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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4JBW

Crystal structure of E. coli maltose transporter MalFGK2 in complex with its regulatory protein EIIAglc

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0008643biological_processcarbohydrate transport
A0015423molecular_functionABC-type maltose transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0022857molecular_functiontransmembrane transporter activity
A0034763biological_processnegative regulation of transmembrane transport
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0140297molecular_functionDNA-binding transcription factor binding
A0140359molecular_functionABC-type transporter activity
A1902344biological_processnegative regulation of maltose transport
A1904981biological_processmaltose transmembrane transport
A1990060cellular_componentmaltose transport complex
A1990154cellular_componentenzyme IIA-maltose transporter complex
B0000166molecular_functionnucleotide binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0008643biological_processcarbohydrate transport
B0015423molecular_functionABC-type maltose transporter activity
B0015768biological_processmaltose transport
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0022857molecular_functiontransmembrane transporter activity
B0034763biological_processnegative regulation of transmembrane transport
B0042956biological_processmaltodextrin transmembrane transport
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B0055085biological_processtransmembrane transport
B0140297molecular_functionDNA-binding transcription factor binding
B0140359molecular_functionABC-type transporter activity
B1902344biological_processnegative regulation of maltose transport
B1904981biological_processmaltose transmembrane transport
B1990060cellular_componentmaltose transport complex
B1990154cellular_componentenzyme IIA-maltose transporter complex
C0000166molecular_functionnucleotide binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0008643biological_processcarbohydrate transport
C0015423molecular_functionABC-type maltose transporter activity
C0015768biological_processmaltose transport
C0016020cellular_componentmembrane
C0016887molecular_functionATP hydrolysis activity
C0022857molecular_functiontransmembrane transporter activity
C0034763biological_processnegative regulation of transmembrane transport
C0042956biological_processmaltodextrin transmembrane transport
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C0055085biological_processtransmembrane transport
C0140297molecular_functionDNA-binding transcription factor binding
C0140359molecular_functionABC-type transporter activity
C1902344biological_processnegative regulation of maltose transport
C1904981biological_processmaltose transmembrane transport
C1990060cellular_componentmaltose transport complex
C1990154cellular_componentenzyme IIA-maltose transporter complex
D0000166molecular_functionnucleotide binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0008643biological_processcarbohydrate transport
D0015423molecular_functionABC-type maltose transporter activity
D0015768biological_processmaltose transport
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0022857molecular_functiontransmembrane transporter activity
D0034763biological_processnegative regulation of transmembrane transport
D0042956biological_processmaltodextrin transmembrane transport
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D0055085biological_processtransmembrane transport
D0140297molecular_functionDNA-binding transcription factor binding
D0140359molecular_functionABC-type transporter activity
D1902344biological_processnegative regulation of maltose transport
D1904981biological_processmaltose transmembrane transport
D1990060cellular_componentmaltose transport complex
D1990154cellular_componentenzyme IIA-maltose transporter complex
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0006974biological_processDNA damage response
F0015423molecular_functionABC-type maltose transporter activity
F0015768biological_processmaltose transport
F0016020cellular_componentmembrane
F0034763biological_processnegative regulation of transmembrane transport
F0042956biological_processmaltodextrin transmembrane transport
F0043190cellular_componentATP-binding cassette (ABC) transporter complex
F0055085biological_processtransmembrane transport
F1902344biological_processnegative regulation of maltose transport
F1904981biological_processmaltose transmembrane transport
F1990060cellular_componentmaltose transport complex
F1990154cellular_componentenzyme IIA-maltose transporter complex
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0015423molecular_functionABC-type maltose transporter activity
G0015768biological_processmaltose transport
G0016020cellular_componentmembrane
G0034763biological_processnegative regulation of transmembrane transport
G0042956biological_processmaltodextrin transmembrane transport
G0043190cellular_componentATP-binding cassette (ABC) transporter complex
G0055085biological_processtransmembrane transport
G1902344biological_processnegative regulation of maltose transport
G1904981biological_processmaltose transmembrane transport
G1990060cellular_componentmaltose transport complex
G1990154cellular_componentenzyme IIA-maltose transporter complex
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006974biological_processDNA damage response
H0015423molecular_functionABC-type maltose transporter activity
H0015768biological_processmaltose transport
H0016020cellular_componentmembrane
H0034763biological_processnegative regulation of transmembrane transport
H0042956biological_processmaltodextrin transmembrane transport
H0043190cellular_componentATP-binding cassette (ABC) transporter complex
H0055085biological_processtransmembrane transport
H1902344biological_processnegative regulation of maltose transport
H1904981biological_processmaltose transmembrane transport
H1990060cellular_componentmaltose transport complex
H1990154cellular_componentenzyme IIA-maltose transporter complex
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0015423molecular_functionABC-type maltose transporter activity
I0015768biological_processmaltose transport
I0016020cellular_componentmembrane
I0034763biological_processnegative regulation of transmembrane transport
I0042956biological_processmaltodextrin transmembrane transport
I0043190cellular_componentATP-binding cassette (ABC) transporter complex
I0055085biological_processtransmembrane transport
I1902344biological_processnegative regulation of maltose transport
I1904981biological_processmaltose transmembrane transport
I1990060cellular_componentmaltose transport complex
I1990154cellular_componentenzyme IIA-maltose transporter complex
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0009401biological_processphosphoenolpyruvate-dependent sugar phosphotransferase system
M0009898cellular_componentcytoplasmic side of plasma membrane
M0016020cellular_componentmembrane
M0016301molecular_functionkinase activity
M0016740molecular_functiontransferase activity
M0034763biological_processnegative regulation of transmembrane transport
M0043610biological_processregulation of carbohydrate utilization
M0045912biological_processnegative regulation of carbohydrate metabolic process
M0046872molecular_functionmetal ion binding
M1902344biological_processnegative regulation of maltose transport
M1902495cellular_componenttransmembrane transporter complex
M1990154cellular_componentenzyme IIA-maltose transporter complex
N0005515molecular_functionprotein binding
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0009401biological_processphosphoenolpyruvate-dependent sugar phosphotransferase system
N0009898cellular_componentcytoplasmic side of plasma membrane
N0016020cellular_componentmembrane
N0016301molecular_functionkinase activity
N0016740molecular_functiontransferase activity
N0034763biological_processnegative regulation of transmembrane transport
N0043610biological_processregulation of carbohydrate utilization
N0045912biological_processnegative regulation of carbohydrate metabolic process
N0046872molecular_functionmetal ion binding
N1902344biological_processnegative regulation of maltose transport
N1902495cellular_componenttransmembrane transporter complex
N1990154cellular_componentenzyme IIA-maltose transporter complex
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005829cellular_componentcytosol
O0009401biological_processphosphoenolpyruvate-dependent sugar phosphotransferase system
O0009898cellular_componentcytoplasmic side of plasma membrane
O0016020cellular_componentmembrane
O0016301molecular_functionkinase activity
O0016740molecular_functiontransferase activity
O0034763biological_processnegative regulation of transmembrane transport
O0043610biological_processregulation of carbohydrate utilization
O0045912biological_processnegative regulation of carbohydrate metabolic process
O0046872molecular_functionmetal ion binding
O1902344biological_processnegative regulation of maltose transport
O1902495cellular_componenttransmembrane transporter complex
O1990154cellular_componentenzyme IIA-maltose transporter complex
P0005515molecular_functionprotein binding
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0009401biological_processphosphoenolpyruvate-dependent sugar phosphotransferase system
P0009898cellular_componentcytoplasmic side of plasma membrane
P0016020cellular_componentmembrane
P0016301molecular_functionkinase activity
P0016740molecular_functiontransferase activity
P0034763biological_processnegative regulation of transmembrane transport
P0043610biological_processregulation of carbohydrate utilization
P0045912biological_processnegative regulation of carbohydrate metabolic process
P0046872molecular_functionmetal ion binding
P1902344biological_processnegative regulation of maltose transport
P1902495cellular_componenttransmembrane transporter complex
P1990154cellular_componentenzyme IIA-maltose transporter complex
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PGV F 4001
ChainResidue
FCYS304
FLEU305
FTRP308
FTYR400
FPRO410
FPHE414
GARG12
GTHR16
site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PGV H 601
ChainResidue
HCYS304
HLEU305
HTRP308
HTYR400
HPRO410
HASN413
IARG12
ITHR16
HVAL301
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRVAIGRTL
ChainResidueDetails
ALEU134-LEU148
site_idPS00371
Number of Residues13
DetailsPTS_EIIA_TYPE_1_HIS PTS EIIA domains phosphorylation site signature 1. GveLFVHFGIdTV
ChainResidueDetails
MGLY84-VAL96
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues468
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues533
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues204
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues840
DetailsDomain: {"description":"ABC transmembrane type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues920
DetailsDomain: {"description":"ABC transporter","evidences":[{"source":"HAMAP-Rule","id":"MF_01709","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01709","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues416
DetailsDomain: {"description":"PTS EIIA type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00416","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsActive site: {"description":"Tele-phosphohistidine intermediate; for EIIA activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00416","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6383826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1961703","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9405042","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8170944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9405042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1961703","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsSite: {"description":"Important for phospho-donor activity","evidences":[{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"Phosphohistidine; by HPr","evidences":[{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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