4J1T
Crystal structure of Thermus thermophilus transhydrogenase heterotrimeric complex of the Alpha1 subunit dimer with the NADP binding domain (domain III) of the Beta subunit in P2(1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006740 | biological_process | NADPH regeneration |
| A | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006740 | biological_process | NADPH regeneration |
| B | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006740 | biological_process | NADPH regeneration |
| D | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 1902600 | biological_process | proton transmembrane transport |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006740 | biological_process | NADPH regeneration |
| E | 0008750 | molecular_function | proton-translocating NAD(P)+ transhydrogenase activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0050661 | molecular_function | NADP binding |
| E | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 401 |
| Chain | Residue |
| A | HIS146 |
| A | ARG149 |
| A | LEU150 |
| A | VAL300 |
| A | HOH529 |
| B | ARG149 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NAD B 500 |
| Chain | Residue |
| B | GLY176 |
| B | VAL177 |
| B | TYR196 |
| B | ASP197 |
| B | ARG199 |
| B | THR255 |
| B | ALA256 |
| B | GLN257 |
| B | LEU266 |
| B | HOH629 |
| B | ARG122 |
| B | GLY174 |
| B | VAL175 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAP C 500 |
| Chain | Residue |
| A | GLN127 |
| C | GLY300 |
| C | TYR301 |
| C | GLY302 |
| C | SER306 |
| C | VAL333 |
| C | ALA334 |
| C | GLY335 |
| C | ARG336 |
| C | MET337 |
| C | PRO338 |
| C | GLY375 |
| C | ALA376 |
| C | ASN377 |
| C | ASP378 |
| C | VAL379 |
| C | LYS409 |
| C | ARG410 |
| C | GLY411 |
| C | GLN412 |
| C | GLY413 |
| C | GLY415 |
| C | PHE416 |
| C | ASP435 |
| C | ALA436 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 401 |
| Chain | Residue |
| D | ARG188 |
| E | ARG188 |
| F | VAL343 |
| F | ALA346 |
| F | GLU347 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 402 |
| Chain | Residue |
| A | GLY373 |
| D | LYS110 |
| D | LYS111 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 403 |
| Chain | Residue |
| D | LEU85 |
| D | GLU86 |
| D | GLY88 |
| D | ALA89 |
| D | LYS110 |
| D | LYS111 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NAD E 500 |
| Chain | Residue |
| E | ARG122 |
| E | GLY174 |
| E | VAL175 |
| E | GLY176 |
| E | VAL177 |
| E | ASP197 |
| E | ARG199 |
| E | GLN205 |
| E | THR255 |
| E | ALA256 |
| E | LEU266 |
| E | HOH632 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP F 500 |
| Chain | Residue |
| D | GLN127 |
| F | GLY300 |
| F | TYR301 |
| F | GLY302 |
| F | LEU305 |
| F | SER306 |
| F | VAL333 |
| F | ALA334 |
| F | GLY335 |
| F | ARG336 |
| F | MET337 |
| F | PRO338 |
| F | GLY375 |
| F | ALA376 |
| F | ASN377 |
| F | ASP378 |
| F | VAL379 |
| F | LYS409 |
| F | ARG410 |
| F | GLY411 |
| F | GLN412 |
| F | GLY413 |
| F | GLY415 |
| F | PHE416 |
| F | GLY434 |
| F | ASP435 |
| F | ALA436 |
Functional Information from PROSITE/UniProt
| site_id | PS00837 |
| Number of Residues | 26 |
| Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VMGVGvAGlmAiatAkRLGAqVfayD |
| Chain | Residue | Details |
| A | VAL172-ASP197 |
