4JFS

Crystal structure of a bacterial fucosidase with iminosugar inhibitor 4-epi-(+)-Codonopsinine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004560	molecular_function	alpha-L-fucosidase activity
A	0005764	cellular_component	lysosome
A	0005975	biological_process	carbohydrate metabolic process
A	0006004	biological_process	fucose metabolic process
A	0016139	biological_process	glycoside catabolic process
A	0016787	molecular_function	hydrolase activity
B	0004560	molecular_function	alpha-L-fucosidase activity
B	0005764	cellular_component	lysosome
B	0005975	biological_process	carbohydrate metabolic process
B	0006004	biological_process	fucose metabolic process
B	0016139	biological_process	glycoside catabolic process
B	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 16Z A 501

Chain	Residue
A	HIS66
A	TRP316
A	GOL506
A	GLU87
A	TRP88
A	HIS135
A	TYR178
A	ASP229
A	TRP232
A	ARG262
A	GLU288

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD A 502

Chain	Residue
A	ILE65
A	TRP117
A	MET120
A	TYR168
A	PHE359

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IMD A 503

Chain	Residue
A	LYS90
A	PRO96
A	ALA97
A	HOH864

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IMD A 504

Chain	Residue
A	ARG399

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	ARG262
A	ARG271
A	HIS272
A	HOH988

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 506

Chain	Residue
A	ALA85
A	GLU87
A	TRP88
A	TRP92
A	ASN314
A	16Z501
A	HOH713
A	HOH1076

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 16Z B 501

Chain	Residue
B	HIS66
B	GLU87
B	TRP88
B	HIS135
B	TYR178
B	ASP229
B	TRP232
B	ARG262
B	GLU288
B	TRP316

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD B 502

Chain	Residue
B	ILE65
B	TRP117
B	MET120
B	TYR168
B	PHE359

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IMD B 503

Chain	Residue
B	TRP241

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 504

Chain	Residue
B	ARG262
B	ARG271
B	HIS272
B	HOH856

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 505

Chain	Residue
B	LYS90
B	PRO96
B	ALA97
B	HOH904

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 506

Chain	Residue
B	GLY286
B	GLU288
B	ARG290
B	HOH974

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EPE B 507

Chain	Residue
B	TYR82
B	GLY83
B	GLY84
B	TRP92
B	HOH972

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