4K6O
X-ray structure uridine phosphorylase from Vibrio cholerae in complex with 6-methyluracil at 1.17 A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004850 | molecular_function | uridine phosphorylase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0009166 | biological_process | nucleotide catabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0044206 | biological_process | UMP salvage |
A | 0046872 | molecular_function | metal ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004850 | molecular_function | uridine phosphorylase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009164 | biological_process | nucleoside catabolic process |
B | 0009166 | biological_process | nucleotide catabolic process |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0044206 | biological_process | UMP salvage |
B | 0046872 | molecular_function | metal ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004850 | molecular_function | uridine phosphorylase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009164 | biological_process | nucleoside catabolic process |
C | 0009166 | biological_process | nucleotide catabolic process |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0044206 | biological_process | UMP salvage |
C | 0046872 | molecular_function | metal ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004850 | molecular_function | uridine phosphorylase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0009116 | biological_process | nucleoside metabolic process |
D | 0009164 | biological_process | nucleoside catabolic process |
D | 0009166 | biological_process | nucleotide catabolic process |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0016763 | molecular_function | pentosyltransferase activity |
D | 0044206 | biological_process | UMP salvage |
D | 0046872 | molecular_function | metal ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0004850 | molecular_function | uridine phosphorylase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0009116 | biological_process | nucleoside metabolic process |
E | 0009164 | biological_process | nucleoside catabolic process |
E | 0009166 | biological_process | nucleotide catabolic process |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0016763 | molecular_function | pentosyltransferase activity |
E | 0044206 | biological_process | UMP salvage |
E | 0046872 | molecular_function | metal ion binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0004850 | molecular_function | uridine phosphorylase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0009116 | biological_process | nucleoside metabolic process |
F | 0009164 | biological_process | nucleoside catabolic process |
F | 0009166 | biological_process | nucleotide catabolic process |
F | 0016757 | molecular_function | glycosyltransferase activity |
F | 0016763 | molecular_function | pentosyltransferase activity |
F | 0044206 | biological_process | UMP salvage |
F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 301 |
Chain | Residue |
A | ALA44 |
A | SER45 |
A | HOH572 |
A | HOH665 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 302 |
Chain | Residue |
A | GLY25 |
A | ASP26 |
A | HOH478 |
A | HOH491 |
B | HOH531 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 6MU A 303 |
Chain | Residue |
A | THR93 |
A | GLY95 |
A | PHE161 |
A | GLN165 |
A | ARG167 |
A | GLU195 |
A | MET196 |
A | ILE219 |
A | HOH463 |
A | HOH512 |
A | HOH530 |
A | HOH562 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 304 |
Chain | Residue |
A | GLN180 |
A | HOH496 |
A | HOH499 |
A | HOH535 |
A | HOH543 |
A | HOH600 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 305 |
Chain | Residue |
A | HOH457 |
A | HOH461 |
A | HOH474 |
A | HOH493 |
A | HOH519 |
A | HOH546 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 306 |
Chain | Residue |
A | GLU48 |
A | ILE68 |
A | SER72 |
B | GLU48 |
B | ILE68 |
B | SER72 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 307 |
Chain | Residue |
A | MET125 |
A | GLU126 |
A | HOH487 |
F | MET125 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EOH A 308 |
Chain | Residue |
A | ARG178 |
A | HOH584 |
A | HOH611 |
B | LEU120 |
B | HOH431 |
B | HOH435 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 309 |
Chain | Residue |
A | PHE133 |
A | HOH519 |
A | HOH602 |
F | THR110 |
F | HOH440 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL B 301 |
Chain | Residue |
B | GLY25 |
B | ASP26 |
B | HOH543 |
B | HOH646 |
B | HOH733 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 302 |
Chain | Residue |
B | ASN221 |
B | HOH593 |
site_id | BC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 6MU B 303 |
Chain | Residue |
B | THR93 |
B | GLY95 |
B | PHE161 |
B | GLN165 |
B | ARG167 |
B | GLU195 |
B | MET196 |
B | ILE219 |
B | ILE220 |
B | TRS308 |
B | HOH417 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 304 |
Chain | Residue |
B | GLN180 |
B | HOH471 |
B | HOH500 |
B | HOH510 |
B | HOH563 |
B | HOH598 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 305 |
Chain | Residue |
B | HOH444 |
B | HOH446 |
B | HOH506 |
B | HOH518 |
B | HOH727 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG B 306 |
Chain | Residue |
B | HOH456 |
B | HOH463 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA B 307 |
Chain | Residue |
B | ARG167 |
B | THR170 |
B | ARG174 |
B | HOH404 |
site_id | BC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TRS B 308 |
Chain | Residue |
B | HOH576 |
B | HOH698 |
A | HIS7 |
A | ARG47 |
B | ILE68 |
B | THR93 |
B | GLU195 |
B | MET196 |
B | GLU197 |
B | 6MU303 |
B | HOH402 |
B | HOH521 |
site_id | BC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 309 |
Chain | Residue |
B | PRO99 |
B | VAL101 |
B | ASN102 |
B | VAL103 |
B | ASN221 |
B | HOH593 |
B | HOH622 |
B | HOH629 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EOH B 310 |
Chain | Residue |
A | LEU120 |
A | HOH431 |
B | ARG178 |
B | HOH428 |
B | HOH618 |
C | HOH647 |
site_id | CC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 301 |
Chain | Residue |
C | GLY25 |
C | ASP26 |
C | HOH786 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 302 |
Chain | Residue |
C | ASN221 |
C | HOH594 |
site_id | CC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL C 303 |
Chain | Residue |
B | THR110 |
B | HOH493 |
C | PHE133 |
C | HOH446 |
C | HOH682 |
site_id | CC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 6MU C 304 |
Chain | Residue |
C | THR93 |
C | GLY95 |
C | PHE161 |
C | GLN165 |
C | ARG167 |
C | GLU195 |
C | MET196 |
C | ILE220 |
C | TRS309 |
C | HOH403 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 305 |
Chain | Residue |
C | GLN180 |
C | HOH525 |
C | HOH579 |
C | HOH591 |
C | HOH601 |
E | HOH543 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 306 |
Chain | Residue |
C | HOH603 |
C | HOH624 |
C | HOH692 |
C | HOH754 |
C | HOH758 |
C | HOH789 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 307 |
Chain | Residue |
B | HOH493 |
B | HOH527 |
C | HOH439 |
C | HOH444 |
C | HOH450 |
C | HOH533 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA C 308 |
Chain | Residue |
C | GLU48 |
C | ILE68 |
C | SER72 |
D | GLU48 |
D | ILE68 |
D | SER72 |
site_id | DC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TRS C 309 |
Chain | Residue |
C | ILE68 |
C | THR93 |
C | GLU195 |
C | MET196 |
C | GLU197 |
C | 6MU304 |
C | HOH472 |
C | HOH520 |
C | HOH731 |
D | HIS7 |
D | ARG47 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EOH C 310 |
Chain | Residue |
C | VAL101 |
C | ASN102 |
C | VAL103 |
C | ASN221 |
C | HOH594 |
C | HOH649 |
C | HOH705 |
site_id | DC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EOH C 311 |
Chain | Residue |
B | HOH631 |
C | ARG178 |
C | HOH630 |
C | HOH635 |
D | LEU120 |
D | HOH418 |
D | HOH427 |
site_id | DC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL C 312 |
Chain | Residue |
C | ARG47 |
C | HOH477 |
C | HOH704 |
D | GLY25 |
D | ILE68 |
D | ARG90 |
D | MET196 |
D | GLU197 |
D | HOH670 |
D | HOH821 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL D 301 |
Chain | Residue |
C | HOH523 |
D | GLY25 |
D | ASP26 |
D | HOH559 |
site_id | DC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 6MU D 302 |
Chain | Residue |
D | THR93 |
D | GLY95 |
D | GLN165 |
D | ARG167 |
D | GLU195 |
D | MET196 |
D | HOH445 |
D | HOH810 |
site_id | DC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 303 |
Chain | Residue |
D | GLN180 |
D | HOH464 |
D | HOH498 |
D | HOH499 |
D | HOH544 |
D | HOH631 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 304 |
Chain | Residue |
D | HIS46 |
D | HOH518 |
D | HOH652 |
D | HOH797 |
D | HOH814 |
site_id | DC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 305 |
Chain | Residue |
D | HOH439 |
D | HOH442 |
D | HOH480 |
D | HOH755 |
D | HOH757 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO D 306 |
Chain | Residue |
D | MET125 |
D | GLU126 |
D | HOH534 |
E | MET125 |
E | GLU126 |
site_id | EC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EOH D 307 |
Chain | Residue |
C | LEU120 |
C | HOH427 |
C | HOH428 |
D | ARG178 |
D | HOH560 |
D | HOH562 |
D | HOH778 |
site_id | EC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL E 301 |
Chain | Residue |
E | GLY25 |
E | ASP26 |
E | ARG29 |
F | HOH601 |
site_id | EC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 6MU E 302 |
Chain | Residue |
E | THR93 |
E | GLY95 |
E | PHE161 |
E | GLN165 |
E | ARG167 |
E | PHE194 |
E | GLU195 |
E | MET196 |
E | ILE220 |
E | TRS306 |
E | HOH420 |
site_id | EC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG E 303 |
Chain | Residue |
A | HOH795 |
E | GLN180 |
E | HOH654 |
E | HOH681 |
E | HOH728 |
site_id | EC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA E 304 |
Chain | Residue |
E | GLU48 |
E | ILE68 |
E | SER72 |
F | GLU48 |
F | ILE68 |
F | SER72 |
site_id | EC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TRS E 305 |
Chain | Residue |
E | HIS7 |
E | ARG47 |
E | HOH486 |
E | HOH526 |
E | HOH799 |
F | ILE68 |
F | THR93 |
F | GLU197 |
F | 6MU303 |
F | HOH831 |
site_id | EC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE TRS E 306 |
Chain | Residue |
E | ILE68 |
E | THR93 |
E | GLU195 |
E | MET196 |
E | GLU197 |
E | 6MU302 |
E | HOH457 |
E | HOH520 |
E | HOH702 |
E | HOH724 |
F | HIS7 |
F | ARG47 |
site_id | EC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EOH E 307 |
Chain | Residue |
D | HOH595 |
E | ARG178 |
E | HOH602 |
F | LEU120 |
F | HOH423 |
F | HOH430 |
site_id | FC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG E 308 |
Chain | Residue |
E | HOH461 |
E | HOH491 |
E | HOH518 |
E | HOH788 |
E | HOH821 |
site_id | FC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL F 301 |
Chain | Residue |
F | GLY25 |
F | ASP26 |
F | ARG29 |
F | HOH805 |
site_id | FC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL F 302 |
Chain | Residue |
F | ARG29 |
F | ALA238 |
F | ILE241 |
F | HOH447 |
F | HOH728 |
site_id | FC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 6MU F 303 |
Chain | Residue |
E | TRS305 |
F | THR93 |
F | GLY95 |
F | PHE161 |
F | GLN165 |
F | ARG167 |
F | PHE194 |
F | GLU195 |
F | MET196 |
F | ILE220 |
F | HOH416 |
site_id | FC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG F 304 |
Chain | Residue |
F | GLN180 |
F | HOH594 |
F | HOH605 |
F | HOH607 |
F | HOH676 |
F | HOH827 |
site_id | FC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG F 305 |
Chain | Residue |
F | ASN102 |
F | MG306 |
F | HOH468 |
F | HOH501 |
site_id | FC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG F 306 |
Chain | Residue |
F | MG305 |
F | HOH468 |
F | HOH501 |
F | HOH558 |
site_id | FC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO F 307 |
Chain | Residue |
E | LYS3 |
E | GLN82 |
F | ASP169 |
F | THR170 |
F | PHE171 |
F | HOH523 |
site_id | FC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EOH F 308 |
Chain | Residue |
E | LEU120 |
E | HOH428 |
E | HOH437 |
F | ARG178 |
F | HOH571 |
F | HOH622 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
Chain | Residue | Details |
A | SER65-LEU80 |