Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JD6

Crystal structure of Mycobacterium tuberculosis Eis in complex with coenzyme A and tobramycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0008080	molecular_function	N-acetyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030649	biological_process	aminoglycoside antibiotic catabolic process
A	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
A	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
A	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0043655	cellular_component	host extracellular space
A	0044161	cellular_component	host cell cytoplasmic vesicle
A	0046677	biological_process	response to antibiotic
A	0051701	biological_process	biological process involved in interaction with host
A	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
A	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
A	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
A	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
A	0097691	cellular_component	bacterial extracellular vesicle
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0008080	molecular_function	N-acetyltransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0030649	biological_process	aminoglycoside antibiotic catabolic process
B	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
B	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
B	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0043655	cellular_component	host extracellular space
B	0044161	cellular_component	host cell cytoplasmic vesicle
B	0046677	biological_process	response to antibiotic
B	0051701	biological_process	biological process involved in interaction with host
B	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
B	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
B	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
B	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
B	0097691	cellular_component	bacterial extracellular vesicle
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0008080	molecular_function	N-acetyltransferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0030649	biological_process	aminoglycoside antibiotic catabolic process
C	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
C	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
C	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0043655	cellular_component	host extracellular space
C	0044161	cellular_component	host cell cytoplasmic vesicle
C	0046677	biological_process	response to antibiotic
C	0051701	biological_process	biological process involved in interaction with host
C	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
C	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
C	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
C	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
C	0097691	cellular_component	bacterial extracellular vesicle
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0008080	molecular_function	N-acetyltransferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0030649	biological_process	aminoglycoside antibiotic catabolic process
D	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
D	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
D	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0043655	cellular_component	host extracellular space
D	0044161	cellular_component	host cell cytoplasmic vesicle
D	0046677	biological_process	response to antibiotic
D	0051701	biological_process	biological process involved in interaction with host
D	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
D	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
D	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
D	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
D	0097691	cellular_component	bacterial extracellular vesicle
E	0005576	cellular_component	extracellular region
E	0005829	cellular_component	cytosol
E	0008080	molecular_function	N-acetyltransferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0030649	biological_process	aminoglycoside antibiotic catabolic process
E	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
E	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
E	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
E	0042802	molecular_function	identical protein binding
E	0043655	cellular_component	host extracellular space
E	0044161	cellular_component	host cell cytoplasmic vesicle
E	0046677	biological_process	response to antibiotic
E	0051701	biological_process	biological process involved in interaction with host
E	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
E	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
E	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
E	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
E	0097691	cellular_component	bacterial extracellular vesicle
F	0005576	cellular_component	extracellular region
F	0005829	cellular_component	cytosol
F	0008080	molecular_function	N-acetyltransferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0030649	biological_process	aminoglycoside antibiotic catabolic process
F	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
F	0034054	biological_process	symbiont-mediated suppression of host defense-related programmed cell death
F	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
F	0042802	molecular_function	identical protein binding
F	0043655	cellular_component	host extracellular space
F	0044161	cellular_component	host cell cytoplasmic vesicle
F	0046677	biological_process	response to antibiotic
F	0051701	biological_process	biological process involved in interaction with host
F	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
F	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
F	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
F	0061733	molecular_function	peptide-lysine-N-acetyltransferase activity
F	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE COA A 500

Chain	Residue
A	PHE24
A	LEU97
A	ARG98
A	SER121
A	GLU122
A	ILE125
A	TYR126
A	ARG128
A	TOY501
B	ASP260
B	SER261
A	VAL85
A	VAL87
A	HIS91
A	ARG92
A	ARG93
A	ARG94
A	GLY95
A	LEU96

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TOY A 501

Chain	Residue
A	PHE24
A	ASP26
A	ILE28
A	TRP36
A	SER83
A	PHE84
A	VAL85
A	HIS119
A	TYR126
A	GLU203
A	GLU401
A	PHE402
A	COA500

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA B 500

Chain	Residue
B	PHE24
B	VAL85
B	VAL87
B	ARG92
B	ARG93
B	ARG94
B	GLY95
B	LEU96
B	LEU97
B	ARG98
B	SER121
B	GLU122
B	ILE125
B	TYR126
B	ARG128
B	TOY501
C	ASP260
C	SER261

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TOY B 501

Chain	Residue
B	PHE24
B	ASP26
B	ILE28
B	TRP36
B	SER83
B	PHE84
B	VAL85
B	HIS119
B	TYR126
B	GLU203
B	GLU401
B	PHE402
B	COA500

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA C 500

Chain	Residue
A	ASP260
A	SER261
C	VAL85
C	VAL87
C	ARG92
C	ARG93
C	ARG94
C	GLY95
C	LEU96
C	LEU97
C	ARG98
C	HIS119
C	SER121
C	GLU122
C	ILE125
C	TYR126
C	ARG128

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE COA D 500

Chain	Residue
D	VAL85
D	VAL87
D	ARG92
D	ARG93
D	GLY95
D	LEU96
D	LEU97
D	ARG98
D	SER121
D	GLU122
D	ILE125
D	TYR126
D	ARG128
F	ASP260
F	SER261

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA E 500

Chain	Residue
E	GLY95
E	LEU96
E	LEU97
E	ARG98
E	HIS119
E	SER121
E	GLU122
E	ILE125
E	TYR126
E	ARG128
D	ASP260
E	VAL85
E	VAL87
E	ARG93

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA F 500

Chain	Residue
E	ASP260
F	VAL85
F	VAL87
F	HIS91
F	ARG92
F	ARG93
F	ARG94
F	GLY95
F	LEU96
F	LEU97
F	ARG98
F	HIS119
F	SER121
F	GLU122
F	ILE125
F	TYR126
F	ARG128

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:21628583

Chain	Residue	Details
A	TYR126
B	TYR126
C	TYR126
D	TYR126
E	TYR126
F	TYR126

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton acceptor; via carboxylate => ECO:0000305\|PubMed:21628583

Chain	Residue	Details
A	PHE402
B	PHE402
C	PHE402
D	PHE402
E	PHE402
F	PHE402

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:22547814, ECO:0000305\|PubMed:21628583, ECO:0007744\|PDB:3RYO

Chain	Residue	Details
A	VAL85
E	SER121
F	VAL85
F	SER121
A	SER121
B	VAL85
B	SER121
C	VAL85
C	SER121
D	VAL85
D	SER121
E	VAL85

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:22547814, ECO:0000305\|PubMed:21628583, ECO:0000305\|PubMed:24106131, ECO:0000305\|PubMed:27010218, ECO:0007744\|PDB:3RYO

Chain	Residue	Details
A	ARG93
B	ARG93
C	ARG93
D	ARG93
E	ARG93
F	ARG93

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)