4JAV

Structural basis of a rationally rewired protein-protein interface (HK853wt and RR468mutant V13P, L14I, I17M and N21V)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0007165	biological_process	signal transduction
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0007165	biological_process	signal transduction
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0000160	biological_process	phosphorelay signal transduction system
C	0005515	molecular_function	protein binding
C	0046872	molecular_function	metal ion binding
D	0000160	biological_process	phosphorelay signal transduction system
D	0005515	molecular_function	protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	LYS239
A	ARG243
A	ARG246
A	ARG423
A	TYR429

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	HOH608
A	ASN379
A	LYS383
A	MG503
A	ADP504

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 503

Chain	Residue
A	ASN379
A	ASN380
A	LYS383
A	SO4502
A	ADP504
A	HOH608

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ADP A 504

Chain	Residue
A	ASN380
A	LYS383
A	TYR384
A	ASP411
A	ILE416
A	ILE424
A	TYR429
A	ARG430
A	VAL431
A	GLY441
A	THR442
A	GLY443
A	GLY445
A	LEU446
A	SER470
A	PHE472
A	SO4502
A	MG503
A	HOH608

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
A	HIS260
B	ARG314
B	ARG317
B	SER319

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
A	ARG314
A	ARG317
B	HIS260
B	LYS386
B	LYS387
B	ASP388

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 503

Chain	Residue
B	ASN379
B	LYS383
B	PRO440
B	GLY441
B	THR442
B	ADP505

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 504

Chain	Residue
B	ASN380
B	LYS383
B	ADP505

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ADP B 505

Chain	Residue
B	ASN380
B	LYS383
B	TYR384
B	ASP411
B	ILE414
B	ILE416
B	ILE424
B	TYR429
B	ARG430
B	VAL431
B	GLY441
B	GLY443
B	GLY445
B	LEU446
B	SER470
B	PHE472
B	SO4503
B	MG504

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 506

Chain	Residue
B	ARG314

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site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 201

Chain	Residue
C	ASP10
C	BFD53
C	MET55
C	HOH304

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site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 201

Chain	Residue
D	ASP10
D	BFD53
D	MET55

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