4K6I

Crystal structure of human retinoid X receptor alpha-ligand binding domain complex with Targretin and the coactivator peptide GRIP-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 9RA A 500

Chain	Residue
A	ILE268
A	ILE345
A	HOH607
A	ALA271
A	ALA272
A	GLN275
A	LEU309
A	PHE313
A	ARG316
A	LEU326
A	ALA327

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR CHAIN B OF NUCLEAR RECEPTOR COACTIVATOR 2

Chain	Residue
A	ASP263
A	VAL265
A	PHE277
A	VAL280
A	LYS284
A	GLN297
A	VAL298
A	LEU301
A	ARG302
A	SER339
A	ALA340
A	GLY341
A	LYS431
A	PHE438
A	PHE439
A	ASP444
A	THR445
A	PHE450
A	GLU453
A	HOH648

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

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