Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4JAX

Crystal structure of dimeric KlHxk1 in crystal form X

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001678	biological_process	intracellular glucose homeostasis
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	glucose binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006096	biological_process	glycolytic process
A	0008865	molecular_function	fructokinase activity
A	0016301	molecular_function	kinase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019158	molecular_function	mannokinase activity
A	0019318	biological_process	hexose metabolic process
A	0019637	biological_process	organophosphate metabolic process
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0001678	biological_process	intracellular glucose homeostasis
B	0004340	molecular_function	glucokinase activity
B	0004396	molecular_function	hexokinase activity
B	0005524	molecular_function	ATP binding
B	0005536	molecular_function	glucose binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006013	biological_process	mannose metabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
B	0006096	biological_process	glycolytic process
B	0008865	molecular_function	fructokinase activity
B	0016301	molecular_function	kinase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019158	molecular_function	mannokinase activity
B	0019318	biological_process	hexose metabolic process
B	0019637	biological_process	organophosphate metabolic process
B	0046835	biological_process	carbohydrate phosphorylation
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0001678	biological_process	intracellular glucose homeostasis
C	0004340	molecular_function	glucokinase activity
C	0004396	molecular_function	hexokinase activity
C	0005524	molecular_function	ATP binding
C	0005536	molecular_function	glucose binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006006	biological_process	glucose metabolic process
C	0006013	biological_process	mannose metabolic process
C	0006091	biological_process	generation of precursor metabolites and energy
C	0006096	biological_process	glycolytic process
C	0008865	molecular_function	fructokinase activity
C	0016301	molecular_function	kinase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019158	molecular_function	mannokinase activity
C	0019318	biological_process	hexose metabolic process
C	0019637	biological_process	organophosphate metabolic process
C	0046835	biological_process	carbohydrate phosphorylation
C	0051156	biological_process	glucose 6-phosphate metabolic process
C	1901135	biological_process	carbohydrate derivative metabolic process
D	0001678	biological_process	intracellular glucose homeostasis
D	0004340	molecular_function	glucokinase activity
D	0004396	molecular_function	hexokinase activity
D	0005524	molecular_function	ATP binding
D	0005536	molecular_function	glucose binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006006	biological_process	glucose metabolic process
D	0006013	biological_process	mannose metabolic process
D	0006091	biological_process	generation of precursor metabolites and energy
D	0006096	biological_process	glycolytic process
D	0008865	molecular_function	fructokinase activity
D	0016301	molecular_function	kinase activity
D	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
D	0019158	molecular_function	mannokinase activity
D	0019318	biological_process	hexose metabolic process
D	0019637	biological_process	organophosphate metabolic process
D	0046835	biological_process	carbohydrate phosphorylation
D	0051156	biological_process	glucose 6-phosphate metabolic process
D	1901135	biological_process	carbohydrate derivative metabolic process
E	0001678	biological_process	intracellular glucose homeostasis
E	0004340	molecular_function	glucokinase activity
E	0004396	molecular_function	hexokinase activity
E	0005524	molecular_function	ATP binding
E	0005536	molecular_function	glucose binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0006006	biological_process	glucose metabolic process
E	0006013	biological_process	mannose metabolic process
E	0006091	biological_process	generation of precursor metabolites and energy
E	0006096	biological_process	glycolytic process
E	0008865	molecular_function	fructokinase activity
E	0016301	molecular_function	kinase activity
E	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
E	0019158	molecular_function	mannokinase activity
E	0019318	biological_process	hexose metabolic process
E	0019637	biological_process	organophosphate metabolic process
E	0046835	biological_process	carbohydrate phosphorylation
E	0051156	biological_process	glucose 6-phosphate metabolic process
E	1901135	biological_process	carbohydrate derivative metabolic process
F	0001678	biological_process	intracellular glucose homeostasis
F	0004340	molecular_function	glucokinase activity
F	0004396	molecular_function	hexokinase activity
F	0005524	molecular_function	ATP binding
F	0005536	molecular_function	glucose binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0006006	biological_process	glucose metabolic process
F	0006013	biological_process	mannose metabolic process
F	0006091	biological_process	generation of precursor metabolites and energy
F	0006096	biological_process	glycolytic process
F	0008865	molecular_function	fructokinase activity
F	0016301	molecular_function	kinase activity
F	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
F	0019158	molecular_function	mannokinase activity
F	0019318	biological_process	hexose metabolic process
F	0019637	biological_process	organophosphate metabolic process
F	0046835	biological_process	carbohydrate phosphorylation
F	0051156	biological_process	glucose 6-phosphate metabolic process
F	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	HIS185

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 502

Chain	Residue
A	SER37
A	SER38
A	HOH684

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 503

Chain	Residue
A	GLY232
A	THR233
A	GLY417
A	SER418

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 A 504

Chain	Residue
A	LYS111
A	ASN91

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	SER157
A	ASN209
A	ASP210
A	THR211
A	ILE230
A	GLY234
A	ASN236

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 506

Chain	Residue
A	TYR73
A	LEU219
A	PRO223
A	GLN224
A	THR225
A	LYS226
A	TYR408
A	HOH616

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 501

Chain	Residue
B	GLY232
B	THR233
B	GLY417
B	SER418

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 502

Chain	Residue
B	SER157
B	ASN209
B	ASP210
B	THR211
B	ILE230
B	GLY234
B	ASN236

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 C 501

Chain	Residue
C	HIS185

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 502

Chain	Residue
C	GLY88
C	GLY89
C	THR90
C	PO4504

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 C 503

Chain	Residue
C	THR233
C	SER418

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 504

Chain	Residue
C	ASN91
C	LYS111
C	PO4502

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 505

Chain	Residue
C	ASN209
C	ASP210
C	THR211
C	GLY234
C	VAL235
C	ASN236

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 506

Chain	Residue
C	LYS409
C	TRP440
C	HOH602

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 D 501

Chain	Residue
D	ASN91
D	LYS111

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 D 502

Chain	Residue
D	GLY232
D	THR233
D	GLY417
D	SER418

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 D 503

Chain	Residue
D	GLY181
D	HIS185

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PO4 D 504

Chain	Residue
D	HIS185

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 505

Chain	Residue
D	LYS328
E	TYR112
E	GLU136
E	HOH602
F	ASN356

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 501

Chain	Residue
E	GLY232
E	THR233
E	GLY417
E	SER418

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 E 502

Chain	Residue
E	SER37
E	SER38

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 E 503

Chain	Residue
E	ASN91
E	LYS111
E	GOL505

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 504

Chain	Residue
E	ASN209
E	ASP210
E	THR211
E	GLY234
E	ASN236

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 505

Chain	Residue
E	GLY88
E	GLY89
E	THR90
E	PO4503
E	HOH628

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 F 501

Chain	Residue
F	GLY232
F	THR233
F	SER418

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPasqkkINsgvLqrWTKgF

Chain	Residue	Details
A	LEU152-PHE177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS111
B	LYS111
C	LYS111
D	LYS111
E	LYS111
F	LYS111

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:12882981

Chain	Residue	Details
A	SEP15
B	SEP15
C	SEP15
D	SEP15
E	SEP15
F	SEP15

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)