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4J37

Crystal structure of the catalytic domain of human Pus1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001522biological_processpseudouridine synthesis
A0003723molecular_functionRNA binding
A0009451biological_processRNA modification
A0009982molecular_functionpseudouridine synthase activity
A0031119biological_processtRNA pseudouridine synthesis
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 501
ChainResidue
AALA143
AARG144
AARG199

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 502
ChainResidue
ALYS85
ASER138
AARG223

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 503
ChainResidue
AASP146
AHOH761
AHOH779

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 504
ChainResidue
AASP146
AHIS292
AARG295
ALYS327
AHOH734
AHOH755

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:24722331, ECO:0007744|PDB:4ITS, ECO:0007744|PDB:4NZ6
ChainResidueDetails
AASP146

226707

PDB entries from 2024-10-30

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