4JIN

X-ray crystal structure of Archaeoglobus fulgidus Rio1 bound to (2E)-N-benzyl-2-cyano-3-(pyridine-4-yl)acrylamide (WP1086)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0030490	biological_process	maturation of SSU-rRNA
A	0030688	cellular_component	preribosome, small subunit precursor
A	0046872	molecular_function	metal ion binding
A	0106310	molecular_function	protein serine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1L7 A 301

Chain	Residue
A	ILE55
A	HOH469
A	HOH471
A	SER56
A	ALA61
A	LYS80
A	GLU148
A	ILE150
A	ILE211
A	ASP212
A	HOH452

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Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHaDLSEYNIMY

Chain	Residue	Details
A	LEU192-TYR204

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site_id	PS01245
Number of Residues	12
Details	RIO1 RIO1/ZK632.3/MJ0444 family signature. LVHADLSEYNiM

Chain	Residue	Details
A	LEU192-MET203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q9BRS2, ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP196

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250|UniProtKB:Q9BRS2

Chain	Residue	Details
A	ASP212

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE55

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:16008568, ECO:0007744|PDB:1ZP9

Chain	Residue	Details
A	LYS80

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:16008568, ECO:0007744|PDB:1ZP9

Chain	Residue	Details
A	GLU148
A	ILE150

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site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O30245

Chain	Residue	Details
A	TYR200

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site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:16008568

Chain	Residue	Details
A	ASN201
A	ASP212

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:16008568

Chain	Residue	Details
A	SER108

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