4K0W

X-ray crystal structure of OXA-23 A220 duplication clinical variant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CIT A 301

Chain	Residue
A	SER79
A	ARG260
A	HOH508
A	HOH536
A	HOH537
A	HOH543
A	HOH673
A	LYS82
A	MET123
A	LEU125
A	SER126
A	LYS216
A	THR217
A	GLY218
A	TRP219

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	LYS194
A	ASN198
A	HOH412

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 303

Chain	Residue
A	HIS186
A	GLN188
A	HOH564
A	HOH583
A	HOH684

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 304

Chain	Residue
A	PRO256
A	ALA257
A	LYS269
A	NA311
A	HOH417
A	HOH469
A	HOH600
A	HOH618

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	HIS36
A	GLN270
A	LEU271
A	ASN272
A	HOH483
A	HOH496

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BCT A 306

Chain	Residue
A	THR49
A	SER50
A	ASN66

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BCT A 307

Chain	Residue
A	VAL33
A	GLN34
A	LYS60
A	ASN62
A	BCT309

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BCT A 308

Chain	Residue
A	THR73
A	HOH416
A	HOH545
A	HOH608

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BCT A 309

Chain	Residue
A	GLN31
A	VAL33
A	LYS60
A	ILE61
A	BCT307

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 310

Chain	Residue
A	SER253
A	ASN261
A	HOH418
A	HOH476
A	HOH589

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 311

Chain	Residue
A	LYS269
A	ASN272
A	ILE274
A	EDO304

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 312

Chain	Residue
A	LYS82
A	VAL128
A	TYR131
A	TRP165
A	HOH470

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 313

Chain	Residue
A	GLU99
A	ILE100
A	HOH458

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 314

Chain	Residue
A	TYR75
A	VAL76
A	HOH490
A	HOH545
A	HOH550

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"24012371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30530607","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6N6U","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4JF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24012371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30530607","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6N6U","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4JF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"24012371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30530607","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35420470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T7G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---