Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JHD

Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000281	biological_process	mitotic cytokinesis
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005856	cellular_component	cytoskeleton
A	0006338	biological_process	chromatin remodeling
A	0007010	biological_process	cytoskeleton organization
A	0007291	biological_process	sperm individualization
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030723	biological_process	ovarian fusome organization
A	0031011	cellular_component	Ino80 complex
A	0032507	biological_process	maintenance of protein location in cell
A	0035060	cellular_component	brahma complex
A	0035148	biological_process	tube formation
A	0048468	biological_process	cell development
A	0048646	biological_process	anatomical structure formation involved in morphogenesis
B	0000166	molecular_function	nucleotide binding
B	0000281	biological_process	mitotic cytokinesis
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005856	cellular_component	cytoskeleton
B	0006338	biological_process	chromatin remodeling
B	0007010	biological_process	cytoskeleton organization
B	0007291	biological_process	sperm individualization
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030723	biological_process	ovarian fusome organization
B	0031011	cellular_component	Ino80 complex
B	0032507	biological_process	maintenance of protein location in cell
B	0035060	cellular_component	brahma complex
B	0035148	biological_process	tube formation
B	0048468	biological_process	cell development
B	0048646	biological_process	anatomical structure formation involved in morphogenesis
C	0003779	molecular_function	actin binding
C	0003785	molecular_function	actin monomer binding
D	0000166	molecular_function	nucleotide binding
D	0000281	biological_process	mitotic cytokinesis
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005856	cellular_component	cytoskeleton
D	0006338	biological_process	chromatin remodeling
D	0007010	biological_process	cytoskeleton organization
D	0007291	biological_process	sperm individualization
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030723	biological_process	ovarian fusome organization
D	0031011	cellular_component	Ino80 complex
D	0032507	biological_process	maintenance of protein location in cell
D	0035060	cellular_component	brahma complex
D	0035148	biological_process	tube formation
D	0048468	biological_process	cell development
D	0048646	biological_process	anatomical structure formation involved in morphogenesis
E	0000166	molecular_function	nucleotide binding
E	0000281	biological_process	mitotic cytokinesis
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005856	cellular_component	cytoskeleton
E	0006338	biological_process	chromatin remodeling
E	0007010	biological_process	cytoskeleton organization
E	0007291	biological_process	sperm individualization
E	0015629	cellular_component	actin cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030723	biological_process	ovarian fusome organization
E	0031011	cellular_component	Ino80 complex
E	0032507	biological_process	maintenance of protein location in cell
E	0035060	cellular_component	brahma complex
E	0035148	biological_process	tube formation
E	0048468	biological_process	cell development
E	0048646	biological_process	anatomical structure formation involved in morphogenesis
F	0003779	molecular_function	actin binding
F	0003785	molecular_function	actin monomer binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ANP A 401

Chain	Residue
A	GLY13
A	GLY182
A	ARG210
A	LYS213
A	GLU214
A	GLY302
A	THR303
A	MET305
A	TYR306
A	MG402
C	TYR101
A	SER14
A	GLY15
A	MET16
A	LYS18
A	GLY156
A	ASP157
A	GLY158
A	VAL159

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ANP401

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ANP B 401

Chain	Residue
B	GLY13
B	SER14
B	GLY15
B	MET16
B	LYS18
B	GLY156
B	ASP157
B	GLY158
B	GLY182
B	LYS213
B	GLU214
B	GLY301
B	GLY302
B	THR303
B	MET305
B	TYR306
B	LYS336
B	MG402
B	HOH502
B	HOH508
B	HOH521
C	ALA145

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 402

Chain	Residue
B	ANP401
B	HOH502

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ANP D 401

Chain	Residue
D	GLY13
D	SER14
D	GLY15
D	MET16
D	LYS18
D	GLY156
D	ASP157
D	GLY158
D	GLY182
D	ARG210
D	LYS213
D	GLU214
D	GLY302
D	THR303
D	MET305
D	TYR306
D	MG402
D	HOH518
D	HOH528
F	TYR101

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 402

Chain	Residue
D	ANP401
D	HOH528

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP E 401

Chain	Residue
E	GLY13
E	SER14
E	GLY15
E	MET16
E	LYS18
E	GLY156
E	ASP157
E	GLY158
E	GLY182
E	LYS213
E	GLU214
E	GLY302
E	THR303
E	MET305
E	TYR306
E	LYS336
E	MG402

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 402

Chain	Residue
E	ANP401
E	HOH502

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63
B	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364
B	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116
B	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Modified residue: {"description":"Methionine sulfoxide","evidences":[{"source":"PubMed","id":"22116028","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P02572","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Domain: {"description":"WH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00406","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Domain: {"description":"WH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00406","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	58
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	34
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)