4K06
Crystal structure of MTX-II from Bothrops brazili venom complexed with polyethylene glycol
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004623 | molecular_function | phospholipase A2 activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005543 | molecular_function | phospholipid binding |
A | 0005576 | cellular_component | extracellular region |
A | 0006644 | biological_process | phospholipid metabolic process |
A | 0016042 | biological_process | lipid catabolic process |
A | 0035821 | biological_process | modulation of process of another organism |
A | 0042130 | biological_process | negative regulation of T cell proliferation |
A | 0042742 | biological_process | defense response to bacterium |
A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
A | 0050482 | biological_process | arachidonic acid secretion |
A | 0090729 | molecular_function | toxin activity |
B | 0004623 | molecular_function | phospholipase A2 activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0005543 | molecular_function | phospholipid binding |
B | 0005576 | cellular_component | extracellular region |
B | 0006644 | biological_process | phospholipid metabolic process |
B | 0016042 | biological_process | lipid catabolic process |
B | 0035821 | biological_process | modulation of process of another organism |
B | 0042130 | biological_process | negative regulation of T cell proliferation |
B | 0042742 | biological_process | defense response to bacterium |
B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
B | 0050482 | biological_process | arachidonic acid secretion |
B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGE A 201 |
Chain | Residue |
A | LEU2 |
A | GLY6 |
A | PRO19 |
A | TYR23 |
A | GLY24 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 202 |
Chain | Residue |
A | HOH329 |
A | HOH355 |
B | LYS36 |
B | HOH397 |
A | THR82 |
A | ILE105 |
A | ARG108 |
A | HOH307 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 203 |
Chain | Residue |
A | GLY34 |
A | ARG35 |
A | LYS57 |
A | HOH366 |
A | HOH372 |
A | HOH396 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 204 |
Chain | Residue |
A | LYS116 |
A | ARG119 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PE4 B 201 |
Chain | Residue |
B | LYS7 |
B | LEU10 |
B | GLN11 |
B | TYR75 |
B | TRP77 |
B | 7PE204 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 202 |
Chain | Residue |
B | GLY15 |
B | LYS16 |
B | ASN17 |
B | HOH399 |
B | HOH427 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 203 |
Chain | Residue |
B | THR59 |
B | LYS115 |
B | ARG118 |
B | HOH380 |
B | HOH403 |
B | HOH418 |
site_id | AC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 7PE B 204 |
Chain | Residue |
A | PRO125 |
B | LEU2 |
B | GLY6 |
B | LEU10 |
B | PRO18 |
B | TYR22 |
B | PE4201 |
B | HOH377 |
B | HOH413 |
B | HOH414 |
B | HOH422 |
B | HOH428 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000269|PubMed:24145104 |
Chain | Residue | Details |
A | LYS116 | |
A | ARG119 | |
B | LYS115 | |
B | ARG118 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000269|PubMed:24145104 |
Chain | Residue | Details |
A | LEU122 | |
A | PHE126 | |
B | LEU121 | |
B | PHE125 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000269|PubMed:24145104 |
Chain | Residue | Details |
A | LYS123 | |
A | LYS130 | |
B | LYS122 | |
B | LYS129 |