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4JZQ

Crystal structure of human CLIC1 C24D mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
A0031965cellular_componentnuclear membrane
A0031982cellular_componentvesicle
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0034707cellular_componentchloride channel complex
A0045296molecular_functioncadherin binding
A0045669biological_processpositive regulation of osteoblast differentiation
A0048471cellular_componentperinuclear region of cytoplasm
A0051881biological_processregulation of mitochondrial membrane potential
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0072562cellular_componentblood microparticle
A1902476biological_processchloride transmembrane transport
B0005254molecular_functionchloride channel activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
B0031965cellular_componentnuclear membrane
B0031982cellular_componentvesicle
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0034707cellular_componentchloride channel complex
B0045296molecular_functioncadherin binding
B0045669biological_processpositive regulation of osteoblast differentiation
B0048471cellular_componentperinuclear region of cytoplasm
B0051881biological_processregulation of mitochondrial membrane potential
B0070062cellular_componentextracellular exosome
B0070527biological_processplatelet aggregation
B0072562cellular_componentblood microparticle
B1902476biological_processchloride transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsTRANSMEM: Helical; Note=After insertion into the membrane => ECO:0000255
ChainResidueDetails
APHE26-VAL46
BPHE26-VAL46

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11551966
ChainResidueDetails
BLEU64
BTHR77
ALEU64
ATHR77

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS131
BLYS13
BLYS119
BLYS131
ALYS13
ALYS119

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:14613939
ChainResidueDetails
AASP24
BASP24

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER211
BSER121
BSER156
BSER211
ASER121
ASER156

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1Q5
ChainResidueDetails
ATYR233
BTYR233

218500

PDB entries from 2024-04-17

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