4JHD
Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0007010 | biological_process | cytoskeleton organization |
| A | 0007291 | biological_process | sperm individualization |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030723 | biological_process | ovarian fusome organization |
| A | 0031011 | cellular_component | Ino80 complex |
| A | 0032507 | biological_process | maintenance of protein location in cell |
| A | 0035060 | cellular_component | brahma complex |
| A | 0035148 | biological_process | tube formation |
| A | 0048468 | biological_process | cell development |
| A | 0048646 | biological_process | anatomical structure formation involved in morphogenesis |
| B | 0000281 | biological_process | mitotic cytokinesis |
| B | 0005200 | molecular_function | structural constituent of cytoskeleton |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0007010 | biological_process | cytoskeleton organization |
| B | 0007291 | biological_process | sperm individualization |
| B | 0015629 | cellular_component | actin cytoskeleton |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0030723 | biological_process | ovarian fusome organization |
| B | 0031011 | cellular_component | Ino80 complex |
| B | 0032507 | biological_process | maintenance of protein location in cell |
| B | 0035060 | cellular_component | brahma complex |
| B | 0035148 | biological_process | tube formation |
| B | 0048468 | biological_process | cell development |
| B | 0048646 | biological_process | anatomical structure formation involved in morphogenesis |
| C | 0003779 | molecular_function | actin binding |
| C | 0003785 | molecular_function | actin monomer binding |
| D | 0000281 | biological_process | mitotic cytokinesis |
| D | 0005200 | molecular_function | structural constituent of cytoskeleton |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005856 | cellular_component | cytoskeleton |
| D | 0006338 | biological_process | chromatin remodeling |
| D | 0007010 | biological_process | cytoskeleton organization |
| D | 0007291 | biological_process | sperm individualization |
| D | 0015629 | cellular_component | actin cytoskeleton |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0030723 | biological_process | ovarian fusome organization |
| D | 0031011 | cellular_component | Ino80 complex |
| D | 0032507 | biological_process | maintenance of protein location in cell |
| D | 0035060 | cellular_component | brahma complex |
| D | 0035148 | biological_process | tube formation |
| D | 0048468 | biological_process | cell development |
| D | 0048646 | biological_process | anatomical structure formation involved in morphogenesis |
| E | 0000281 | biological_process | mitotic cytokinesis |
| E | 0005200 | molecular_function | structural constituent of cytoskeleton |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0006338 | biological_process | chromatin remodeling |
| E | 0007010 | biological_process | cytoskeleton organization |
| E | 0007291 | biological_process | sperm individualization |
| E | 0015629 | cellular_component | actin cytoskeleton |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0030723 | biological_process | ovarian fusome organization |
| E | 0031011 | cellular_component | Ino80 complex |
| E | 0032507 | biological_process | maintenance of protein location in cell |
| E | 0035060 | cellular_component | brahma complex |
| E | 0035148 | biological_process | tube formation |
| E | 0048468 | biological_process | cell development |
| E | 0048646 | biological_process | anatomical structure formation involved in morphogenesis |
| F | 0003779 | molecular_function | actin binding |
| F | 0003785 | molecular_function | actin monomer binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ANP A 401 |
| Chain | Residue |
| A | GLY13 |
| A | GLY182 |
| A | ARG210 |
| A | LYS213 |
| A | GLU214 |
| A | GLY302 |
| A | THR303 |
| A | MET305 |
| A | TYR306 |
| A | MG402 |
| C | TYR101 |
| A | SER14 |
| A | GLY15 |
| A | MET16 |
| A | LYS18 |
| A | GLY156 |
| A | ASP157 |
| A | GLY158 |
| A | VAL159 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ANP401 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ANP B 401 |
| Chain | Residue |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | MET16 |
| B | LYS18 |
| B | GLY156 |
| B | ASP157 |
| B | GLY158 |
| B | GLY182 |
| B | LYS213 |
| B | GLU214 |
| B | GLY301 |
| B | GLY302 |
| B | THR303 |
| B | MET305 |
| B | TYR306 |
| B | LYS336 |
| B | MG402 |
| B | HOH502 |
| B | HOH508 |
| B | HOH521 |
| C | ALA145 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | ANP401 |
| B | HOH502 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ANP D 401 |
| Chain | Residue |
| D | GLY13 |
| D | SER14 |
| D | GLY15 |
| D | MET16 |
| D | LYS18 |
| D | GLY156 |
| D | ASP157 |
| D | GLY158 |
| D | GLY182 |
| D | ARG210 |
| D | LYS213 |
| D | GLU214 |
| D | GLY302 |
| D | THR303 |
| D | MET305 |
| D | TYR306 |
| D | MG402 |
| D | HOH518 |
| D | HOH528 |
| F | TYR101 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 402 |
| Chain | Residue |
| D | ANP401 |
| D | HOH528 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ANP E 401 |
| Chain | Residue |
| E | GLY13 |
| E | SER14 |
| E | GLY15 |
| E | MET16 |
| E | LYS18 |
| E | GLY156 |
| E | ASP157 |
| E | GLY158 |
| E | GLY182 |
| E | LYS213 |
| E | GLU214 |
| E | GLY302 |
| E | THR303 |
| E | MET305 |
| E | TYR306 |
| E | LYS336 |
| E | MG402 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E 402 |
| Chain | Residue |
| E | ANP401 |
| E | HOH502 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| B | TYR53-GLY63 | |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WISKqEYDE |
| Chain | Residue | Details |
| B | TRP356-GLU364 | |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR |
| Chain | Residue | Details |
| B | LEU104-ARG116 | |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Methionine sulfoxide","evidences":[{"source":"PubMed","id":"22116028","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P02572","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Domain: {"description":"WH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00406","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Domain: {"description":"WH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00406","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 58 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
