4JLX
Structure of porcine cyclic GMP-AMP synthase (cGAS)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | HIS367 |
| A | CYS373 |
| A | CYS374 |
| A | CYS381 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MLI A 502 |
| Chain | Residue |
| A | LEU214 |
| A | PRO308 |
| A | ALA309 |
| A | HOH698 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | HIS166 |
| A | HIS166 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MLI A 504 |
| Chain | Residue |
| A | GLU215 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PG4 A 505 |
| Chain | Residue |
| A | ARG404 |
| A | GLY464 |
| A | ASN466 |
| A | SER469 |
| A | ARG470 |
| A | PHE480 |
| A | LYS483 |
| A | GLN484 |
| A | MLI507 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 A 506 |
| Chain | Residue |
| A | ASP426 |
| A | ASN430 |
| A | GLN431 |
| A | TRP432 |
| A | HIS433 |
| A | ASN436 |
| A | CYS439 |
| A | CYS440 |
| A | ASN443 |
| A | HOH654 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MLI A 507 |
| Chain | Residue |
| A | LYS400 |
| A | ARG470 |
| A | ASP471 |
| A | GLN484 |
| A | TYR487 |
| A | PG4505 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23722159 |
| Chain | Residue | Details |
| A | SER188 | |
| A | GLU200 | |
| A | ASP202 | |
| A | ASP296 | |
| A | GLU360 | |
| A | HIS367 | |
| A | CYS373 | |
| A | CYS374 | |
| A | CYS381 | |
| A | LYS391 | |
| A | SER412 | |
| A | THR186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | ARG353 | |
| A | LYS339 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Arginine-anchor => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | ARG230 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | ASP296 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | GLU165 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | SER280 | |
| A | SER412 | |
| A | SER188 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | TYR190 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | GLU261 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS391 | |
| A | LYS371 | |
| A | LYS361 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS483 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | CYS382 | |
| A | CYS451 | |
| A | CYS381 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | LYS371 | |
| A | LYS206 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS391 | |
| A | LYS388 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | LYS260 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8C6L5 |
| Chain | Residue | Details |
| A | LYS324 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8N884 |
| Chain | Residue | Details |
| A | LYS361 |
