Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JEQ

Different Contribution of Conserved Amino Acids to the Global Properties of Homologous Enzymes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0020015	cellular_component	glycosome
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0020015	cellular_component	glycosome
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0020015	cellular_component	glycosome
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0020015	cellular_component	glycosome
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016853	molecular_function	isomerase activity
E	0019563	biological_process	glycerol catabolic process
E	0020015	cellular_component	glycosome
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
F	0004807	molecular_function	triose-phosphate isomerase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0016853	molecular_function	isomerase activity
F	0019563	biological_process	glycerol catabolic process
F	0020015	cellular_component	glycosome
F	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
G	0004807	molecular_function	triose-phosphate isomerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0016853	molecular_function	isomerase activity
G	0019563	biological_process	glycerol catabolic process
G	0020015	cellular_component	glycosome
G	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
H	0004807	molecular_function	triose-phosphate isomerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0016853	molecular_function	isomerase activity
H	0019563	biological_process	glycerol catabolic process
H	0020015	cellular_component	glycosome
H	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
I	0004807	molecular_function	triose-phosphate isomerase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006094	biological_process	gluconeogenesis
I	0006096	biological_process	glycolytic process
I	0016853	molecular_function	isomerase activity
I	0019563	biological_process	glycerol catabolic process
I	0020015	cellular_component	glycosome
I	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
J	0004807	molecular_function	triose-phosphate isomerase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006094	biological_process	gluconeogenesis
J	0006096	biological_process	glycolytic process
J	0016853	molecular_function	isomerase activity
J	0019563	biological_process	glycerol catabolic process
J	0020015	cellular_component	glycosome
J	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
K	0004807	molecular_function	triose-phosphate isomerase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006094	biological_process	gluconeogenesis
K	0006096	biological_process	glycolytic process
K	0016853	molecular_function	isomerase activity
K	0019563	biological_process	glycerol catabolic process
K	0020015	cellular_component	glycosome
K	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
L	0004807	molecular_function	triose-phosphate isomerase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006094	biological_process	gluconeogenesis
L	0006096	biological_process	glycolytic process
L	0016853	molecular_function	isomerase activity
L	0019563	biological_process	glycerol catabolic process
L	0020015	cellular_component	glycosome
L	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	SER213
A	GLY235
A	HOH422
A	HOH446
A	HOH505

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 302

Chain	Residue
A	SER20
A	LEU238

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG B 301

Chain	Residue
B	ALA49
B	LYS52
B	GLU53
B	PHE86
B	HOH436
A	MET50
A	HOH447

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG B 302

Chain	Residue
B	LYS3
B	TYR223
B	GLN224
B	GLN250
B	HOH413

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG C 301

Chain	Residue
C	ASN11
C	LYS13
C	HIS95
C	SER213
C	GLY235

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
I	TRP193

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	LYS13
D	ALA171
D	ILE172
D	GLY173
D	SER213
D	GLY234
D	GLY235
D	HOH415
D	HOH418
D	HOH475

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG E 301

Chain	Residue
E	SER192

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 301

Chain	Residue
H	LYS13
H	GLY212
H	GLY234
H	GLY235

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 K 301

Chain	Residue
K	LYS13
K	GLY234
K	GLY235

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG

Chain	Residue	Details
A	ALA165-GLY175

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Electrophile"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)