Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JPH

Crystal structure of Protein Related to DAN and Cerberus (PRDC)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008201	molecular_function	heparin binding
A	0009966	biological_process	regulation of signal transduction
A	0010172	biological_process	embryonic body morphogenesis
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0036122	molecular_function	BMP binding
A	0038098	biological_process	sequestering of BMP from receptor via BMP binding
A	0042802	molecular_function	identical protein binding
A	0048018	molecular_function	receptor ligand activity
A	0048263	biological_process	determination of dorsal identity
A	0060300	biological_process	regulation of cytokine activity
B	0005125	molecular_function	cytokine activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0008201	molecular_function	heparin binding
B	0009966	biological_process	regulation of signal transduction
B	0010172	biological_process	embryonic body morphogenesis
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0030514	biological_process	negative regulation of BMP signaling pathway
B	0036122	molecular_function	BMP binding
B	0038098	biological_process	sequestering of BMP from receptor via BMP binding
B	0042802	molecular_function	identical protein binding
B	0048018	molecular_function	receptor ligand activity
B	0048263	biological_process	determination of dorsal identity
B	0060300	biological_process	regulation of cytokine activity
C	0005125	molecular_function	cytokine activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0008201	molecular_function	heparin binding
C	0009966	biological_process	regulation of signal transduction
C	0010172	biological_process	embryonic body morphogenesis
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030514	biological_process	negative regulation of BMP signaling pathway
C	0036122	molecular_function	BMP binding
C	0038098	biological_process	sequestering of BMP from receptor via BMP binding
C	0042802	molecular_function	identical protein binding
C	0048018	molecular_function	receptor ligand activity
C	0048263	biological_process	determination of dorsal identity
C	0060300	biological_process	regulation of cytokine activity
D	0005125	molecular_function	cytokine activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0008201	molecular_function	heparin binding
D	0009966	biological_process	regulation of signal transduction
D	0010172	biological_process	embryonic body morphogenesis
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030514	biological_process	negative regulation of BMP signaling pathway
D	0036122	molecular_function	BMP binding
D	0038098	biological_process	sequestering of BMP from receptor via BMP binding
D	0042802	molecular_function	identical protein binding
D	0048018	molecular_function	receptor ligand activity
D	0048263	biological_process	determination of dorsal identity
D	0060300	biological_process	regulation of cytokine activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 201

Chain	Residue
A	GLU58
B	ARG79

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 202

Chain	Residue
A	ILE49

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	ARG108
A	HIS109
A	LYS111
A	ASP115

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 204

Chain	Residue
A	CYS157
A	MET158

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 205

Chain	Residue
A	GLU84
A	ARG145
B	SER89

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GSH A 206

Chain	Residue
A	TYR105
A	GLN118
A	CYS120
A	VAL160
B	PHE122
B	LYS124
B	PRO125
B	GSH205

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT B 201

Chain	Residue
B	ARG95
B	ARG127
B	LYS153
D	ARG90
D	ILE132
D	HOH301
D	HOH304
D	HOH310

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 202

Chain	Residue
B	HIS154
D	THR129
D	SER130

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 203

Chain	Residue
B	GLU64
B	GLN118

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL B 204

Chain	Residue
B	PHE144

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GSH B 205

Chain	Residue
A	PHE122
A	LYS124
A	GSH206
B	GLN118
B	CYS120

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 201

Chain	Residue
C	HIS154
C	ARG156
C	HOH312

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL C 202

Chain	Residue
C	ARG95
C	LYS153

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 203

Chain	Residue
B	GLU85
B	GLY86
C	ARG79
C	LEU93
C	HOH302

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GSH C 204

Chain	Residue
C	GLN118
C	CYS120

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CIT D 201

Chain	Residue
B	GLN126
B	ARG127
B	ARG156
D	LYS151
D	LYS153

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 202

Chain	Residue
B	ARG79
B	THR91
D	PRO142
D	PHE144

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GSH D 203

Chain	Residue
C	PHE122
D	GLN118
D	CYS120

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)