4K6M
Crystal Structure of the full-length Japanese encephalitis virus NS5
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
A | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
B | 0004483 | molecular_function | mRNA (nucleoside-2'-O-)-methyltransferase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0032259 | biological_process | methylation |
B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE SAH A 1001 |
Chain | Residue |
A | SER56 |
A | HIS110 |
A | VAL130 |
A | ASP131 |
A | VAL132 |
A | PHE133 |
A | ASP146 |
A | SO41011 |
A | HOH1145 |
A | HOH1209 |
A | GLY58 |
A | GLY81 |
A | CYS82 |
A | GLY85 |
A | GLY86 |
A | TRP87 |
A | THR104 |
A | LYS105 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
Chain | Residue |
A | ARG41 |
A | ARG45 |
A | HOH1116 |
A | HOH1192 |
B | THR38 |
B | ARG41 |
B | HOH1219 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
Chain | Residue |
A | ARG28 |
A | ARG41 |
A | ARG57 |
A | ARG213 |
B | ARG45 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
Chain | Residue |
A | ARG37 |
A | ARG41 |
A | ARG44 |
A | ARG84 |
A | HOH1142 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
Chain | Residue |
A | ALA31 |
A | ARG243 |
A | ARG246 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
Chain | Residue |
A | ARG28 |
A | SER215 |
A | ASN216 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
Chain | Residue |
A | ALA410 |
A | LEU411 |
A | GLY412 |
A | HOH1153 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
Chain | Residue |
A | ARG734 |
A | ARG742 |
A | SER799 |
A | TRP800 |
A | SER801 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1009 |
Chain | Residue |
A | ARG474 |
A | GLY539 |
A | LYS694 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 1010 |
Chain | Residue |
A | GLY561 |
A | ARG564 |
B | GLN635 |
B | HIS636 |
B | LYS643 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 1011 |
Chain | Residue |
A | GLY109 |
A | HIS110 |
A | GLU111 |
A | SAH1001 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1012 |
Chain | Residue |
A | GLU440 |
A | HIS444 |
A | CYS449 |
A | CYS452 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1013 |
Chain | Residue |
A | HIS717 |
A | CYS733 |
A | GLU848 |
A | CYS852 |
site_id | BC5 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE SAH B 1001 |
Chain | Residue |
B | SER56 |
B | GLY58 |
B | GLY81 |
B | CYS82 |
B | GLY85 |
B | GLY86 |
B | TRP87 |
B | THR104 |
B | LYS105 |
B | HIS110 |
B | VAL130 |
B | ASP131 |
B | VAL132 |
B | PHE133 |
B | ASP146 |
B | ILE147 |
B | SO41009 |
B | HOH1125 |
B | HOH1162 |
B | HOH1252 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
Chain | Residue |
A | ARG42 |
A | ARG45 |
B | ARG28 |
B | ARG41 |
B | ARG57 |
B | ARG213 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1003 |
Chain | Residue |
B | HOH1215 |
B | ARG37 |
B | ARG41 |
B | ARG84 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 1004 |
Chain | Residue |
B | ALA31 |
B | ARG243 |
B | ARG246 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 1005 |
Chain | Residue |
B | ARG28 |
B | SER215 |
B | ASN216 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 1006 |
Chain | Residue |
B | ALA410 |
B | LEU411 |
B | GLY412 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1007 |
Chain | Residue |
B | ARG734 |
B | SER799 |
B | TRP800 |
B | SER801 |
site_id | CC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 1008 |
Chain | Residue |
B | ARG474 |
B | GLY539 |
B | LYS694 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1009 |
Chain | Residue |
B | GLY109 |
B | HIS110 |
B | GLU111 |
B | SAH1001 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 1010 |
Chain | Residue |
B | HIS717 |
B | CYS733 |
B | GLU848 |
B | CYS852 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 1011 |
Chain | Residue |
B | GLU440 |
B | HIS444 |
B | CYS449 |
B | CYS452 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: For 2'-O-MTase activity => ECO:0000250|UniProtKB:Q6YMS4 |
Chain | Residue | Details |
A | LYS61 | |
A | ASP146 | |
A | LYS182 | |
A | GLU218 | |
B | LYS61 | |
B | ASP146 | |
B | LYS182 | |
B | GLU218 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | SER56 | |
B | SER56 | |
B | GLY86 | |
B | TRP87 | |
B | THR104 | |
B | LYS105 | |
B | ASP131 | |
B | VAL132 | |
B | ILE147 | |
B | TYR220 | |
A | GLY86 | |
A | TRP87 | |
A | THR104 | |
A | LYS105 | |
A | ASP131 | |
A | VAL132 | |
A | ILE147 | |
A | TYR220 |
site_id | SWS_FT_FI3 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24293643 |
Chain | Residue | Details |
A | GLU440 | |
B | CYS449 | |
B | CYS452 | |
B | HIS717 | |
B | CYS733 | |
B | CYS852 | |
A | HIS444 | |
A | CYS449 | |
A | CYS452 | |
A | HIS717 | |
A | CYS733 | |
A | CYS852 | |
B | GLU440 | |
B | HIS444 |
site_id | SWS_FT_FI4 |
Number of Residues | 14 |
Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS13 | |
B | PHE24 | |
B | ARG28 | |
B | SER150 | |
B | ARG213 | |
B | SER215 | |
A | ASN17 | |
A | PHE24 | |
A | ARG28 | |
A | SER150 | |
A | ARG213 | |
A | SER215 | |
B | LYS13 | |
B | ASN17 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LEU16 | |
A | MET19 | |
B | LEU16 | |
B | MET19 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | LYS61 | |
A | LYS182 | |
A | GLU218 | |
B | LYS61 | |
B | LYS182 | |
B | GLU218 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924 |
Chain | Residue | Details |
A | ASP146 | |
B | ASP146 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314 |
Chain | Residue | Details |
A | SER56 | |
B | SER56 |