4JTA

Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0014069	cellular_component	postsynaptic density
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030424	cellular_component	axon
A	0034705	cellular_component	potassium channel complex
A	0043005	cellular_component	neuron projection
A	0043194	cellular_component	axon initial segment
A	0043679	cellular_component	axon terminus
A	0044224	cellular_component	juxtaparanode region of axon
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0045445	biological_process	myoblast differentiation
A	0050905	biological_process	neuromuscular process
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990031	cellular_component	pinceau fiber
A	2000008	biological_process	regulation of protein localization to cell surface
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
P	0002244	biological_process	hematopoietic progenitor cell differentiation
P	0005249	molecular_function	voltage-gated potassium channel activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0005886	cellular_component	plasma membrane
P	0006811	biological_process	monoatomic ion transport
P	0006813	biological_process	potassium ion transport
P	0008076	cellular_component	voltage-gated potassium channel complex
P	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
P	0009898	cellular_component	cytoplasmic side of plasma membrane
P	0014069	cellular_component	postsynaptic density
P	0015459	molecular_function	potassium channel regulator activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0030424	cellular_component	axon
P	0034705	cellular_component	potassium channel complex
P	0043005	cellular_component	neuron projection
P	0043194	cellular_component	axon initial segment
P	0043679	cellular_component	axon terminus
P	0044224	cellular_component	juxtaparanode region of axon
P	0044325	molecular_function	transmembrane transporter binding
P	0044877	molecular_function	protein-containing complex binding
P	0045202	cellular_component	synapse
P	0045445	biological_process	myoblast differentiation
P	0050905	biological_process	neuromuscular process
P	0055085	biological_process	transmembrane transport
P	0071805	biological_process	potassium ion transmembrane transport
P	0098839	cellular_component	postsynaptic density membrane
P	0098978	cellular_component	glutamatergic synapse
P	1901379	biological_process	regulation of potassium ion transmembrane transport
P	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
P	1990031	cellular_component	pinceau fiber
P	2000008	biological_process	regulation of protein localization to cell surface
Q	0005216	molecular_function	monoatomic ion channel activity
Q	0005249	molecular_function	voltage-gated potassium channel activity
Q	0006811	biological_process	monoatomic ion transport
Q	0006813	biological_process	potassium ion transport
Q	0008076	cellular_component	voltage-gated potassium channel complex
Q	0016020	cellular_component	membrane
Q	0051260	biological_process	protein homooligomerization
Q	0055085	biological_process	transmembrane transport
Y	0005576	cellular_component	extracellular region
Y	0008200	molecular_function	ion channel inhibitor activity
Y	0015459	molecular_function	potassium channel regulator activity
Y	0031640	biological_process	killing of cells of another organism
Y	0035821	biological_process	modulation of process of another organism
Y	0042742	biological_process	defense response to bacterium
Y	0050832	biological_process	defense response to fungus
Y	0090729	molecular_function	toxin activity
Y	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAP A 1001

Chain	Residue
A	GLY55
A	ARG189
A	GLN214
A	TRP243
A	SER244
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	GLY249
A	LYS254
A	THR56
A	SER263
A	ARG264
A	LEU321
A	GLY323
A	ALA324
A	SER325
A	GLN329
A	GLU332
A	ASN333
A	HOH1126
A	TRP57
A	HOH1140
A	HOH1141
A	HOH1148
A	HOH1167
A	GLN63
A	ASP85
A	TYR90
A	LYS118
A	ASN158
A	SER188

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K B 501

Chain	Residue
B	VAL371
B	VAL371
B	VAL371
B	VAL371
B	GLY372
B	GLY372
B	GLY372
B	GLY372
B	K502
B	K502
B	K502
B	K502

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K B 502

Chain	Residue
B	THR370
B	THR370
B	THR370
B	THR370
B	VAL371
B	VAL371
B	VAL371
B	VAL371
B	K501
B	K501
B	K501
B	K501
B	K503
B	K503
B	K503
B	K503

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K B 503

Chain	Residue
B	THR370
B	THR370
B	THR370
B	THR370
B	K502
B	K502
B	K502
B	K502

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGW B 504

Chain	Residue
B	PRO358
B	ASP359
B	PHE361
B	TRP362
B	VAL365
B	ILE381
B	LYS384
B	SER388

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGW B 505

Chain	Residue
B	ILE294
B	ALA345
B	PGW506

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGW B 506

Chain	Residue
B	PGW505
B	PGW508

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGW B 508

Chain	Residue
B	PGW506

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGW B 509

Chain	Residue
B	VAL178

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGW B 510

Chain	Residue
B	ILE328
B	LEU396
B	THR397
B	PGW511
B	PGW515

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGW B 511

Chain	Residue
B	MET321
B	PGW510

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGW B 513

Chain	Residue
B	PRO221
B	PHE222

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGW B 514

Chain	Residue
B	ILE328
B	SER307
B	LYS308
B	GLY309
B	ARG322
B	GLY325
B	LEU326

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGW B 515

Chain	Residue
B	PHE330
B	THR397
B	PGW510

---

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PGW B 516

Chain	Residue
B	ILE254
B	MET255
B	PHE301
B	LYS308
B	LEU310
B	GLN311
B	GLN315
B	LYS318
B	ARG415
B	GLU416

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGW B 517

Chain	Residue
B	GLN214
B	ILE231
B	GLU274

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGW B 518

Chain	Residue
B	PHE292

---

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGW B 519

Chain	Residue
B	PHE218

---

site_id	CC1
Number of Residues	35
Details	BINDING SITE FOR RESIDUE NAP P 1001

Chain	Residue
P	GLY55
P	THR56
P	TRP57
P	GLN63
P	ASP85
P	TYR90
P	ASN158
P	SER188
P	ARG189
P	GLN214
P	TRP243
P	SER244
P	PRO245
P	LEU246
P	ALA247
P	CYS248
P	GLY249
P	SER252
P	LYS254
P	TYR262
P	SER263
P	ARG264
P	PRO304
P	LEU321
P	LEU322
P	GLY323
P	SER325
P	GLN329
P	GLU332
P	ASN333
P	HOH1123
P	HOH1135
P	HOH1136
P	HOH1150
P	HOH1201

---

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K Q 501

Chain	Residue
Q	VAL371
Q	VAL371
Q	VAL371
Q	VAL371
Q	GLY372
Q	GLY372
Q	GLY372
Q	GLY372

---

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE K Q 502

Chain	Residue
Q	THR370
Q	THR370
Q	THR370
Q	THR370
Q	VAL371
Q	VAL371
Q	VAL371
Q	VAL371
Q	K503
Q	K503
Q	K503
Q	K503

---

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K Q 503

Chain	Residue
Q	THR370
Q	THR370
Q	THR370
Q	THR370
Q	K502
Q	K502
Q	K502
Q	K502

---

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGW Q 504

Chain	Residue
Q	PRO358
Q	PHE361
Q	TRP362
Q	VAL365
Q	ILE381
Q	LYS384
Q	SER388

---

Functional Information from PROSITE/UniProt

site_id	PS01138
Number of Residues	23
Details	SCORP_SHORT_TOXIN Scorpion short toxins signature. CwsvCqrlhntsr.GKCMnkkCrC

Chain	Residue	Details
Y	CYS13-CYS35

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18672894","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21357749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13303","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	42
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	64
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	24
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	22
Details	Intramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	14
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	10
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	38
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12151401","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	26
Details	Region: {"description":"S4-S5 linker","evidences":[{"source":"PubMed","id":"16002579","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Site: {"description":"Important for normal, slow channel gating","evidences":[{"source":"PubMed","id":"17766348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	Site: {"description":"Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin","evidences":[{"source":"PubMed","id":"25514171","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16770729","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	7
Details	Region: {"description":"Interaction with Ca(2+)-activated K(+) channels","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	Site: {"description":"Basic residue of the functional dyad","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---