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4JAL

Crystal structure of tRNA (Um34/Cm34) methyltransferase TrmL from Escherichia coli with SAH

Functional Information from GO Data
ChainGOidnamespacecontents
A0001510biological_processRNA methylation
A0002131biological_processwobble position cytosine ribose methylation
A0002132biological_processwobble position uridine ribose methylation
A0003723molecular_functionRNA binding
A0005737cellular_componentcytoplasm
A0006396biological_processRNA processing
A0008033biological_processtRNA processing
A0008168molecular_functionmethyltransferase activity
A0008173molecular_functionRNA methyltransferase activity
A0008175molecular_functiontRNA methyltransferase activity
A0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
A0030488biological_processtRNA methylation
A0032259biological_processmethylation
A0042803molecular_functionprotein homodimerization activity
A0141098molecular_functiontRNA (cytidine(34)-2'-O)-methyltransferase activity
A0141102molecular_functiontRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity
B0001510biological_processRNA methylation
B0002131biological_processwobble position cytosine ribose methylation
B0002132biological_processwobble position uridine ribose methylation
B0003723molecular_functionRNA binding
B0005737cellular_componentcytoplasm
B0006396biological_processRNA processing
B0008033biological_processtRNA processing
B0008168molecular_functionmethyltransferase activity
B0008173molecular_functionRNA methyltransferase activity
B0008175molecular_functiontRNA methyltransferase activity
B0008757molecular_functionS-adenosylmethionine-dependent methyltransferase activity
B0030488biological_processtRNA methylation
B0032259biological_processmethylation
B0042803molecular_functionprotein homodimerization activity
B0141098molecular_functiontRNA (cytidine(34)-2'-O)-methyltransferase activity
B0141102molecular_functiontRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE SAH A 201
ChainResidue
AASN14
AILE122
AMET124
ASER130
AMET131
AASN132
ALEU133
AEPE202
AHOH303
ALEU78
ATHR79
APHE99
AGLY100
APRO101
AGLU102
AGLY105
AILE120

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EPE A 202
ChainResidue
ATHR79
ATHR80
ALYS81
ATHR103
AGLY105
ALEU106
ASAH201

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 201
ChainResidue
AASN17
AARG20
ALEU21
BMET131
BASN132
BASN135
BHOH310

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 202
ChainResidue
BLEU78
BTHR79
BTHR80
BLEU106
BSAH203

site_idAC5
Number of Residues15
DetailsBINDING SITE FOR RESIDUE SAH B 203
ChainResidue
AALA116
AGLU117
BLEU78
BTHR79
BPHE99
BGLY100
BPRO101
BGLU102
BGLY105
BILE120
BILE122
BMET124
BSER130
BMET131
BEDO202

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01885
ChainResidueDetails
ALEU78
AGLY100
AILE122
ASER130
BLEU78
BGLY100
BILE122
BSER130

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PDB entries from 2024-10-30

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