Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FOL A 601 |
| Chain | Residue |
| A | ALA383 |
| A | PHE384 |
| A | PRO385 |
| A | GLU389 |
| A | TYR396 |
| A | LEU408 |
| A | TRP412 |
| A | GLU417 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 602 |
| Chain | Residue |
| A | ARG476 |
| A | EDO603 |
| A | ALA473 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 603 |
| Chain | Residue |
| A | LYS187 |
| A | EDO602 |
| A | HOH757 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 604 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TOE A 605 |
| Chain | Residue |
| A | ARG162 |
| A | ILE164 |
| A | GLU194 |
| A | HOH743 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE TOE A 606 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | ARG175 |
| A | ARG178 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | SER44 |
| A | LYS256 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 609 |
| Chain | Residue |
| A | SER446 |
| A | LYS448 |
| A | ARG505 |
| A | ARG507 |
| A | HOH770 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 610 |
| Chain | Residue |
| A | LYS74 |
| A | ARG97 |
| A | GLY303 |
| A | PHE304 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE TOE B 601 |
| Chain | Residue |
| B | ARG162 |
| B | ILE164 |
| B | GLU194 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| A | ALA188 |
| B | ARG175 |
| B | ARG178 |
| B | MET533 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | LYS74 |
| B | ARG97 |
| B | GLY303 |
| B | PHE304 |
Functional Information from PROSITE/UniProt
| site_id | PS00721 |
| Number of Residues | 11 |
| Details | FTHFS_1 Formate--tetrahydrofolate ligase signature 1. GIKGGAAGGGY |
| Chain | Residue | Details |
| A | GLY106-TYR116 | |
| site_id | PS00722 |
| Number of Residues | 12 |
| Details | FTHFS_2 Formate--tetrahydrofolate ligase signature 2. VATVRALKmHGG |
| Chain | Residue | Details |
| A | VAL331-GLY342 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | THR68 | |
| B | THR68 | |
