4K2P
The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0090630 | biological_process | activation of GTPase activity |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0090630 | biological_process | activation of GTPase activity |
| C | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| C | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0090630 | biological_process | activation of GTPase activity |
| D | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| D | 0007264 | biological_process | small GTPase-mediated signal transduction |
| D | 0090630 | biological_process | activation of GTPase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1001 |
| Chain | Residue |
| A | ASN610 |
| A | HOH1117 |
| A | HOH1144 |
| A | HOH1149 |
| A | HOH1187 |
| A | HOH1238 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1002 |
| Chain | Residue |
| B | HOH1266 |
| B | HOH1269 |
| B | HOH1279 |
| A | GLU557 |
| A | HOH1289 |
| B | GLU557 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 1001 |
| Chain | Residue |
| B | ASN610 |
| B | HOH1154 |
| B | HOH1188 |
| B | HOH1225 |
| B | HOH1236 |
| B | HOH1280 |
| B | HOH1295 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 1001 |
| Chain | Residue |
| C | ASN610 |
| C | HOH1160 |
| C | HOH1263 |
| C | HOH1281 |
| C | HOH1282 |
| C | HOH1299 |
| C | HOH1300 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA D 1001 |
| Chain | Residue |
| D | ASN610 |
| D | HOH1117 |
| D | HOH1144 |
| D | HOH1148 |
| D | HOH1218 |
| D | HOH1241 |
| D | HOH1255 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 230 |
| Details | Domain: {"description":"PH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00145","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
