4JRP
Structure of E. coli Exonuclease I in complex with a 5cy-dT13 oligonucleotide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003697 | molecular_function | single-stranded DNA binding |
A | 0004527 | molecular_function | exonuclease activity |
A | 0004529 | molecular_function | DNA exonuclease activity |
A | 0005515 | molecular_function | protein binding |
A | 0006281 | biological_process | DNA repair |
A | 0006308 | biological_process | DNA catabolic process |
A | 0008310 | molecular_function | single-stranded DNA 3'-5' DNA exonuclease activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0051575 | molecular_function | 5'-deoxyribose-5-phosphate lyase activity |
B | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003676 | molecular_function | nucleic acid binding |
B | 0003677 | molecular_function | DNA binding |
B | 0003697 | molecular_function | single-stranded DNA binding |
B | 0004527 | molecular_function | exonuclease activity |
B | 0004529 | molecular_function | DNA exonuclease activity |
B | 0005515 | molecular_function | protein binding |
B | 0006281 | biological_process | DNA repair |
B | 0006308 | biological_process | DNA catabolic process |
B | 0008310 | molecular_function | single-stranded DNA 3'-5' DNA exonuclease activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0051575 | molecular_function | 5'-deoxyribose-5-phosphate lyase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 101 |
Chain | Residue |
A | ASP15 |
A | HOH610 |
A | HOH611 |
A | HOH735 |
C | DT12 |
C | DT13 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 501 |
Chain | Residue |
A | ARG256 |
A | HOH601 |
B | HIS215 |
B | ARG256 |
B | HOH672 |
B | HOH695 |
A | LYS214 |
A | HIS215 |
A | MET218 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 A 502 |
Chain | Residue |
A | ARG106 |
A | SER233 |
A | MET235 |
A | LYS299 |
A | LEU300 |
A | HIS302 |
A | HOH644 |
A | HOH720 |
A | HOH746 |
A | HOH749 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 503 |
Chain | Residue |
A | PHE415 |
A | PRO416 |
A | GLY417 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 504 |
Chain | Residue |
A | ARG148 |
A | ARG203 |
A | ARG316 |
A | HOH682 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 505 |
Chain | Residue |
A | ARG35 |
A | GLY44 |
A | GLU45 |
A | GLU47 |
A | LEU91 |
A | HOH740 |
A | HOH741 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 506 |
Chain | Residue |
A | THR436 |
A | PRO437 |
A | GLU438 |
B | HIS430 |
B | GLN433 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 507 |
Chain | Residue |
A | HIS430 |
A | GLN433 |
A | HOH675 |
B | THR436 |
B | GLU438 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 501 |
Chain | Residue |
B | ARG148 |
B | ARG203 |
B | ALA393 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 502 |
Chain | Residue |
B | THR210 |
B | HIS211 |
B | LYS216 |
B | ARG389 |
B | ASN390 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 503 |
Chain | Residue |
B | HIS22 |
B | PRO23 |
B | ALA24 |
B | LEU25 |
B | HOH751 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 504 |
Chain | Residue |
B | ASN414 |
B | PHE415 |
B | PRO416 |
B | GLY417 |
B | HOH719 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 505 |
Chain | Residue |
B | ASN157 |
B | SER163 |
B | PHE164 |
B | ARG165 |
B | HIS168 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 506 |
Chain | Residue |
B | PRO228 |
B | LEU334 |
B | ARG338 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 507 |
Chain | Residue |
A | LYS216 |
B | SER373 |
B | ASP374 |
B | HOH688 |
site_id | BC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 B 508 |
Chain | Residue |
B | ARG200 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 509 |
Chain | Residue |
B | GLN129 |
B | LYS381 |
B | HOH601 |
B | HOH602 |
D | 5CY0 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE IPA B 510 |
Chain | Residue |
A | PHE439 |
A | GLY442 |
A | TYR443 |
A | HOH690 |
B | GLY442 |
B | TYR443 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11101894, ECO:0000269|PubMed:18219121, ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540 |
Chain | Residue | Details |
A | ASP15 | |
B | ASP15 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18219121 |
Chain | Residue | Details |
A | GLU17 | |
A | ARG165 | |
A | ASP186 | |
B | GLU17 | |
B | ARG165 | |
B | ASP186 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | SITE: Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540 |
Chain | Residue | Details |
A | THR18 | |
A | PHE371 | |
B | THR18 | |
B | ILE66 | |
B | ARG113 | |
B | TYR124 | |
B | TRP128 | |
B | ARG142 | |
B | LYS214 | |
B | TYR284 | |
B | TYR368 | |
A | ILE66 | |
B | PHE371 | |
A | ARG113 | |
A | TYR124 | |
A | TRP128 | |
A | ARG142 | |
A | LYS214 | |
A | TYR284 | |
A | TYR368 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | SITE: Important for interaction with ssb => ECO:0000269|PubMed:18591666 |
Chain | Residue | Details |
A | ARG148 | |
A | TYR207 | |
A | GLN311 | |
B | ARG148 | |
B | TYR207 | |
B | GLN311 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | SITE: Interaction with single-stranded DNA => ECO:0000269|PubMed:23609540, ECO:0007744|PDB:4HCC |
Chain | Residue | Details |
A | PHE164 | |
A | ASN257 | |
A | ASN304 | |
B | PHE164 | |
B | ASN257 | |
B | ASN304 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | SITE: Important for activity => ECO:0000269|PubMed:23609540 |
Chain | Residue | Details |
A | HIS181 | |
B | HIS181 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Important for interaction with ssb => ECO:0000305|PubMed:20018747 |
Chain | Residue | Details |
A | ARG338 | |
B | ARG338 |