4K4J

Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9cUAB30 and the coactivator peptide GRIP-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1O8 A 500

Chain	Residue
A	ILE268
A	LEU436
A	HOH624
A	ALA271
A	ALA272
A	GLN275
A	PHE313
A	ARG316
A	LEU326
A	ALA327
A	CYS432

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site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR CHAIN B OF NUCLEAR RECEPTOR COACTIVATOR 2 PEPTIDE

Chain	Residue
A	ASP263
A	VAL265
A	PHE277
A	VAL280
A	LYS284
A	LEU294
A	GLN297
A	VAL298
A	ARG302
A	SER339
A	ALA340
A	LYS431
A	PHE438
A	PHE439
A	ASP444
A	THR445
A	THR449
A	PHE450
A	GLU453
A	HOH710
B	HOH701

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6

Chain	Residue	Details
A	ARG316
A	ALA327

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER259

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700

Chain	Residue	Details
A	SER260

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