4J15
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004046 | molecular_function | aminoacylase activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004815 | molecular_function | aspartate-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006422 | biological_process | aspartyl-tRNA aminoacylation |
| A | 0016020 | cellular_component | membrane |
| A | 0016874 | molecular_function | ligase activity |
| A | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| A | 0045202 | cellular_component | synapse |
| A | 0065003 | biological_process | protein-containing complex assembly |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004046 | molecular_function | aminoacylase activity |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004815 | molecular_function | aspartate-tRNA ligase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006422 | biological_process | aspartyl-tRNA aminoacylation |
| B | 0016020 | cellular_component | membrane |
| B | 0016874 | molecular_function | ligase activity |
| B | 0017101 | cellular_component | aminoacyl-tRNA synthetase multienzyme complex |
| B | 0045202 | cellular_component | synapse |
| B | 0065003 | biological_process | protein-containing complex assembly |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | ARG63 |
| A | ALA64 |
| A | GLN82 |
| A | HOH783 |
| A | HOH876 |
| B | ASP261 |
| B | GOL602 |
| B | HOH819 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | VAL144 |
| A | ILE145 |
| A | SER146 |
| A | LEU147 |
| B | ASP434 |
| B | HOH852 |
| A | SER32 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | GLN199 |
| A | GLU474 |
| A | SER490 |
| A | MET491 |
| A | PHE492 |
| B | GLN219 |
| B | PRO221 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 604 |
| Chain | Residue |
| A | LYS40 |
| A | GOL605 |
| B | HIS300 |
| B | ARG345 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 605 |
| Chain | Residue |
| A | GLN38 |
| A | GOL604 |
| A | HOH843 |
| B | ARG408 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 601 |
| Chain | Residue |
| A | HIS204 |
| A | ARG207 |
| A | GLU208 |
| A | ILE211 |
| A | HOH768 |
| B | HIS204 |
| B | ARG207 |
| B | HOH799 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 602 |
| Chain | Residue |
| A | ARG63 |
| A | GLN82 |
| A | GOL601 |
| B | PHE295 |
| B | ASN296 |
| B | HOH841 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 603 |
| Chain | Residue |
| A | TYR297 |
| B | ARG43 |
| B | ASP115 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU229 | |
| B | ARG281 | |
| B | GLU424 | |
| B | SER427 | |
| B | ARG431 | |
| B | GLY472 | |
| A | ARG273 | |
| A | ARG281 | |
| A | GLU424 | |
| A | SER427 | |
| A | ARG431 | |
| A | GLY472 | |
| B | GLU229 | |
| B | ARG273 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR52 | |
| B | THR52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS74 | |
| A | LYS374 | |
| B | LYS74 | |
| B | LYS374 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER249 | |
| B | SER249 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKA => ECO:0000255 |
| Chain | Residue | Details |
| A | THR500 | |
| B | THR500 |
