipid transfer
F	0120013	molecular_function	lipid transfer activity
F	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
F	1902387	molecular_function	ceramide 1-phosphate binding
F	1902388	molecular_function	ceramide 1-phosphate transfer activity
F	1902389	biological_process	ceramide 1-phosphate transport
G	0005543	molecular_function	phospholipid binding
G	0005634	cellular_component	nucleus
G	0005640	cellular_component	nuclear outer membrane
G	0005737	cellular_component	cytoplasm
G	0005768	cellular_component	endosome
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006869	biological_process	lipid transport
G	0008289	molecular_function	lipid binding
G	0010008	cellular_component	endosome membrane
G	0010507	biological_process	negative regulation of autophagy
G	0032691	biological_process	negative regulation of interleukin-1 beta production
G	0035627	biological_process	ceramide transport
G	0120009	biological_process	intermembrane lipid transfer
G	0120013	molecular_function	lipid transfer activity
G	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
G	1902387	molecular_function	ceramide 1-phosphate binding
G	1902388	molecular_function	ceramide 1-phosphate transfer activity
G	1902389	biological_process	ceramide 1-phosphate transport
H	0005543	molecular_function	phospholipid binding
H	0005634	cellular_component	nucleus
H	0005640	cellular_component	nuclear outer membrane
H	0005737	cellular_component	cytoplasm
H	0005768	cellular_component	endosome
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006869	biological_process	lipid transport
H	0008289	molecular_function	lipid binding
H	0010008	cellular_component	endosome membrane
H	0010507	biological_process	negative regulation of autophagy
H	0032691	biological_process	negative regulation of interleukin-1 beta production
H	0035627	biological_process	ceramide transport
H	0120009	biological_process	intermembrane lipid transfer
H	0120013	molecular_function	lipid transfer activity
H	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
H	1902387	molecular_function	ceramide 1-phosphate binding
H	1902388	molecular_function	ceramide 1-phosphate transfer activity
H	1902389	biological_process	ceramide 1-phosphate transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 301

Chain	Residue
A	LYS60
A	ARG108

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 B 301

Chain	Residue
B	LYS60
B	ARG108
B	ARG112

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 301

Chain	Residue
C	LYS60
C	ARG108
C	ARG112

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 D 301

Chain	Residue
D	ARG108
D	ARG112
D	LYS60

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 E 301

Chain	Residue
E	ARG108
E	ARG112

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 F 301

Chain	Residue
F	LYS60
F	ARG108
F	ARG112

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 G 301

Chain	Residue
G	LYS60
G	ARG108
G	ARG112

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 H 301

Chain	Residue
H	LYS60
H	ARG108
H	ARG112

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q5TA50

Chain	Residue	Details
A	ASP56
B	HIS152
C	ASP56
C	LYS60
C	ARG108
C	ARG112
C	HIS152
D	ASP56
D	LYS60
D	ARG108
D	ARG112
A	LYS60
D	HIS152
E	ASP56
E	LYS60
E	ARG108
E	ARG112
E	HIS152
F	ASP56
F	LYS60
F	ARG108
F	ARG112
A	ARG108
F	HIS152
G	ASP56
G	LYS60
G	ARG108
G	ARG112
G	HIS152
H	ASP56
H	LYS60
H	ARG108
H	ARG112
A	ARG112
H	HIS152
A	HIS152
B	ASP56
B	LYS60
B	ARG108
B	ARG112

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)