4J0U

Crystal structure of IFIT5/ISG58

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000339	molecular_function	RNA cap binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003723	molecular_function	RNA binding
A	0003727	molecular_function	single-stranded RNA binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008266	molecular_function	poly(U) RNA binding
A	0008385	cellular_component	IkappaB kinase complex
A	0015629	cellular_component	actin cytoskeleton
A	0032587	cellular_component	ruffle membrane
A	0042995	cellular_component	cell projection
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045177	cellular_component	apical part of cell
A	0051607	biological_process	defense response to virus
A	0051707	biological_process	response to other organism

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Interaction with PPP-RNA

Chain	Residue	Details
A	GLU33
A	THR37
A	GLN41
A	LYS150
A	ARG186
A	TYR250

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with the 5'-triphosphate group of PPP-RNA

Chain	Residue	Details
A	GLN288

---