Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | ARG175 |
| A | ARG178 |
| A | GLY537 |
| A | HOH745 |
| B | ALA188 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP A 602 |
| Chain | Residue |
| A | GLY73 |
| A | LYS74 |
| A | THR75 |
| A | THR76 |
| A | GLY113 |
| A | GLY114 |
| A | GLU301 |
| A | ASN382 |
| A | ALA383 |
| A | PHE384 |
| A | PRO385 |
| A | TRP412 |
| A | XPO603 |
| A | MG605 |
| A | HOH784 |
| A | ASP7 |
| A | ALA70 |
| A | GLY71 |
| A | GLU72 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE XPO A 603 |
| Chain | Residue |
| A | LYS74 |
| A | ARG97 |
| A | LYS108 |
| A | PHE275 |
| A | ALA276 |
| A | GLU301 |
| A | GLY303 |
| A | PHE304 |
| A | ADP602 |
| A | MG605 |
| A | HOH785 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE TOE A 604 |
| Chain | Residue |
| A | ARG162 |
| A | ILE164 |
| A | GLU194 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 605 |
| Chain | Residue |
| A | THR75 |
| A | GLU301 |
| A | ADP602 |
| A | XPO603 |
| A | HOH784 |
| A | HOH785 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 601 |
| Chain | Residue |
| A | ALA188 |
| B | ARG175 |
| B | ARG178 |
| B | GLY537 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP B 602 |
| Chain | Residue |
| B | GLU9 |
| B | ALA70 |
| B | GLU72 |
| B | GLY73 |
| B | LYS74 |
| B | THR75 |
| B | THR76 |
| B | LYS108 |
| B | GLY113 |
| B | GLY114 |
| B | GLU301 |
| B | ASN382 |
| B | ALA383 |
| B | PHE384 |
| B | PRO385 |
| B | TRP412 |
| B | XPO603 |
| B | MG606 |
| B | HOH716 |
| B | HOH742 |
| B | HOH774 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE XPO B 603 |
| Chain | Residue |
| B | PRO67 |
| B | GLY71 |
| B | LYS74 |
| B | ARG97 |
| B | LYS108 |
| B | PHE275 |
| B | ALA276 |
| B | GLU301 |
| B | GLY303 |
| B | PHE304 |
| B | ADP602 |
| B | MG606 |
| B | HOH716 |
| B | HOH749 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TOE B 604 |
| Chain | Residue |
| B | ARG162 |
| B | ILE164 |
| B | GLU194 |
| B | GLU515 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1PE B 605 |
| Chain | Residue |
| B | PRO161 |
| B | ARG162 |
| B | GLY186 |
| B | VAL191 |
| B | PRO192 |
| B | PRO192 |
| B | ARG193 |
| B | GLU194 |
| B | HOH757 |
| B | HOH775 |
| B | HOH775 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 606 |
| Chain | Residue |
| B | GLU301 |
| B | ADP602 |
| B | XPO603 |
| B | HOH749 |
| B | HOH774 |
| B | THR75 |
Functional Information from PROSITE/UniProt
| site_id | PS00721 |
| Number of Residues | 11 |
| Details | FTHFS_1 Formate--tetrahydrofolate ligase signature 1. GIKGGAAGGGY |
| Chain | Residue | Details |
| A | GLY106-TYR116 | |
| site_id | PS00722 |
| Number of Residues | 12 |
| Details | FTHFS_2 Formate--tetrahydrofolate ligase signature 2. VATVRALKmHGG |
| Chain | Residue | Details |
| A | VAL331-GLY342 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | THR68 | |
| B | THR68 | |
